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Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview.
Curr Alzheimer Res. 2017; 14(11):1190-1197.CA

Abstract

BACKGROUND

Alzheimer's disease (AD) is the most common and well-studied neurodegenerative disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Prion disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the common features and molecular mechanisms suggest that pathology may be directly comparable and be implicated in disease prevention and development of highly effective therapies.

METHOD

In this review, a brief description of pathophysiology, clinical symptoms and available treatment of various NDs have been explored with special emphasis on AD. Commonalities in these fatal NDs provide support for therapeutic advancements and enhance the understanding of disease manifestation.

CONCLUSION

The studies concentrating on the commonalities in biological pathways, cellular mechanisms and genetics may provide the scope to researchers to identify few novel common target(s) for disease prevention and development of effective common drugs for multi-neurodegenerative diseases.

Authors+Show Affiliations

Department of Medical Biotechnology, Yeungnam University, Gyeongsan. Korea.Department of Medical Biotechnology, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk 712-749. Korea.Department of Biochemistry, College of Science, King Abdulaziz University, Jeddah 21589. Saudi Arabia.King Fahd Medical Research Centre, King Abdulaziz University, P.O. Box 80216, Jeddah 21589. Saudi Arabia.Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224. United States.Department of Medical Biotechnology, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk 712-749. Korea.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28164765

Citation

Ahmad, Khurshid, et al. "Commonalities in Biological Pathways, Genetics, and Cellular Mechanism Between Alzheimer Disease and Other Neurodegenerative Diseases: an in Silico-Updated Overview." Current Alzheimer Research, vol. 14, no. 11, 2017, pp. 1190-1197.
Ahmad K, Baig MH, Mushtaq G, et al. Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview. Curr Alzheimer Res. 2017;14(11):1190-1197.
Ahmad, K., Baig, M. H., Mushtaq, G., Kamal, M. A., Greig, N. H., & Choi, I. (2017). Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview. Current Alzheimer Research, 14(11), 1190-1197. https://doi.org/10.2174/1567205014666170203141151
Ahmad K, et al. Commonalities in Biological Pathways, Genetics, and Cellular Mechanism Between Alzheimer Disease and Other Neurodegenerative Diseases: an in Silico-Updated Overview. Curr Alzheimer Res. 2017;14(11):1190-1197. PubMed PMID: 28164765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview. AU - Ahmad,Khurshid, AU - Baig,Mohammad Hassan, AU - Mushtaq,Gohar, AU - Kamal,Mohammad Amjad, AU - Greig,Nigel H, AU - Choi,Inho, PY - 2016/11/05/received PY - 2016/12/07/revised PY - 2016/01/30/accepted PY - 2017/2/7/pubmed PY - 2018/6/5/medline PY - 2017/2/7/entrez KW - Alzheimer disease KW - Amyotrophic lateral sclerosis KW - Huntington's disease KW - Neurodegenerative diseases KW - Parkinson's disease KW - biological pathways SP - 1190 EP - 1197 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 14 IS - 11 N2 - BACKGROUND: Alzheimer's disease (AD) is the most common and well-studied neurodegenerative disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Prion disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the common features and molecular mechanisms suggest that pathology may be directly comparable and be implicated in disease prevention and development of highly effective therapies. METHOD: In this review, a brief description of pathophysiology, clinical symptoms and available treatment of various NDs have been explored with special emphasis on AD. Commonalities in these fatal NDs provide support for therapeutic advancements and enhance the understanding of disease manifestation. CONCLUSION: The studies concentrating on the commonalities in biological pathways, cellular mechanisms and genetics may provide the scope to researchers to identify few novel common target(s) for disease prevention and development of effective common drugs for multi-neurodegenerative diseases. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/28164765/Commonalities_in_Biological_Pathways_Genetics_and_Cellular_Mechanism_between_Alzheimer_Disease_and_Other_Neurodegenerative_Diseases:_An_In_Silico_Updated_Overview_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1567-2050&volume=14&issue=11&spage=1190&aulast=Ahmad DB - PRIME DP - Unbound Medicine ER -