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New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases.
Metabolism. 2017 Apr; 69S:S3-S7.M

Abstract

Access to the CNS and delivery of therapeutics across the blood-brain barrier remains a challenge for most treatments of major neurological diseases such as AD or PD. Focused ultrasound represents a potential approach for overcoming these barriers to treating AD and PD and perhaps other neurological diseases. Ultrasound (US) is best known for its imaging capabilities of organs in the periphery, but various arrangements of the transducers producing the acoustic signal allow the energy to be precisely focused (F) within the skull. Using FUS in combination with MRI and contrast agents further enhances accuracy by providing clear information on location. Varying the acoustic power allows FUS to be used in applications ranging from imaging, stimulation of brain circuits, to ablation of tissue. In several transgenic mouse models of AD, the use of FUS with microbubbles reduces plaque load and improves cognition and suggests the need to investigate this technology for plaque removal in AD. In PD, FUS is being explored as a way to non-invasively ablate the brain areas responsible for the tremor and dyskinesia associated with the disease, but has yet to be utilized for non-invasive delivery of putative therapeutics. The FUS approach also greatly increases the range of possible CNS therapeutics as it overcomes the issues of BBB penetration. In this review we discuss how the characteristics and various applications of FUS may advance the therapeutics available for treating or preventing neurodegenerative disorders with an emphasis on treating AD and PD.

Authors+Show Affiliations

Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505. Electronic address: dum6@cdc.gov.Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505. Electronic address: jdo5@cdc.gov.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28159329

Citation

Miller, Diane B., and James P. O'Callaghan. "New Horizons for Focused Ultrasound (FUS) - Therapeutic Applications in Neurodegenerative Diseases." Metabolism: Clinical and Experimental, vol. 69S, 2017, pp. S3-S7.
Miller DB, O'Callaghan JP. New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. Metabolism. 2017;69S:S3-S7.
Miller, D. B., & O'Callaghan, J. P. (2017). New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. Metabolism: Clinical and Experimental, 69S, S3-S7. https://doi.org/10.1016/j.metabol.2017.01.012
Miller DB, O'Callaghan JP. New Horizons for Focused Ultrasound (FUS) - Therapeutic Applications in Neurodegenerative Diseases. Metabolism. 2017;69S:S3-S7. PubMed PMID: 28159329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. AU - Miller,Diane B, AU - O'Callaghan,James P, Y1 - 2017/01/11/ PY - 2017/2/6/pubmed PY - 2017/5/16/medline PY - 2017/2/5/entrez KW - Microbubbles KW - Obicodilation KW - Sonothrombolysis KW - Transcalvarial FUS KW - Transcranial SP - S3 EP - S7 JF - Metabolism: clinical and experimental JO - Metabolism VL - 69S N2 - Access to the CNS and delivery of therapeutics across the blood-brain barrier remains a challenge for most treatments of major neurological diseases such as AD or PD. Focused ultrasound represents a potential approach for overcoming these barriers to treating AD and PD and perhaps other neurological diseases. Ultrasound (US) is best known for its imaging capabilities of organs in the periphery, but various arrangements of the transducers producing the acoustic signal allow the energy to be precisely focused (F) within the skull. Using FUS in combination with MRI and contrast agents further enhances accuracy by providing clear information on location. Varying the acoustic power allows FUS to be used in applications ranging from imaging, stimulation of brain circuits, to ablation of tissue. In several transgenic mouse models of AD, the use of FUS with microbubbles reduces plaque load and improves cognition and suggests the need to investigate this technology for plaque removal in AD. In PD, FUS is being explored as a way to non-invasively ablate the brain areas responsible for the tremor and dyskinesia associated with the disease, but has yet to be utilized for non-invasive delivery of putative therapeutics. The FUS approach also greatly increases the range of possible CNS therapeutics as it overcomes the issues of BBB penetration. In this review we discuss how the characteristics and various applications of FUS may advance the therapeutics available for treating or preventing neurodegenerative disorders with an emphasis on treating AD and PD. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/28159329/New_horizons_for_focused_ultrasound__FUS____therapeutic_applications_in_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(17)30016-1 DB - PRIME DP - Unbound Medicine ER -