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Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review.
J Ethnopharmacol. 2017 Mar 06; 199:205-210.JE

Abstract

BACKGROUND

Traditional Chinese medicine (TCM) has contributed greatly to human health in past several thousand years. Today, the development of TCM is facing two obstacles: (i) quality control of herbal extract; and (ii) action mechanisms not known.

OBJECTIVES

Among thousands of complex TCM formulations, Danggui Buxue Tang (DBT) is the simplest one. DBT is used to treat ailments in women and contains only two herbs, Astragali Radix (Huangqi; AR) and Angelicae Sinensis Radix (Danggui; ASR). The weight ratio of AR to ASR in DBT must be 5:1, as stipulated in AD 1247. By using DBT as a model formula, we develop a strategy to reveal the complexity of a traditional TCM formula.

RESULTS

There are 3 levels of research directions: (i) the preparation of DBT and its rationale behind; (ii) the traditional theory of DBT is elucidated by chemical and biological determinations; and (iii) the action mechanisms of DBT are revealed.

CONCLUSION

Through the chemical, biological, genomic and proteomic studies, a possible direction in resolving the preparation mythologies, pharmacological and mechanistic analyses of a TCM decoction is being proposed here.

Authors+Show Affiliations

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China; HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, Guangdong, China.Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences, 95 Yong An Road, Beijing 100050, China.Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China; HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, Guangdong, China. Electronic address: botsim@ust.hk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28163116

Citation

Lin, Huang Q., et al. "Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for Menopausal Symptoms: a Review." Journal of Ethnopharmacology, vol. 199, 2017, pp. 205-210.
Lin HQ, Gong AG, Wang HY, et al. Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review. J Ethnopharmacol. 2017;199:205-210.
Lin, H. Q., Gong, A. G., Wang, H. Y., Duan, R., Dong, T. T., Zhao, K. J., & Tsim, K. W. (2017). Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review. Journal of Ethnopharmacology, 199, 205-210. https://doi.org/10.1016/j.jep.2017.01.044
Lin HQ, et al. Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for Menopausal Symptoms: a Review. J Ethnopharmacol. 2017 Mar 6;199:205-210. PubMed PMID: 28163116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review. AU - Lin,Huang Q, AU - Gong,Amy G W, AU - Wang,Huai Y, AU - Duan,Ran, AU - Dong,Tina T X, AU - Zhao,Kui J, AU - Tsim,Karl W K, Y1 - 2017/02/02/ PY - 2016/09/14/received PY - 2017/01/21/revised PY - 2017/01/21/accepted PY - 2017/2/7/pubmed PY - 2017/7/15/medline PY - 2017/2/7/entrez KW - Angelicae Sinensis Radix KW - Astragali Radix KW - Danggui Buxue Tang KW - Traditional chinese medicine SP - 205 EP - 210 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 199 N2 - BACKGROUND: Traditional Chinese medicine (TCM) has contributed greatly to human health in past several thousand years. Today, the development of TCM is facing two obstacles: (i) quality control of herbal extract; and (ii) action mechanisms not known. OBJECTIVES: Among thousands of complex TCM formulations, Danggui Buxue Tang (DBT) is the simplest one. DBT is used to treat ailments in women and contains only two herbs, Astragali Radix (Huangqi; AR) and Angelicae Sinensis Radix (Danggui; ASR). The weight ratio of AR to ASR in DBT must be 5:1, as stipulated in AD 1247. By using DBT as a model formula, we develop a strategy to reveal the complexity of a traditional TCM formula. RESULTS: There are 3 levels of research directions: (i) the preparation of DBT and its rationale behind; (ii) the traditional theory of DBT is elucidated by chemical and biological determinations; and (iii) the action mechanisms of DBT are revealed. CONCLUSION: Through the chemical, biological, genomic and proteomic studies, a possible direction in resolving the preparation mythologies, pharmacological and mechanistic analyses of a TCM decoction is being proposed here. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/28163116/Danggui_Buxue_Tang__Astragali_Radix_and_Angelicae_Sinensis_Radix__for_menopausal_symptoms:_A_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(16)30833-9 DB - PRIME DP - Unbound Medicine ER -