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Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: A Case Report and Literature Review.
Intern Med. 2017; 56(3):357-362.IM

Abstract

We describe a 24-year-old woman with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that developed 3 weeks after normal delivery. She was treated with methylprednisolone, intravenous immunoglobulin, and plasmapheresis, in addition to teratoma excision. However, her recovery was slow, and dysmnesia and mental juvenility persisted even two years after onset. To date, five patients with postpartum anti-NMDAR encephalitis have been reported. All of those patients showed psychotic symptoms and were suspected of having postpartum psychosis in the early period of the encephalitis. Changes in hormonal factors, modification of immune tolerance, or retrograde infection of the ovary may be contributing factors for postpartum anti-NMDAR encephalitis.

Links

Publisher Full Text
ncbi.nlm.nih.gov
dx.doi.org
PMC Free PDF

Authors+Show Affiliations

Doden T
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Sekijima Y
No affiliation info available
Ikeda J
No affiliation info available
Ozawa K
No affiliation info available
Ohashi N
No affiliation info available
Kodaira M
No affiliation info available
Hineno A
No affiliation info available
Tachibana N
No affiliation info available
Ikeda SI
No affiliation info available

MeSH

AdolescentAnti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesFemaleHumansImmunoglobulins, IntravenousPostpartum PeriodPsychotic DisordersReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

28154283

Citation

Doden, Tadashi, et al. "Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: a Case Report and Literature Review." Internal Medicine (Tokyo, Japan), vol. 56, no. 3, 2017, pp. 357-362.
Doden T, Sekijima Y, Ikeda J, et al. Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: A Case Report and Literature Review. Intern Med. 2017;56(3):357-362.
Doden, T., Sekijima, Y., Ikeda, J., Ozawa, K., Ohashi, N., Kodaira, M., Hineno, A., Tachibana, N., & Ikeda, S. I. (2017). Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: A Case Report and Literature Review. Internal Medicine (Tokyo, Japan), 56(3), 357-362. https://doi.org/10.2169/internalmedicine.56.7442
Doden T, et al. Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: a Case Report and Literature Review. Intern Med. 2017;56(3):357-362. PubMed PMID: 28154283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: A Case Report and Literature Review. AU - Doden,Tadashi, AU - Sekijima,Yoshiki, AU - Ikeda,Junji, AU - Ozawa,Kazuki, AU - Ohashi,Nobuhiko, AU - Kodaira,Minori, AU - Hineno,Akiyo, AU - Tachibana,Naoko, AU - Ikeda,Shu-Ichi, Y1 - 2017/02/01/ PY - 2017/2/4/entrez PY - 2017/2/6/pubmed PY - 2017/3/7/medline SP - 357 EP - 362 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 56 IS - 3 N2 - We describe a 24-year-old woman with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that developed 3 weeks after normal delivery. She was treated with methylprednisolone, intravenous immunoglobulin, and plasmapheresis, in addition to teratoma excision. However, her recovery was slow, and dysmnesia and mental juvenility persisted even two years after onset. To date, five patients with postpartum anti-NMDAR encephalitis have been reported. All of those patients showed psychotic symptoms and were suspected of having postpartum psychosis in the early period of the encephalitis. Changes in hormonal factors, modification of immune tolerance, or retrograde infection of the ovary may be contributing factors for postpartum anti-NMDAR encephalitis. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/28154283/Postpartum_Anti_N_methyl_D_aspartate_Receptor_Encephalitis:_A_Case_Report_and_Literature_Review_ L2 - https://dx.doi.org/10.2169/internalmedicine.56.7442 DB - PRIME DP - Unbound Medicine ER -