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Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.

Abstract

The aim of the current study was to assess the effects of probiotic supplementation on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome (PCOS). In a randomized, double-blind, placebo-controlled trial, 60 women with PCOS were randomized to receive probiotic capsule (n = 30) or placebo (n = 30) for 12 weeks. Consumption of probiotic supplements resulted in a significant reduction in weight (-0.5 ± 0.4 vs. +0.1 ± 1.0 kg, p = 0.004) and BMI (-0.2 ± 0.2 vs. +0.03 ± 0.4 kg/m2, p = 0.004) compared with the placebo. In addition, compared with the placebo, probiotic administration was associated with a significant decrease in fasting plasma glucose (-2.4 ± 8.4 vs. +2.1 ± 7.0 mg/dL, p = 0.02), serum insulin concentrations (-2.0 ± 5.8 vs. +1.6 ± 5.0 μIU/mL, p = 0.01), homoeostasis model of assessment-insulin resistance (-0.5 ± 1.4 vs. +0.3 ± 1.1, p = 0.01), homoeostatic model assessment-beta cell function (-7.5 ± 22.3 vs. +6.3 ± 21.7, p = 0.01), serum triglycerides (-13.3 ± 51.3 vs. +13.6 ± 37.1 mg/dL, p= 0.02) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (+0.006 ± 0.01 vs. -0.005 ± 0.02, p = 0.01). When we adjusted the analysis for baseline values of biochemical parameters, age and baseline BMI, except for QUICKI (p = 0.08), other findings did not alter. We found that probiotic supplementation among PCOS women for 12 weeks had favourable effects on weight loss, markers of insulin resistance, triglycerides and VLDL-cholesterol concentrations.

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  • Authors+Show Affiliations

    ,

    a Department of Gynecology and Obstetrics, School of Medicine , Iran University of Medical Sciences , Tehran , Iran. b Department of Gynecology and Obstetrics, School of Medicine , Bushehr University of Medical Sciences , Bushehr , Iran.

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    c Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine , Arak University of Medical Sciences , Arak , Iran.

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    a Department of Gynecology and Obstetrics, School of Medicine , Iran University of Medical Sciences , Tehran , Iran.

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    d Science Department, Science Faculty , Islamic Azad University, Tehran Central branch , Tehran , Iran.

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    e Department of Microbiology, Science Faculty , Islamic Azad University, Arak branch , Arak , Iran.

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    f Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.

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    g Barij Medicinal Plants Research Center , Kashan , Iran.

    f Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.

    Source

    Human fertility (Cambridge, England) 20:4 2017 Dec pg 254-261

    MeSH

    Adult
    Blood Glucose
    Dietary Supplements
    Double-Blind Method
    Female
    Humans
    Insulin
    Insulin Resistance
    Lipids
    Polycystic Ovary Syndrome
    Probiotics
    Treatment Outcome
    Weight Loss
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28142296

    Citation

    Ahmadi, Shahnaz, et al. "Probiotic Supplementation and the Effects On Weight Loss, Glycaemia and Lipid Profiles in Women With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial." Human Fertility (Cambridge, England), vol. 20, no. 4, 2017, pp. 254-261.
    Ahmadi S, Jamilian M, Karamali M, et al. Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Hum Fertil (Camb). 2017;20(4):254-261.
    Ahmadi, S., Jamilian, M., Karamali, M., Tajabadi-Ebrahimi, M., Jafari, P., Taghizadeh, M., ... Asemi, Z. (2017). Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Human Fertility (Cambridge, England), 20(4), pp. 254-261. doi:10.1080/14647273.2017.1283446.
    Ahmadi S, et al. Probiotic Supplementation and the Effects On Weight Loss, Glycaemia and Lipid Profiles in Women With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial. Hum Fertil (Camb). 2017;20(4):254-261. PubMed PMID: 28142296.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. AU - Ahmadi,Shahnaz, AU - Jamilian,Mehri, AU - Karamali,Maryam, AU - Tajabadi-Ebrahimi,Maryam, AU - Jafari,Parvaneh, AU - Taghizadeh,Mohsen, AU - Memarzadeh,Mohammad Reza, AU - Asemi,Zatollah, Y1 - 2017/02/01/ PY - 2017/2/2/pubmed PY - 2018/6/26/medline PY - 2017/2/2/entrez KW - Probiotic supplementation KW - glycaemia KW - lipid profiles KW - polycystic ovary syndrome SP - 254 EP - 261 JF - Human fertility (Cambridge, England) JO - Hum Fertil (Camb) VL - 20 IS - 4 N2 - The aim of the current study was to assess the effects of probiotic supplementation on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome (PCOS). In a randomized, double-blind, placebo-controlled trial, 60 women with PCOS were randomized to receive probiotic capsule (n = 30) or placebo (n = 30) for 12 weeks. Consumption of probiotic supplements resulted in a significant reduction in weight (-0.5 ± 0.4 vs. +0.1 ± 1.0 kg, p = 0.004) and BMI (-0.2 ± 0.2 vs. +0.03 ± 0.4 kg/m2, p = 0.004) compared with the placebo. In addition, compared with the placebo, probiotic administration was associated with a significant decrease in fasting plasma glucose (-2.4 ± 8.4 vs. +2.1 ± 7.0 mg/dL, p = 0.02), serum insulin concentrations (-2.0 ± 5.8 vs. +1.6 ± 5.0 μIU/mL, p = 0.01), homoeostasis model of assessment-insulin resistance (-0.5 ± 1.4 vs. +0.3 ± 1.1, p = 0.01), homoeostatic model assessment-beta cell function (-7.5 ± 22.3 vs. +6.3 ± 21.7, p = 0.01), serum triglycerides (-13.3 ± 51.3 vs. +13.6 ± 37.1 mg/dL, p= 0.02) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (+0.006 ± 0.01 vs. -0.005 ± 0.02, p = 0.01). When we adjusted the analysis for baseline values of biochemical parameters, age and baseline BMI, except for QUICKI (p = 0.08), other findings did not alter. We found that probiotic supplementation among PCOS women for 12 weeks had favourable effects on weight loss, markers of insulin resistance, triglycerides and VLDL-cholesterol concentrations. SN - 1742-8149 UR - https://www.unboundmedicine.com/medline/citation/28142296/Probiotic_supplementation_and_the_effects_on_weight_loss_glycaemia_and_lipid_profiles_in_women_with_polycystic_ovary_syndrome:_a_randomized_double_blind_placebo_controlled_trial_ L2 - http://www.tandfonline.com/doi/full/10.1080/14647273.2017.1283446 DB - PRIME DP - Unbound Medicine ER -