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Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome).
Clin Chest Med. 2017 Mar; 38(1):71-86.CC

Abstract

Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy.

Authors+Show Affiliations

Department of Medicine & Therapeutics, Stanley Ho Center for Emerging Infectious Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. Electronic address: dschui@cuhk.edu.hk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28159163

Citation

Hui, David S.. "Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)." Clinics in Chest Medicine, vol. 38, no. 1, 2017, pp. 71-86.
Hui DS. Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). Clin Chest Med. 2017;38(1):71-86.
Hui, D. S. (2017). Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). Clinics in Chest Medicine, 38(1), 71-86. https://doi.org/10.1016/j.ccm.2016.11.007
Hui DS. Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). Clin Chest Med. 2017;38(1):71-86. PubMed PMID: 28159163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). A1 - Hui,David S, Y1 - 2016/12/16/ PY - 2017/2/5/entrez PY - 2017/2/6/pubmed PY - 2017/10/3/medline KW - Clinical features KW - MERS-CoV KW - Pathogenesis KW - Respiratory tract infections KW - SARS-CoV KW - Treatment SP - 71 EP - 86 JF - Clinics in chest medicine JO - Clin Chest Med VL - 38 IS - 1 N2 - Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy. SN - 1557-8216 UR - https://www.unboundmedicine.com/medline/citation/28159163/Epidemic_and_Emerging_Coronaviruses__Severe_Acute_Respiratory_Syndrome_and_Middle_East_Respiratory_Syndrome__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-5231(16)30128-9 DB - PRIME DP - Unbound Medicine ER -