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Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) root extract exhibits anti-nociceptive and antipyretic activities in murine models.
J Ethnopharmacol. 2017 Mar 06; 199:183-193.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use.

AIM OF STUDY

The present study evaluated the anti-nociceptive and antipyretic properties of the hydroethanolic extract of the roots of Albizia zygia in animal models.

MATERIALS AND METHODS

The analgesic effects were investigated in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (tail-immersion test) and mechanical (carrageenan-induced hyperalgesia) pain models. Possible mechanisms of anti-nociception were also assessed with antagonists in the formalin test. The anti-pyretic effect was evaluated using the baker yeast-induced pyrexia model in young rats.

RESULTS

The extract (30-300mg/kg, p.o.) and positive controls, diclofenac (3-30mg/kg, i.p.) and morphine (1-10mg/kg, i.p.), significantly (at least P<0.01) attenuated acetic acid-induced visceral pain, formalin- induced paw pain (both neurogenic and inflammatory), thermal pain as well as carrageenan-induced mechanical hyperalgesia in animals. The anti-nociceptive effect of the extract was reversed (at least P<0.05) by the pre-emptive administration of naloxone and atropine; the administration of theophylline, however, exhibited no significant (P>0.05) inhibition of anti-nociception. The extract (30-300mg/kg, p.o) and paracetamol (15-150mg/kg, p.o.) both reversed yeast-induced pyrexia in rats with ED50 values of 48.59±2.59 and 26.19±1.33mg/kg respectively.

CONCLUSION

The findings indicate that the extract possesses significant anti-nociceptive and antipyretic effects which justify its traditional use in the management of pain and fever. Also, anti-nociceptive effect of the extract involves opioidergic and muscarinic cholinergic mechanisms.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address: wkm_abotsi@yahoo.com.Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address: babewhyte@gmail.com.Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address: ebgyasi.pharm@knust.edu.gh.Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address: ewoode.pharm@knust.edu.gh.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28167290

Citation

Abotsi, Wonder Kofi Mensah, et al. "Albizia Zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) Root Extract Exhibits Anti-nociceptive and Antipyretic Activities in Murine Models." Journal of Ethnopharmacology, vol. 199, 2017, pp. 183-193.
Abotsi WK, Lamptey SB, Boakye-Gyasi E, et al. Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) root extract exhibits anti-nociceptive and antipyretic activities in murine models. J Ethnopharmacol. 2017;199:183-193.
Abotsi, W. K., Lamptey, S. B., Boakye-Gyasi, E., & Woode, E. (2017). Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) root extract exhibits anti-nociceptive and antipyretic activities in murine models. Journal of Ethnopharmacology, 199, 183-193. https://doi.org/10.1016/j.jep.2017.02.007
Abotsi WK, et al. Albizia Zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) Root Extract Exhibits Anti-nociceptive and Antipyretic Activities in Murine Models. J Ethnopharmacol. 2017 Mar 6;199:183-193. PubMed PMID: 28167290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) root extract exhibits anti-nociceptive and antipyretic activities in murine models. AU - Abotsi,Wonder Kofi Mensah, AU - Lamptey,Stanley Benjamin, AU - Boakye-Gyasi,Eric, AU - Woode,Eric, Y1 - 2017/02/05/ PY - 2016/07/08/received PY - 2017/01/31/revised PY - 2017/02/02/accepted PY - 2017/2/9/pubmed PY - 2017/7/15/medline PY - 2017/2/8/entrez KW - Acetic acid (PubChem CID: 176) KW - Albizia zygia KW - Atropine (PubChem CID: 174174) KW - Baker's yeast KW - Diclofenac sodium (PubChem CID: 5018304) KW - Formalin KW - Morphine hydrochloride (PubChem CID: 5464110) KW - Naloxone (PubChem CID: 5464092) KW - Opioidergic KW - Pain KW - Paracetamol (PubChem CID: 1983) KW - Pyrexia KW - Theophylline (PubChem CID: 2153) KW - carrageenan salt (PubChem CID: 6850766) SP - 183 EP - 193 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 199 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use. AIM OF STUDY: The present study evaluated the anti-nociceptive and antipyretic properties of the hydroethanolic extract of the roots of Albizia zygia in animal models. MATERIALS AND METHODS: The analgesic effects were investigated in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (tail-immersion test) and mechanical (carrageenan-induced hyperalgesia) pain models. Possible mechanisms of anti-nociception were also assessed with antagonists in the formalin test. The anti-pyretic effect was evaluated using the baker yeast-induced pyrexia model in young rats. RESULTS: The extract (30-300mg/kg, p.o.) and positive controls, diclofenac (3-30mg/kg, i.p.) and morphine (1-10mg/kg, i.p.), significantly (at least P<0.01) attenuated acetic acid-induced visceral pain, formalin- induced paw pain (both neurogenic and inflammatory), thermal pain as well as carrageenan-induced mechanical hyperalgesia in animals. The anti-nociceptive effect of the extract was reversed (at least P<0.05) by the pre-emptive administration of naloxone and atropine; the administration of theophylline, however, exhibited no significant (P>0.05) inhibition of anti-nociception. The extract (30-300mg/kg, p.o) and paracetamol (15-150mg/kg, p.o.) both reversed yeast-induced pyrexia in rats with ED50 values of 48.59±2.59 and 26.19±1.33mg/kg respectively. CONCLUSION: The findings indicate that the extract possesses significant anti-nociceptive and antipyretic effects which justify its traditional use in the management of pain and fever. Also, anti-nociceptive effect of the extract involves opioidergic and muscarinic cholinergic mechanisms. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/28167290/Albizia_zygia__DC___J_F__Macbr___Leguminosae_Mimosoideae__root_extract_exhibits_anti_nociceptive_and_antipyretic_activities_in_murine_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(17)30448-8 DB - PRIME DP - Unbound Medicine ER -