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Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions.
Int J Pharm. 2017 Mar 15; 519(1-2):365-372.IJ

Abstract

A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40°C/75% RH. A number of solid state analytical techniques including PXRD, DSC, small angle X-ray scattering, FTIR and solid state NMR were used to characterise the physicochemical properties of the ASDs following processing and storage and to assess any interactions between components. Microtrac laser scattering analysis revealed a relationship between polymer levels and particle size distribution (PSD). Dissolution studies indicated that higher Soluplus content in the formulation resulted in higher concentrations of ITZ in acidic media.

Authors+Show Affiliations

Synthesis and Solid State Pharmaceutical Centre (SSPC), The BernalInstitute, University of Limerick, Ireland. Electronic address: mark.davis@ul.ie.Synthesis and Solid State Pharmaceutical Centre (SSPC), The BernalInstitute, University of Limerick, Ireland.School of Pharmacy, Cavanagh Pharmacy Building, NUI, Cork, Ireland.Synthesis and Solid State Pharmaceutical Centre (SSPC), The BernalInstitute, University of Limerick, Ireland.Synthesis and Solid State Pharmaceutical Centre (SSPC), The BernalInstitute, University of Limerick, Ireland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28131850

Citation

Davis, Mark T., et al. "Design of Spray Dried Ternary Solid Dispersions Comprising Itraconazole, Soluplus and HPMCP: Effect of Constituent Compositions." International Journal of Pharmaceutics, vol. 519, no. 1-2, 2017, pp. 365-372.
Davis MT, Potter CB, Mohammadpour M, et al. Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions. Int J Pharm. 2017;519(1-2):365-372.
Davis, M. T., Potter, C. B., Mohammadpour, M., Albadarin, A. B., & Walker, G. M. (2017). Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions. International Journal of Pharmaceutics, 519(1-2), 365-372. https://doi.org/10.1016/j.ijpharm.2017.01.043
Davis MT, et al. Design of Spray Dried Ternary Solid Dispersions Comprising Itraconazole, Soluplus and HPMCP: Effect of Constituent Compositions. Int J Pharm. 2017 Mar 15;519(1-2):365-372. PubMed PMID: 28131850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions. AU - Davis,Mark T, AU - Potter,Catherine B, AU - Mohammadpour,Maryam, AU - Albadarin,Ahmad B, AU - Walker,Gavin M, Y1 - 2017/01/25/ PY - 2016/10/27/received PY - 2017/01/19/revised PY - 2017/01/21/accepted PY - 2017/1/31/pubmed PY - 2017/6/18/medline PY - 2017/1/30/entrez KW - Amorphous KW - HPMCP KW - Itraconazole KW - Soluplus KW - Spray drying KW - Ternary SP - 365 EP - 372 JF - International journal of pharmaceutics JO - Int J Pharm VL - 519 IS - 1-2 N2 - A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40°C/75% RH. A number of solid state analytical techniques including PXRD, DSC, small angle X-ray scattering, FTIR and solid state NMR were used to characterise the physicochemical properties of the ASDs following processing and storage and to assess any interactions between components. Microtrac laser scattering analysis revealed a relationship between polymer levels and particle size distribution (PSD). Dissolution studies indicated that higher Soluplus content in the formulation resulted in higher concentrations of ITZ in acidic media. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/28131850/Design_of_spray_dried_ternary_solid_dispersions_comprising_itraconazole_soluplus_and_HPMCP:_Effect_of_constituent_compositions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(17)30052-2 DB - PRIME DP - Unbound Medicine ER -