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Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens.
Clin Vaccine Immunol. 2017 Apr; 24(4)CV

Abstract

Indigenous populations experience high rates of otitis media (OM), with increased chronicity and severity, compared to those experienced by their nonindigenous counterparts. Data on immune responses to otopathogenic bacteria in these high-risk populations are lacking. Nontypeable Haemophilus influenzae (NTHi) is the predominant otopathogen in Australia. No vaccines are currently licensed to target NTHi; however, protein D (PD) from NTHi is included as a carrier protein in the 10-valent pneumococcal polysaccharide conjugate vaccine (PHiD10-CV), and other promising protein vaccine candidates exist, including outer membrane protein 4 (P4) and protein 6 (P6). We measured the levels of serum and salivary IgA and IgG against PD, P4, and P6 in Aboriginal and non-Aboriginal children with chronic OM who were undergoing surgery and compared the levels with those in healthy non-Aboriginal children (controls). We found that Aboriginal cases had lower serum IgG titers to all NTHi proteins assessed, particularly PD. In contrast, serum IgA and salivary IgA and IgG titers to each of these 3 proteins were equivalent to or higher than those in both non-Aboriginal cases and healthy controls. While serum antibody levels increased with age in healthy controls, no changes in titers were observed with age in non-Aboriginal cases, and a trend toward decreasing titers with age was observed in Aboriginal cases. This suggests that decreased serum IgG responses to NTHi outer membrane proteins may contribute to the development of chronic and severe OM in Australian Aboriginal children and other indigenous populations. These data are important for understanding the potential benefits of PHiD10-CV implementation and the development of NTHi protein-based vaccines for indigenous populations.

Authors+Show Affiliations

School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia ruth.thornton@uwa.edu.au. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia. Department of Otorhinolaryngology, Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. School of Public Health, Curtin University, Perth, Western Australia, Australia.PathWest Laboratory Medicine WA, Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia.School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia. Department of Otorhinolaryngology, Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28151410

Citation

Thornton, Ruth B., et al. "Australian Aboriginal Children With Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus Influenzae Vaccine Antigens." Clinical and Vaccine Immunology : CVI, vol. 24, no. 4, 2017.
Thornton RB, Kirkham LS, Corscadden KJ, et al. Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens. Clin Vaccine Immunol. 2017;24(4).
Thornton, R. B., Kirkham, L. S., Corscadden, K. J., Wiertsema, S. P., Fuery, A., Jones, B. J., Coates, H. L., Vijayasekaran, S., Zhang, G., Keil, A., & Richmond, P. C. (2017). Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens. Clinical and Vaccine Immunology : CVI, 24(4). https://doi.org/10.1128/CVI.00556-16
Thornton RB, et al. Australian Aboriginal Children With Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus Influenzae Vaccine Antigens. Clin Vaccine Immunol. 2017;24(4) PubMed PMID: 28151410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens. AU - Thornton,Ruth B, AU - Kirkham,Lea-Ann S, AU - Corscadden,Karli J, AU - Wiertsema,Selma P, AU - Fuery,Angela, AU - Jones,B Jan, AU - Coates,Harvey L, AU - Vijayasekaran,Shyan, AU - Zhang,Guicheng, AU - Keil,Anthony, AU - Richmond,Peter C, Y1 - 2017/04/05/ PY - 2016/12/16/received PY - 2017/01/23/accepted PY - 2017/2/6/pubmed PY - 2017/9/13/medline PY - 2017/2/3/entrez KW - Australian Aboriginal KW - antibody KW - indigenous KW - nontypeable Haemophilus influenzae KW - vaccines JF - Clinical and vaccine immunology : CVI JO - Clin Vaccine Immunol VL - 24 IS - 4 N2 - Indigenous populations experience high rates of otitis media (OM), with increased chronicity and severity, compared to those experienced by their nonindigenous counterparts. Data on immune responses to otopathogenic bacteria in these high-risk populations are lacking. Nontypeable Haemophilus influenzae (NTHi) is the predominant otopathogen in Australia. No vaccines are currently licensed to target NTHi; however, protein D (PD) from NTHi is included as a carrier protein in the 10-valent pneumococcal polysaccharide conjugate vaccine (PHiD10-CV), and other promising protein vaccine candidates exist, including outer membrane protein 4 (P4) and protein 6 (P6). We measured the levels of serum and salivary IgA and IgG against PD, P4, and P6 in Aboriginal and non-Aboriginal children with chronic OM who were undergoing surgery and compared the levels with those in healthy non-Aboriginal children (controls). We found that Aboriginal cases had lower serum IgG titers to all NTHi proteins assessed, particularly PD. In contrast, serum IgA and salivary IgA and IgG titers to each of these 3 proteins were equivalent to or higher than those in both non-Aboriginal cases and healthy controls. While serum antibody levels increased with age in healthy controls, no changes in titers were observed with age in non-Aboriginal cases, and a trend toward decreasing titers with age was observed in Aboriginal cases. This suggests that decreased serum IgG responses to NTHi outer membrane proteins may contribute to the development of chronic and severe OM in Australian Aboriginal children and other indigenous populations. These data are important for understanding the potential benefits of PHiD10-CV implementation and the development of NTHi protein-based vaccines for indigenous populations. SN - 1556-679X UR - https://www.unboundmedicine.com/medline/citation/28151410/Australian_Aboriginal_Children_with_Otitis_Media_Have_Reduced_Antibody_Titers_to_Specific_Nontypeable_Haemophilus_influenzae_Vaccine_Antigens_ DB - PRIME DP - Unbound Medicine ER -