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Cochlear potential difference between endolymph fluid and the hair cell's interior: a retold interpretation based on the Goldman equation.
Med Glas (Zenica) 2017; 14(1):8-15MG

Abstract

Reported cochlear potential values of near 150 mV are often attributed to endolymph itself, although membrane potentials result from ion fluxes across the adjacent semipermeable membranes due to concentration gradients. Since any two fluids separated by a semipermeable membrane develop potential due to differences in solute concentrations, a proposed interpretation here is that positive potential emanates from the Reissner membrane due to small influx of sodium from perilymph to endolymph. Basolateral hair cell membranes leak potassium into the interstitial fluid and this negative potential inside hair cells further augments the electric gradient of cochlear potential. Taken together as a sum, these two potentials are near the reported values of cochlear potential. This is based on reported data for cochlear fluids used for the calculation of Nernst and Goldman potentials. The reported positive potential of Reissner membrane can be explained almost entirely by the traffic of Na+ that enters endolymph through this membrane. At the apical membrane of hair cells, acoustic stimulation modulates stereocillia permeability to potassium. Potassium concentration gradients on the apical membrane are low (the calculated Nernst value is <+3 mV), suggesting that the potassium current is not caused by the local potassium concentration gradient, but an electric field between the positive sodium generated potential on the Reissner membrane and negative inside hair cells. Potassium is forced by this overall electric field to enter hair cells when stereocilia are permeable due to mechanical bending.

Authors+Show Affiliations

Department of Physiology, School of Medicine, University Osijek, Osijek; Croatia.Department of Gastroenterology, Clinic of Internal Medicine, Osijek University Hospital Centre; Osijek; Croatia.Department for Tumors of Digestive Organs, Clinic of Oncology, Zagreb University Hospital Center, Zagreb; Croatia.Department of Maxillofacial Surgery, Osijek University Hospital Center, Osijek; Croatia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28165435

Citation

Kurbel, Sven, et al. "Cochlear Potential Difference Between Endolymph Fluid and the Hair Cell's Interior: a Retold Interpretation Based On the Goldman Equation." Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, vol. 14, no. 1, 2017, pp. 8-15.
Kurbel S, Borzan V, Golem H, et al. Cochlear potential difference between endolymph fluid and the hair cell's interior: a retold interpretation based on the Goldman equation. Med Glas (Zenica). 2017;14(1):8-15.
Kurbel, S., Borzan, V., Golem, H., & Dinjar, K. (2017). Cochlear potential difference between endolymph fluid and the hair cell's interior: a retold interpretation based on the Goldman equation. Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 14(1), pp. 8-15. doi:10.17392/868-16.
Kurbel S, et al. Cochlear Potential Difference Between Endolymph Fluid and the Hair Cell's Interior: a Retold Interpretation Based On the Goldman Equation. Med Glas (Zenica). 2017 Feb 1;14(1):8-15. PubMed PMID: 28165435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cochlear potential difference between endolymph fluid and the hair cell's interior: a retold interpretation based on the Goldman equation. AU - Kurbel,Sven, AU - Borzan,Vladimir, AU - Golem,Hilda, AU - Dinjar,Kristijan, PY - 2016/07/18/received PY - 2016/08/03/revised PY - 2016/11/22/accepted PY - 2017/2/7/entrez PY - 2017/2/7/pubmed PY - 2017/6/7/medline KW - ion traffic KW - labyrinth KW - membrane permeability KW - membrane potential SP - 8 EP - 15 JF - Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina JO - Med Glas (Zenica) VL - 14 IS - 1 N2 - Reported cochlear potential values of near 150 mV are often attributed to endolymph itself, although membrane potentials result from ion fluxes across the adjacent semipermeable membranes due to concentration gradients. Since any two fluids separated by a semipermeable membrane develop potential due to differences in solute concentrations, a proposed interpretation here is that positive potential emanates from the Reissner membrane due to small influx of sodium from perilymph to endolymph. Basolateral hair cell membranes leak potassium into the interstitial fluid and this negative potential inside hair cells further augments the electric gradient of cochlear potential. Taken together as a sum, these two potentials are near the reported values of cochlear potential. This is based on reported data for cochlear fluids used for the calculation of Nernst and Goldman potentials. The reported positive potential of Reissner membrane can be explained almost entirely by the traffic of Na+ that enters endolymph through this membrane. At the apical membrane of hair cells, acoustic stimulation modulates stereocillia permeability to potassium. Potassium concentration gradients on the apical membrane are low (the calculated Nernst value is <+3 mV), suggesting that the potassium current is not caused by the local potassium concentration gradient, but an electric field between the positive sodium generated potential on the Reissner membrane and negative inside hair cells. Potassium is forced by this overall electric field to enter hair cells when stereocilia are permeable due to mechanical bending. SN - 1840-2445 UR - https://www.unboundmedicine.com/medline/citation/28165435/Cochlear_potential_difference_between_endolymph_fluid_and_the_hair_cell's_interior:_a_retold_interpretation_based_on_the_Goldman_equation L2 - https://dx.doi.org/10.17392/868-16 DB - PRIME DP - Unbound Medicine ER -