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SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries.
Biomed Eng Online 2016; 15(Suppl 2):161BE

Abstract

BACKGROUND

Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shapes. Computational modelling techniques can be used to successfully predict the behaviour of the RBCs in capillaries. In this study, we report the application of a meshfree particle approach to model and predict the motion and deformation of three-dimensional RBCs in capillaries.

METHODS

An elastic spring network based on the discrete element method (DEM) is employed to model the three-dimensional RBC membrane. The haemoglobin in the RBC and the plasma in the blood are modelled as smoothed particle hydrodynamics (SPH) particles. For validation purposes, the behaviour of a single RBC in a simple shear flow is examined and compared against experimental results. Then simulations are carried out to predict the behaviour of RBCs in a capillary; (i) the motion of five identical RBCs in a uniform capillary, (ii) the motion of five identical RBCs with different bending stiffness (K b) values in a stenosed capillary, (iii) the motion of three RBCs in a narrow capillary. Finally five identical RBCs are employed to determine the critical diameter of a stenosed capillary.

RESULTS

Validation results showed a good agreement with less than 10% difference. From the above simulations, the following results are obtained; (i) RBCs exhibit different deformation behaviours due to the hydrodynamic interaction between them. (ii) Asymmetrical deformation behaviours of the RBCs are clearly observed when the bending stiffness (K b) of the RBCs is changed. (iii) The model predicts the ability of the RBCs to squeeze through smaller blood vessels. Finally, from the simulations, the critical diameter of the stenosed section to stop the motion of blood flow is predicted.

CONCLUSIONS

A three-dimensional spring network model based on DEM in combination with the SPH method is successfully used to model the motion and deformation of RBCs in capillaries. Simulation results reveal that the condition of blood flow stopping depends on the pressure gradient of the capillary and the severity of stenosis of the capillary. In addition, this model is capable of predicting the critical diameter which prevents motion of RBCs for different blood pressures.

Authors+Show Affiliations

School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, 2-George Street, Brisbane, QLD, 4001, Australia.School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, 2-George Street, Brisbane, QLD, 4001, Australia.School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, 2-George Street, Brisbane, QLD, 4001, Australia.Research and Development, Australian Red Cross Blood Service, Kelvin Grove, QLD, 4059, Australia.School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, 2-George Street, Brisbane, QLD, 4001, Australia.School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, 2-George Street, Brisbane, QLD, 4001, Australia. yuantong.gu@qut.edu.au.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28155717

Citation

Polwaththe-Gallage, Hasitha-Nayanajith, et al. "SPH-DEM Approach to Numerically Simulate the Deformation of Three-dimensional RBCs in Non-uniform Capillaries." Biomedical Engineering Online, vol. 15, no. Suppl 2, 2016, p. 161.
Polwaththe-Gallage HN, Saha SC, Sauret E, et al. SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries. Biomed Eng Online. 2016;15(Suppl 2):161.
Polwaththe-Gallage, H. N., Saha, S. C., Sauret, E., Flower, R., Senadeera, W., & Gu, Y. (2016). SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries. Biomedical Engineering Online, 15(Suppl 2), p. 161. doi:10.1186/s12938-016-0256-0.
Polwaththe-Gallage HN, et al. SPH-DEM Approach to Numerically Simulate the Deformation of Three-dimensional RBCs in Non-uniform Capillaries. Biomed Eng Online. 2016 Dec 28;15(Suppl 2):161. PubMed PMID: 28155717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries. AU - Polwaththe-Gallage,Hasitha-Nayanajith, AU - Saha,Suvash C, AU - Sauret,Emilie, AU - Flower,Robert, AU - Senadeera,Wijitha, AU - Gu,YuanTong, Y1 - 2016/12/28/ PY - 2017/2/4/entrez PY - 2017/2/6/pubmed PY - 2017/3/3/medline KW - Blood flow KW - Computational biomechanics KW - Critical diameter KW - Discrete element method KW - Meshfree method KW - Multiple red blood cells KW - Smoothed particle hydrodynamics SP - 161 EP - 161 JF - Biomedical engineering online JO - Biomed Eng Online VL - 15 IS - Suppl 2 N2 - BACKGROUND: Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shapes. Computational modelling techniques can be used to successfully predict the behaviour of the RBCs in capillaries. In this study, we report the application of a meshfree particle approach to model and predict the motion and deformation of three-dimensional RBCs in capillaries. METHODS: An elastic spring network based on the discrete element method (DEM) is employed to model the three-dimensional RBC membrane. The haemoglobin in the RBC and the plasma in the blood are modelled as smoothed particle hydrodynamics (SPH) particles. For validation purposes, the behaviour of a single RBC in a simple shear flow is examined and compared against experimental results. Then simulations are carried out to predict the behaviour of RBCs in a capillary; (i) the motion of five identical RBCs in a uniform capillary, (ii) the motion of five identical RBCs with different bending stiffness (K b) values in a stenosed capillary, (iii) the motion of three RBCs in a narrow capillary. Finally five identical RBCs are employed to determine the critical diameter of a stenosed capillary. RESULTS: Validation results showed a good agreement with less than 10% difference. From the above simulations, the following results are obtained; (i) RBCs exhibit different deformation behaviours due to the hydrodynamic interaction between them. (ii) Asymmetrical deformation behaviours of the RBCs are clearly observed when the bending stiffness (K b) of the RBCs is changed. (iii) The model predicts the ability of the RBCs to squeeze through smaller blood vessels. Finally, from the simulations, the critical diameter of the stenosed section to stop the motion of blood flow is predicted. CONCLUSIONS: A three-dimensional spring network model based on DEM in combination with the SPH method is successfully used to model the motion and deformation of RBCs in capillaries. Simulation results reveal that the condition of blood flow stopping depends on the pressure gradient of the capillary and the severity of stenosis of the capillary. In addition, this model is capable of predicting the critical diameter which prevents motion of RBCs for different blood pressures. SN - 1475-925X UR - https://www.unboundmedicine.com/medline/citation/28155717/SPH_DEM_approach_to_numerically_simulate_the_deformation_of_three_dimensional_RBCs_in_non_uniform_capillaries_ L2 - https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/s12938-016-0256-0 DB - PRIME DP - Unbound Medicine ER -