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Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.
Psychiatry Res. 2017 Mar; 249:349-353.PR

Abstract

This study aimed to evaluate the effectiveness of electroconvulsive therapy (ECT) among patients with treatment resistant schizophrenia (TRS). Records of patients who had received ECT were reviewed to identify patients with TRS who were administered ECT in combination with clozapine. Socio-demographic, clinical data and ECT details were extracted. The most common diagnosis was of paranoid schizophrenia (49%) followed by undifferentiated schizophrenia (36%). A-fifth (22%) of the patients were judged to have poor response to clozapine. The mean number of ECTs given were 13.97 (SD-7.67) and mean clozapine dose was 287.5mgs/day (SD-100.1). About two-thirds (63%) of the patients showed >30% reduction in scores on different symptom-rating scales with combined use of clozapine and ECT. Among clozapine non-responders, approximately 69% responded to the combination. Post-ECT rise in blood pressure was the most common side effect (16.9%) followed by prolonged seizures (7%). Long-term follow-up data was available for 47 out of the 59 patients. More than two-third (N=34; 72%) followed-up for an average of 30 months (SD 32.3; range: 1-120), maintained well with continued clozapine treatment. To conclude, results of this study further endorse the effectiveness, safety and long-term benefits of the clozapine-ECT combination in TRS and clozapine-refractory schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Post-Graduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address: drsandeepg2002@yahoo.com.Department of Psychiatry, Post-Graduate Institute of Medical Education and Research, Chandigarh 160012, India.Department of Psychiatry, Post-Graduate Institute of Medical Education and Research, Chandigarh 160012, India.Department of Psychiatry, Post-Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28152470

Citation

Grover, Sandeep, et al. "Effectiveness of Electroconvulsive Therapy in Patients With Treatment Resistant Schizophrenia: a Retrospective Study." Psychiatry Research, vol. 249, 2017, pp. 349-353.
Grover S, Chakrabarti S, Hazari N, et al. Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study. Psychiatry Res. 2017;249:349-353.
Grover, S., Chakrabarti, S., Hazari, N., & Avasthi, A. (2017). Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study. Psychiatry Research, 249, 349-353. https://doi.org/10.1016/j.psychres.2017.01.042
Grover S, et al. Effectiveness of Electroconvulsive Therapy in Patients With Treatment Resistant Schizophrenia: a Retrospective Study. Psychiatry Res. 2017;249:349-353. PubMed PMID: 28152470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study. AU - Grover,Sandeep, AU - Chakrabarti,Subho, AU - Hazari,Nandita, AU - Avasthi,Ajit, Y1 - 2017/01/18/ PY - 2016/04/16/received PY - 2016/11/05/revised PY - 2017/01/17/accepted PY - 2017/2/6/pubmed PY - 2017/11/9/medline PY - 2017/2/3/entrez KW - Clozapine KW - Clozapine non-response KW - Electroconvulsive therapy KW - Schizophrenia KW - Treatment-resistant SP - 349 EP - 353 JF - Psychiatry research JO - Psychiatry Res VL - 249 N2 - This study aimed to evaluate the effectiveness of electroconvulsive therapy (ECT) among patients with treatment resistant schizophrenia (TRS). Records of patients who had received ECT were reviewed to identify patients with TRS who were administered ECT in combination with clozapine. Socio-demographic, clinical data and ECT details were extracted. The most common diagnosis was of paranoid schizophrenia (49%) followed by undifferentiated schizophrenia (36%). A-fifth (22%) of the patients were judged to have poor response to clozapine. The mean number of ECTs given were 13.97 (SD-7.67) and mean clozapine dose was 287.5mgs/day (SD-100.1). About two-thirds (63%) of the patients showed >30% reduction in scores on different symptom-rating scales with combined use of clozapine and ECT. Among clozapine non-responders, approximately 69% responded to the combination. Post-ECT rise in blood pressure was the most common side effect (16.9%) followed by prolonged seizures (7%). Long-term follow-up data was available for 47 out of the 59 patients. More than two-third (N=34; 72%) followed-up for an average of 30 months (SD 32.3; range: 1-120), maintained well with continued clozapine treatment. To conclude, results of this study further endorse the effectiveness, safety and long-term benefits of the clozapine-ECT combination in TRS and clozapine-refractory schizophrenia. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/28152470/Effectiveness_of_electroconvulsive_therapy_in_patients_with_treatment_resistant_schizophrenia:_A_retrospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(16)30653-9 DB - PRIME DP - Unbound Medicine ER -