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Preparation for radioactive iodine therapy is not a risk factor for the development of hyponatremia in thyroid cancer patients.
Medicine (Baltimore) 2017; 96(5):e6004M

Abstract

The aim of this study was to evaluate whether the preparation for radioactive iodine (RAI) therapy by thyroid hormone withdrawal (THW) or a low-iodine diet (LID) can be risk factors for the development of hyponatremia in patients with differentiated thyroid cancer after thyroidectomy.We retrospectively reviewed the medical records and laboratory findings of 326 patients who underwent preparation for RAI therapy after thyroidectomy from 2012 to 2014. Demographic and clinical variables including the method of thyrotropin stimulation and duration of LID were assessed. Serum sodium was measured twice, before operation and before RAI therapy.Hyponatremia was detected in only 3 patients (0.9%) before operation, but in 15 patients (4.6%) before RAI therapy. None of the patients had severe hyponatremia after preparation for RAI therapy. Pre-RAI therapy serum sodium was correlated with the method of thyrotropin stimulation (TWH vs recombinant human thyroid stimulating hormone, P = 0.014) and duration of LID (r = -0.131, P = 0.018); however, the preparation of RAI therapy, THW and LID, did not affect the development of hyponatremia in logistic regression analysis. Preoperative serum sodium was a significant risk factor for hyponatremia during preparation for RAI therapy.Preparation for RAI therapy by THW or LID is not a risk factor for the development of hyponatremia in patients with thyroid cancer. The development of hyponatremia was neither frequent nor severe during preparation for RAI therapy. Physicians should not be greatly concerned about rare life-threatening hyponatremia during preparation for RAI therapy.

Authors+Show Affiliations

aDepartment of Nuclear Medicine, Chonnam National University Hospital bDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital cDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Hospital dDepartment of Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

28151897

Citation

Kim, Jahae, et al. "Preparation for Radioactive Iodine Therapy Is Not a Risk Factor for the Development of Hyponatremia in Thyroid Cancer Patients." Medicine, vol. 96, no. 5, 2017, pp. e6004.
Kim J, Cho SG, Kang SR, et al. Preparation for radioactive iodine therapy is not a risk factor for the development of hyponatremia in thyroid cancer patients. Medicine (Baltimore). 2017;96(5):e6004.
Kim, J., Cho, S. G., Kang, S. R., Kwon, S. Y., Cho, D. H., Cho, J. S., & Song, H. C. (2017). Preparation for radioactive iodine therapy is not a risk factor for the development of hyponatremia in thyroid cancer patients. Medicine, 96(5), pp. e6004. doi:10.1097/MD.0000000000006004.
Kim J, et al. Preparation for Radioactive Iodine Therapy Is Not a Risk Factor for the Development of Hyponatremia in Thyroid Cancer Patients. Medicine (Baltimore). 2017;96(5):e6004. PubMed PMID: 28151897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation for radioactive iodine therapy is not a risk factor for the development of hyponatremia in thyroid cancer patients. AU - Kim,Jahae, AU - Cho,Sang-Geon, AU - Kang,Sae-Ryung, AU - Kwon,Seong Young, AU - Cho,Dong-Hyeok, AU - Cho,Jin-Seong, AU - Song,Ho-Chun, PY - 2017/2/3/entrez PY - 2017/2/6/pubmed PY - 2017/2/23/medline SP - e6004 EP - e6004 JF - Medicine JO - Medicine (Baltimore) VL - 96 IS - 5 N2 - The aim of this study was to evaluate whether the preparation for radioactive iodine (RAI) therapy by thyroid hormone withdrawal (THW) or a low-iodine diet (LID) can be risk factors for the development of hyponatremia in patients with differentiated thyroid cancer after thyroidectomy.We retrospectively reviewed the medical records and laboratory findings of 326 patients who underwent preparation for RAI therapy after thyroidectomy from 2012 to 2014. Demographic and clinical variables including the method of thyrotropin stimulation and duration of LID were assessed. Serum sodium was measured twice, before operation and before RAI therapy.Hyponatremia was detected in only 3 patients (0.9%) before operation, but in 15 patients (4.6%) before RAI therapy. None of the patients had severe hyponatremia after preparation for RAI therapy. Pre-RAI therapy serum sodium was correlated with the method of thyrotropin stimulation (TWH vs recombinant human thyroid stimulating hormone, P = 0.014) and duration of LID (r = -0.131, P = 0.018); however, the preparation of RAI therapy, THW and LID, did not affect the development of hyponatremia in logistic regression analysis. Preoperative serum sodium was a significant risk factor for hyponatremia during preparation for RAI therapy.Preparation for RAI therapy by THW or LID is not a risk factor for the development of hyponatremia in patients with thyroid cancer. The development of hyponatremia was neither frequent nor severe during preparation for RAI therapy. Physicians should not be greatly concerned about rare life-threatening hyponatremia during preparation for RAI therapy. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/28151897/Preparation_for_radioactive_iodine_therapy_is_not_a_risk_factor_for_the_development_of_hyponatremia_in_thyroid_cancer_patients_ L2 - http://Insights.ovid.com/pubmed?pmid=28151897 DB - PRIME DP - Unbound Medicine ER -