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Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses.
J Gastroenterol Hepatol. 2017 Sep; 32(9):1553-1561.JG

Abstract

BACKGROUND AND AIM

Coexistent gastrointestinal symptom profiles and prevalence or associated factors for the overlap between each functional dyspepsia (FD) and irritable bowel syndrome (IBS) group remain unclear. Thus, the aim of the present study was to evaluate the clinicodemographic features of FD, IBS, and IBS-FD overlap and assess the risk factors thereof, including subtype and genetic polymorphisms for IBS-FD.

METHODS

Consecutive patients were enrolled from the outpatient Gastroenterology clinics of Bundang Seoul National University Hospitals in Korea. All gastrointestinal symptoms occurring at least once per week in the previous 3 months were recorded. Diagnostic criteria of functional gastrointestinal disorders were based on the Rome III criteria. Risk factors including genetic polymorphisms of 5-HTTLPR and ADRA2A 1291 G alleles and CCK-1R intron 779T>C were assessed using a multivariate logistic regression model.

RESULTS

A total of 632 subjects (278 control subjects, 308 FD, 156 IBS, and 110 who met the criteria for both FD and IBS) were included in this study. Patients with IBS-FD overlap had more severe symptoms (such as bloating, nausea, vomiting, hard or lumpy stools, defecation straining, and a feeling of incomplete bowel movement) and higher depression scores compared with non-overlap patients. Single/divorced or widowed marital status, nausea, bloating, and a feeling of incomplete emptying after bowel movements were independent risk factors for IBS-FD overlap among IBS patients. In contrast, young age, depression, bloating, and postprandial distress syndrome were positively associated with IBS-FD overlap among FD patients. 5-HTTLPR L/L was a risk factor for the co-occurrence of IBS-C among FD patients (OR: 12.47; 95% CI: 2.00-77.75; P = 0.007).

CONCLUSIONS

Bloating was a risk factor for IBS-FD overlap. Patients with postprandial distress syndrome have a higher risk of coexisting IBS, particularly constipation-dominant IBS.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.Department of Gastroenterology, Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28160607

Citation

Choi, Yoon Jin, et al. "Overlap Between Irritable Bowel Syndrome and Functional Dyspepsia Including Subtype Analyses." Journal of Gastroenterology and Hepatology, vol. 32, no. 9, 2017, pp. 1553-1561.
Choi YJ, Kim N, Yoon H, et al. Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses. J Gastroenterol Hepatol. 2017;32(9):1553-1561.
Choi, Y. J., Kim, N., Yoon, H., Shin, C. M., Park, Y. S., Kim, J. W., Kim, Y. S., Lee, D. H., & Jung, H. C. (2017). Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses. Journal of Gastroenterology and Hepatology, 32(9), 1553-1561. https://doi.org/10.1111/jgh.13756
Choi YJ, et al. Overlap Between Irritable Bowel Syndrome and Functional Dyspepsia Including Subtype Analyses. J Gastroenterol Hepatol. 2017;32(9):1553-1561. PubMed PMID: 28160607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses. AU - Choi,Yoon Jin, AU - Kim,Nayoung, AU - Yoon,Hyuk, AU - Shin,Cheol Min, AU - Park,Young Soo, AU - Kim,Jin-Wook, AU - Kim,Yong Sung, AU - Lee,Dong Ho, AU - Jung,Hyun Chae, PY - 2016/09/02/received PY - 2016/12/16/revised PY - 2017/01/23/accepted PY - 2017/2/6/pubmed PY - 2018/3/1/medline PY - 2017/2/5/entrez KW - bloating KW - depression KW - functional dyspepsia KW - irritable bowel syndrome SP - 1553 EP - 1561 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 32 IS - 9 N2 - BACKGROUND AND AIM: Coexistent gastrointestinal symptom profiles and prevalence or associated factors for the overlap between each functional dyspepsia (FD) and irritable bowel syndrome (IBS) group remain unclear. Thus, the aim of the present study was to evaluate the clinicodemographic features of FD, IBS, and IBS-FD overlap and assess the risk factors thereof, including subtype and genetic polymorphisms for IBS-FD. METHODS: Consecutive patients were enrolled from the outpatient Gastroenterology clinics of Bundang Seoul National University Hospitals in Korea. All gastrointestinal symptoms occurring at least once per week in the previous 3 months were recorded. Diagnostic criteria of functional gastrointestinal disorders were based on the Rome III criteria. Risk factors including genetic polymorphisms of 5-HTTLPR and ADRA2A 1291 G alleles and CCK-1R intron 779T>C were assessed using a multivariate logistic regression model. RESULTS: A total of 632 subjects (278 control subjects, 308 FD, 156 IBS, and 110 who met the criteria for both FD and IBS) were included in this study. Patients with IBS-FD overlap had more severe symptoms (such as bloating, nausea, vomiting, hard or lumpy stools, defecation straining, and a feeling of incomplete bowel movement) and higher depression scores compared with non-overlap patients. Single/divorced or widowed marital status, nausea, bloating, and a feeling of incomplete emptying after bowel movements were independent risk factors for IBS-FD overlap among IBS patients. In contrast, young age, depression, bloating, and postprandial distress syndrome were positively associated with IBS-FD overlap among FD patients. 5-HTTLPR L/L was a risk factor for the co-occurrence of IBS-C among FD patients (OR: 12.47; 95% CI: 2.00-77.75; P = 0.007). CONCLUSIONS: Bloating was a risk factor for IBS-FD overlap. Patients with postprandial distress syndrome have a higher risk of coexisting IBS, particularly constipation-dominant IBS. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/28160607/Overlap_between_irritable_bowel_syndrome_and_functional_dyspepsia_including_subtype_analyses_ L2 - https://doi.org/10.1111/jgh.13756 DB - PRIME DP - Unbound Medicine ER -