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Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation.
J Vet Intern Med. 2017 Mar; 31(2):498-504.JV

Abstract

BACKGROUND

Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL-IVDH) in dogs.

HYPOTHESIS/OBJECTIVES

To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with surgically treated TL-IVDH.

ANIMALS

Six-hundred and fifty-two client-owned dogs evaluated for TL-IVDH that underwent decompressive spinal surgery.

METHODS

Retrospective medical record review from February 2007 through December 2015.

RESULTS

Thirteen dogs developed ADMM, with an overall prevalence of 2.0%. The prevalence of ADMM was 0% in dogs with neurological signs graded 1 or 2 at admission or before magnetic resonance imaging (MRI) or surgical procedures, 0.6% in dogs with neurological signs graded 3, 2.7% in dogs with neurological signs graded 4, and 14.5% in dogs with neurological signs graded 5. Age (<5.8 years), neurological status (grade 5), site of disk herniation (L5-L6), duration of clinical signs before becoming nonambulatory (<24 hours), detection of intramedullary T2-weighted (T2W) hyperintensity, and a T2 length ratio >4.57 were significant risk factors in the univariate analysis for development of ADMM.

CONCLUSIONS AND CLINICAL IMPORTANCE

The factors identified in this study may be useful for the prediction of ADMM. Multicenter studies with a higher number of dogs with ADMM are required to confirm these data.

Authors+Show Affiliations

Neurology Unit, Portoni Rossi Veterinary Hospital, Zola Predosa, Bologna, Italy.Neurology Unit, Portoni Rossi Veterinary Hospital, Zola Predosa, Bologna, Italy. Department of Animal Medicine, Production and Health, Clinical Section, University of Padua, Legnaro, Padua, Italy.Department of Animal Medicine, Production and Health, Clinical Section, University of Padua, Legnaro, Padua, Italy.Neurology Unit, Portoni Rossi Veterinary Hospital, Zola Predosa, Bologna, Italy. Department of Animal Medicine, Production and Health, Clinical Section, University of Padua, Legnaro, Padua, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28144987

Citation

Balducci, F, et al. "Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs After Thoracolumbar Intervertebral Disk Herniation." Journal of Veterinary Internal Medicine, vol. 31, no. 2, 2017, pp. 498-504.
Balducci F, Canal S, Contiero B, et al. Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation. J Vet Intern Med. 2017;31(2):498-504.
Balducci, F., Canal, S., Contiero, B., & Bernardini, M. (2017). Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation. Journal of Veterinary Internal Medicine, 31(2), 498-504. https://doi.org/10.1111/jvim.14656
Balducci F, et al. Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs After Thoracolumbar Intervertebral Disk Herniation. J Vet Intern Med. 2017;31(2):498-504. PubMed PMID: 28144987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation. AU - Balducci,F, AU - Canal,S, AU - Contiero,B, AU - Bernardini,M, Y1 - 2017/02/01/ PY - 2016/09/09/received PY - 2016/12/08/revised PY - 2016/12/14/accepted PY - 2017/2/2/pubmed PY - 2018/3/6/medline PY - 2017/2/2/entrez KW - Canine KW - Contusive injury KW - Deep pain perception KW - Spinal cord injury SP - 498 EP - 504 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 31 IS - 2 N2 - BACKGROUND: Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL-IVDH) in dogs. HYPOTHESIS/OBJECTIVES: To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with surgically treated TL-IVDH. ANIMALS: Six-hundred and fifty-two client-owned dogs evaluated for TL-IVDH that underwent decompressive spinal surgery. METHODS: Retrospective medical record review from February 2007 through December 2015. RESULTS: Thirteen dogs developed ADMM, with an overall prevalence of 2.0%. The prevalence of ADMM was 0% in dogs with neurological signs graded 1 or 2 at admission or before magnetic resonance imaging (MRI) or surgical procedures, 0.6% in dogs with neurological signs graded 3, 2.7% in dogs with neurological signs graded 4, and 14.5% in dogs with neurological signs graded 5. Age (<5.8 years), neurological status (grade 5), site of disk herniation (L5-L6), duration of clinical signs before becoming nonambulatory (<24 hours), detection of intramedullary T2-weighted (T2W) hyperintensity, and a T2 length ratio >4.57 were significant risk factors in the univariate analysis for development of ADMM. CONCLUSIONS AND CLINICAL IMPORTANCE: The factors identified in this study may be useful for the prediction of ADMM. Multicenter studies with a higher number of dogs with ADMM are required to confirm these data. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/28144987/Prevalence_and_Risk_Factors_for_Presumptive_Ascending/Descending_Myelomalacia_in_Dogs_after_Thoracolumbar_Intervertebral_Disk_Herniation_ L2 - https://doi.org/10.1111/jvim.14656 DB - PRIME DP - Unbound Medicine ER -