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The Association Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease.
Curr Gastroenterol Rep. 2017 Feb; 19(2):5.CG

Abstract

PURPOSE OF REVIEW

Helicobacter pylori (HP) infection is known to be a significant risk factor in the development of certain gastric conditions, such as ulcers, gastritis, and malignancy. Recently, however, the systemic effect of HP infection on other organ systems has come to be appreciated. In this review, we will explore the association between HP infection and nonalcoholic fatty liver disease (NAFLD), the hepatic component of metabolic syndrome.

RECENT FINDINGS

The possible association between HP infection and NAFLD initially stemmed from the isolation of HP bacteria in the livers of patients with NAFLD. Although there have been conflicting results, several subsequent clinical trials have demonstrated a higher rate of fatty liver and NASH in HP-positive patients compared to HP-negative patients; in addition, small trials examining the effect of HP eradication have shown improvement in markers of NAFLD activity, further supporting a link between these two conditions. The pathophysiology behind the possible association between HP infection and NAFLD has yet to be fully elucidated; several possible mechanisms include induction of a pro-inflammatory state that shifts the body toward a more lipogenic profile, and a hormonal shift that favors progression toward insulin resistance and fibrosis. The association between HP infection and NAFLD has been demonstrated in several clinical trials, including small trials evaluating the effect of HP eradication on NAFLD. Future studies examining the pathophysiology behind this association are the next step in characterizing the relationship between these two conditions.

Authors+Show Affiliations

Division of Gastroenterology, Southern California Permanente Medical Group, Kaiser Permanente, Orange County, Anaheim, CA, USA.Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9C-101, Bethesda, MD, 20892, USA. sheila.kumar@nih.gov.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28155087

Citation

Tang, Derek M., and Sheila Kumar. "The Association Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease." Current Gastroenterology Reports, vol. 19, no. 2, 2017, p. 5.
Tang DM, Kumar S. The Association Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease. Curr Gastroenterol Rep. 2017;19(2):5.
Tang, D. M., & Kumar, S. (2017). The Association Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease. Current Gastroenterology Reports, 19(2), 5. https://doi.org/10.1007/s11894-017-0545-1
Tang DM, Kumar S. The Association Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease. Curr Gastroenterol Rep. 2017;19(2):5. PubMed PMID: 28155087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease. AU - Tang,Derek M, AU - Kumar,Sheila, PY - 2017/2/4/entrez PY - 2017/2/6/pubmed PY - 2017/2/14/medline KW - Helicobacter pylori KW - Nonalcoholic fatty liver disease KW - Nonalcoholic steatohepatitis SP - 5 EP - 5 JF - Current gastroenterology reports JO - Curr Gastroenterol Rep VL - 19 IS - 2 N2 - PURPOSE OF REVIEW: Helicobacter pylori (HP) infection is known to be a significant risk factor in the development of certain gastric conditions, such as ulcers, gastritis, and malignancy. Recently, however, the systemic effect of HP infection on other organ systems has come to be appreciated. In this review, we will explore the association between HP infection and nonalcoholic fatty liver disease (NAFLD), the hepatic component of metabolic syndrome. RECENT FINDINGS: The possible association between HP infection and NAFLD initially stemmed from the isolation of HP bacteria in the livers of patients with NAFLD. Although there have been conflicting results, several subsequent clinical trials have demonstrated a higher rate of fatty liver and NASH in HP-positive patients compared to HP-negative patients; in addition, small trials examining the effect of HP eradication have shown improvement in markers of NAFLD activity, further supporting a link between these two conditions. The pathophysiology behind the possible association between HP infection and NAFLD has yet to be fully elucidated; several possible mechanisms include induction of a pro-inflammatory state that shifts the body toward a more lipogenic profile, and a hormonal shift that favors progression toward insulin resistance and fibrosis. The association between HP infection and NAFLD has been demonstrated in several clinical trials, including small trials evaluating the effect of HP eradication on NAFLD. Future studies examining the pathophysiology behind this association are the next step in characterizing the relationship between these two conditions. SN - 1534-312X UR - https://www.unboundmedicine.com/medline/citation/28155087/The_Association_Between_Helicobacter_pylori_Infection_and_Nonalcoholic_Fatty_Liver_Disease_ L2 - https://dx.doi.org/10.1007/s11894-017-0545-1 DB - PRIME DP - Unbound Medicine ER -