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Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach.
Pathol Oncol Res. 2018 Jan; 24(1):19-29.PO

Abstract

The aim of the present study is to focus the chemopreventive potential of Emodin during 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Tumors were developed in the buccal pouches of golden Syrian hamsters by painting with 0.5% DMBA thrice a week for 14 weeks. The status of lipid peroxidation, antioxidants and detoxification agents were utilized as biochemical endpoints and the expression pattern of apoptotic proteins was employed as molecular endpoints in addition to the histopathological studies, to substantiate the anticancer potential of Emodin. Hamsters treated with DMBA + Emodin revealed mild to moderate precancerous lesions such as hyperplasia and dysplasia whereas 100% tumor formation was noticed in hamsters treated with DMBA alone. Also, Emodin treatment modulated the status of lipid peroxidation, antioxidants, phase I and II detoxification agents and apoptotic proteins in favor of the inhibition/reversal/suppression of the oral tumorigenesis in DMBA treated hamsters. The present study thus concludes that the chemopreventive potential of Emodin relies on its pro-apoptotic and antioxidant efficacy during DMBA induced hamster buccal pouch carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608002, India.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608002, India. sakshiman@rediffmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28138922

Citation

Manimaran, Asokan, and Shanmugam Manoharan. "Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach." Pathology Oncology Research : POR, vol. 24, no. 1, 2018, pp. 19-29.
Manimaran A, Manoharan S. Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach. Pathol Oncol Res. 2018;24(1):19-29.
Manimaran, A., & Manoharan, S. (2018). Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach. Pathology Oncology Research : POR, 24(1), 19-29. https://doi.org/10.1007/s12253-017-0205-7
Manimaran A, Manoharan S. Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach. Pathol Oncol Res. 2018;24(1):19-29. PubMed PMID: 28138922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach. AU - Manimaran,Asokan, AU - Manoharan,Shanmugam, Y1 - 2017/01/31/ PY - 2016/07/18/received PY - 2017/01/23/accepted PY - 2017/2/1/pubmed PY - 2018/8/15/medline PY - 2017/2/1/entrez KW - Antioxidants KW - Apoptosis KW - Detoxification agents KW - Emodin KW - Lipid peroxidation KW - Oral cancer SP - 19 EP - 29 JF - Pathology oncology research : POR JO - Pathol. Oncol. Res. VL - 24 IS - 1 N2 - The aim of the present study is to focus the chemopreventive potential of Emodin during 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Tumors were developed in the buccal pouches of golden Syrian hamsters by painting with 0.5% DMBA thrice a week for 14 weeks. The status of lipid peroxidation, antioxidants and detoxification agents were utilized as biochemical endpoints and the expression pattern of apoptotic proteins was employed as molecular endpoints in addition to the histopathological studies, to substantiate the anticancer potential of Emodin. Hamsters treated with DMBA + Emodin revealed mild to moderate precancerous lesions such as hyperplasia and dysplasia whereas 100% tumor formation was noticed in hamsters treated with DMBA alone. Also, Emodin treatment modulated the status of lipid peroxidation, antioxidants, phase I and II detoxification agents and apoptotic proteins in favor of the inhibition/reversal/suppression of the oral tumorigenesis in DMBA treated hamsters. The present study thus concludes that the chemopreventive potential of Emodin relies on its pro-apoptotic and antioxidant efficacy during DMBA induced hamster buccal pouch carcinogenesis. SN - 1532-2807 UR - https://www.unboundmedicine.com/medline/citation/28138922/Tumor_Preventive_Efficacy_of_Emodin_in_712_Dimethylbenz[a]Anthracene_Induced_Oral_Carcinogenesis:_a_Histopathological_and_Biochemical_Approach_ L2 - https://doi.org/10.1007/s12253-017-0205-7 DB - PRIME DP - Unbound Medicine ER -