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Nationwide epidemiological survey of early chronic pancreatitis in Japan.
J Gastroenterol 2017; 52(8):992-1000JG

Abstract

BACKGROUND

The world's first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan.

METHODS

Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire.

RESULTS

The estimated number of early CP patients was 5410 (95% confidence interval 3675-6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95% confidence interval 1058-1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7%) and alcoholic (45.0%) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients.

CONCLUSIONS

We clarified the current status of early CP in Japan.

Authors+Show Affiliations

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. amasamune@med.tohoku.ac.jp.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Department of Gastroenterology, Toyohashi Municipal Hospital, Toyohashi, Japan.Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizu-Wakamatsu, Japan.Department of Gastroenterology, Gifu Municipal Hospital, Toyohashi, Japan.Department of Gastroenterology, JA Onomichi General Hospital, Onomichi, Japan.Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.Department of Medicine, Shiga University of Medical Science, Otsu, Japan.Shirane Gastrointestinal Clinic, Sendai, Japan.Department of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28130705

Citation

Masamune, Atsushi, et al. "Nationwide Epidemiological Survey of Early Chronic Pancreatitis in Japan." Journal of Gastroenterology, vol. 52, no. 8, 2017, pp. 992-1000.
Masamune A, Kikuta K, Nabeshima T, et al. Nationwide epidemiological survey of early chronic pancreatitis in Japan. J Gastroenterol. 2017;52(8):992-1000.
Masamune, A., Kikuta, K., Nabeshima, T., Nakano, E., Hirota, M., Kanno, A., ... Shimosegawa, T. (2017). Nationwide epidemiological survey of early chronic pancreatitis in Japan. Journal of Gastroenterology, 52(8), pp. 992-1000. doi:10.1007/s00535-017-1311-8.
Masamune A, et al. Nationwide Epidemiological Survey of Early Chronic Pancreatitis in Japan. J Gastroenterol. 2017;52(8):992-1000. PubMed PMID: 28130705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nationwide epidemiological survey of early chronic pancreatitis in Japan. AU - Masamune,Atsushi, AU - Kikuta,Kazuhiro, AU - Nabeshima,Tatsuhide, AU - Nakano,Eriko, AU - Hirota,Morihisa, AU - Kanno,Atsushi, AU - Kume,Kiyoshi, AU - Hamada,Shin, AU - Ito,Tetsuhide, AU - Fujita,Motokazu, AU - Irisawa,Atsushi, AU - Nakashima,Masanori, AU - Hanada,Keiji, AU - Eguchi,Takaaki, AU - Kato,Ryusuke, AU - Inatomi,Osamu, AU - Shirane,Akio, AU - Takeyama,Yoshifumi, AU - Tsuji,Ichiro, AU - Shimosegawa,Tooru, AU - ,, Y1 - 2017/01/27/ PY - 2016/11/29/received PY - 2017/01/12/accepted PY - 2017/1/29/pubmed PY - 2018/5/19/medline PY - 2017/1/29/entrez KW - Alcohol KW - Diagnosis KW - Endoscopic ultrasonography KW - Epidemiology KW - Functional dyspepsia SP - 992 EP - 1000 JF - Journal of gastroenterology JO - J. Gastroenterol. VL - 52 IS - 8 N2 - BACKGROUND: The world's first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan. METHODS: Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire. RESULTS: The estimated number of early CP patients was 5410 (95% confidence interval 3675-6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95% confidence interval 1058-1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7%) and alcoholic (45.0%) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients. CONCLUSIONS: We clarified the current status of early CP in Japan. SN - 1435-5922 UR - https://www.unboundmedicine.com/medline/citation/28130705/Nationwide_epidemiological_survey_of_early_chronic_pancreatitis_in_Japan_ L2 - https://dx.doi.org/10.1007/s00535-017-1311-8 DB - PRIME DP - Unbound Medicine ER -