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Comparison of voiding cystourethrography and urosonography with second-generation contrast agents in simultaneous prospective study.
J Ultrason. 2016 Dec; 16(67):339-347.JU

Abstract

BACKGROUND

The invasiveness and exposure to radiation in voiding cystourethrography led to the introduction of alternative methods of diagnosis of vesicoureteral reflux, including contrast enhanced voiding urosonography. While there is a limited number of studies comparing these methods using new generation ultrasound contrast agents, none of them compared both methods simultaneously. This study is aimed at assessing agreement between contrast enhanced voiding urosonography with second-generation ultrasound contrast agents and voiding cystourethrography.

METHODS

From April 2013 to May 2014, 83 children (37 female and 46 male), mean age 3.5 years, age range from 1 month to 17.5 years, underwent prospective simultaneous assessment by contrast enhanced voiding urosonography and voiding cystourethrography, with a total of 166 uretero-renal units evaluated.

RESULTS

The sensitivity of voiding cystourethrography and contrast enhanced voiding urosonography were comparable, amounting to 88%, however, neither reached 100% for the entire studied population. The negative predictive value of voiding urosonography and voiding cystourethrography was 97%, and there was no difference between both methods.

CONCLUSION

Voiding cystourethrography and contrast enhanced voiding urosonography are comparable methods in diagnosis of vesicoureteral reflux, and can be performed alternatively. However, some limitations of contrast enhanced voiding urosonography must be remembered.

Authors+Show Affiliations

Department of Radiology, Medical University of Gdańsk, Poland; M. Piskunowicz and D. Świętoń contributed equally to this work and are considered co-first authors.Department of Radiology, Medical University of Gdańsk, Poland; M. Piskunowicz and D. Świętoń contributed equally to this work and are considered co-first authors.Department of Radiology, Medical University of Gdańsk, Poland.Department of Paediatrics, Nephrology and Hypertension, Medical University of Gdańsk, Poland.Department of Radiology, Medical University of Gdańsk, Poland.Institute of Statistics, Department of Economic Sciences, Faculty of Management and Economics, Gdańsk University of Technology, Poland.Department of Radiology, Medical University of Gdańsk, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28138405

Citation

Piskunowicz, Maciej, et al. "Comparison of Voiding Cystourethrography and Urosonography With Second-generation Contrast Agents in Simultaneous Prospective Study." Journal of Ultrasonography, vol. 16, no. 67, 2016, pp. 339-347.
Piskunowicz M, Świętoń D, Rybczyńska D, et al. Comparison of voiding cystourethrography and urosonography with second-generation contrast agents in simultaneous prospective study. J Ultrason. 2016;16(67):339-347.
Piskunowicz, M., Świętoń, D., Rybczyńska, D., Czarniak, P., Szarmach, A., Kaszubowski, M., & Szurowska, E. (2016). Comparison of voiding cystourethrography and urosonography with second-generation contrast agents in simultaneous prospective study. Journal of Ultrasonography, 16(67), 339-347. https://doi.org/10.15557/JoU.2016.0034
Piskunowicz M, et al. Comparison of Voiding Cystourethrography and Urosonography With Second-generation Contrast Agents in Simultaneous Prospective Study. J Ultrason. 2016;16(67):339-347. PubMed PMID: 28138405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of voiding cystourethrography and urosonography with second-generation contrast agents in simultaneous prospective study. AU - Piskunowicz,Maciej, AU - Świętoń,Dominik, AU - Rybczyńska,Dorota, AU - Czarniak,Piotr, AU - Szarmach,Arkadiusz, AU - Kaszubowski,Mariusz, AU - Szurowska,Edyta, Y1 - 2016/12/30/ PY - 2016/10/04/received PY - 2016/10/15/revised PY - 2016/10/18/accepted PY - 2017/2/1/entrez PY - 2017/2/1/pubmed PY - 2017/2/1/medline KW - SonoVue KW - ultrasound contrast agent KW - vesicoureteral reflux KW - voiding cystourethrography KW - voiding urosonography SP - 339 EP - 347 JF - Journal of ultrasonography JO - J Ultrason VL - 16 IS - 67 N2 - BACKGROUND: The invasiveness and exposure to radiation in voiding cystourethrography led to the introduction of alternative methods of diagnosis of vesicoureteral reflux, including contrast enhanced voiding urosonography. While there is a limited number of studies comparing these methods using new generation ultrasound contrast agents, none of them compared both methods simultaneously. This study is aimed at assessing agreement between contrast enhanced voiding urosonography with second-generation ultrasound contrast agents and voiding cystourethrography. METHODS: From April 2013 to May 2014, 83 children (37 female and 46 male), mean age 3.5 years, age range from 1 month to 17.5 years, underwent prospective simultaneous assessment by contrast enhanced voiding urosonography and voiding cystourethrography, with a total of 166 uretero-renal units evaluated. RESULTS: The sensitivity of voiding cystourethrography and contrast enhanced voiding urosonography were comparable, amounting to 88%, however, neither reached 100% for the entire studied population. The negative predictive value of voiding urosonography and voiding cystourethrography was 97%, and there was no difference between both methods. CONCLUSION: Voiding cystourethrography and contrast enhanced voiding urosonography are comparable methods in diagnosis of vesicoureteral reflux, and can be performed alternatively. However, some limitations of contrast enhanced voiding urosonography must be remembered. SN - 2084-8404 UR - https://www.unboundmedicine.com/medline/citation/28138405/Comparison_of_voiding_cystourethrography_and_urosonography_with_second_generation_contrast_agents_in_simultaneous_prospective_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28138405/ DB - PRIME DP - Unbound Medicine ER -