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Extinction during reconsolidation eliminates recovery of fear conditioned to fear-irrelevant and fear-relevant stimuli.
Behav Res Ther. 2017 05; 92:1-10.BR

Abstract

Extant literature suggests that extinction training delivered during the memory reconsolidation period is superior to traditional extinction training in the reduction of fear recovery, as it targets the original fear memory trace. At present it is debated whether different types of fear memories are differentially sensitive to behavioral manipulations of reconsolidation. Here, we examined post-reconsolidation recovery of fear as a function of conditioned stimulus (CS) fear-relevance, using the unconditioned stimulus (US) to reactivate and destabilize conditioned fear memories. Participants (N = 56; 25 male; M = 24.39 years, SD = 7.71) in the US-reactivation and control group underwent differential fear conditioning to fear-relevant (spiders/snakes) and fear-irrelevant (geometric shapes) CSs on Day 1. On Day 2, participants received either reminded (US-reactivation) or non-reminded extinction training. Tests of fear recovery, conducted 24 h later, revealed recovery of differential electrodermal responding to both classes of CSs in the control group, but not in the US-reactivation group. These findings indicate that the US reactivation-extinction procedure eliminated recovery of extinguished responding not only to fear-irrelevant, but also to fear-relevant CSs. Contrasting previous reports, our findings show that post-reconsolidation recovery of conditioned responding is not a function of CS fear-relevance and that persistent reduction of fear, conditioned to fear-relevant CSs, can be achieved through behavioral manipulations of reconsolidation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Thompson A
School of Psychology and Speech Pathology, Curtin University, Australia. Electronic address: alina.thompson@curtin.edu.au.
Lipp OV
School of Psychology and Speech Pathology, Curtin University, Australia; ARC-SRI: Science of Learning Research Centre, Australia.

MeSH

AdultConditioning, ClassicalExtinction, PsychologicalFearFemaleGalvanic Skin ResponseHumansMaleMemoryYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28171767

Citation

Thompson, Alina, and Ottmar V. Lipp. "Extinction During Reconsolidation Eliminates Recovery of Fear Conditioned to Fear-irrelevant and Fear-relevant Stimuli." Behaviour Research and Therapy, vol. 92, 2017, pp. 1-10.
Thompson A, Lipp OV. Extinction during reconsolidation eliminates recovery of fear conditioned to fear-irrelevant and fear-relevant stimuli. Behav Res Ther. 2017;92:1-10.
Thompson, A., & Lipp, O. V. (2017). Extinction during reconsolidation eliminates recovery of fear conditioned to fear-irrelevant and fear-relevant stimuli. Behaviour Research and Therapy, 92, 1-10. https://doi.org/10.1016/j.brat.2017.01.017
Thompson A, Lipp OV. Extinction During Reconsolidation Eliminates Recovery of Fear Conditioned to Fear-irrelevant and Fear-relevant Stimuli. Behav Res Ther. 2017;92:1-10. PubMed PMID: 28171767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extinction during reconsolidation eliminates recovery of fear conditioned to fear-irrelevant and fear-relevant stimuli. AU - Thompson,Alina, AU - Lipp,Ottmar V, Y1 - 2017/02/02/ PY - 2016/08/24/received PY - 2017/01/25/revised PY - 2017/01/30/accepted PY - 2017/2/9/pubmed PY - 2017/9/30/medline PY - 2017/2/8/entrez KW - Extinction KW - Fear-relevance KW - Prediction error KW - Reconsolidation KW - Return of fear KW - US-reactivation SP - 1 EP - 10 JF - Behaviour research and therapy JO - Behav Res Ther VL - 92 N2 - Extant literature suggests that extinction training delivered during the memory reconsolidation period is superior to traditional extinction training in the reduction of fear recovery, as it targets the original fear memory trace. At present it is debated whether different types of fear memories are differentially sensitive to behavioral manipulations of reconsolidation. Here, we examined post-reconsolidation recovery of fear as a function of conditioned stimulus (CS) fear-relevance, using the unconditioned stimulus (US) to reactivate and destabilize conditioned fear memories. Participants (N = 56; 25 male; M = 24.39 years, SD = 7.71) in the US-reactivation and control group underwent differential fear conditioning to fear-relevant (spiders/snakes) and fear-irrelevant (geometric shapes) CSs on Day 1. On Day 2, participants received either reminded (US-reactivation) or non-reminded extinction training. Tests of fear recovery, conducted 24 h later, revealed recovery of differential electrodermal responding to both classes of CSs in the control group, but not in the US-reactivation group. These findings indicate that the US reactivation-extinction procedure eliminated recovery of extinguished responding not only to fear-irrelevant, but also to fear-relevant CSs. Contrasting previous reports, our findings show that post-reconsolidation recovery of conditioned responding is not a function of CS fear-relevance and that persistent reduction of fear, conditioned to fear-relevant CSs, can be achieved through behavioral manipulations of reconsolidation. SN - 1873-622X UR - https://www.unboundmedicine.com/medline/citation/28171767/Extinction_during_reconsolidation_eliminates_recovery_of_fear_conditioned_to_fear_irrelevant_and_fear_relevant_stimuli_ DB - PRIME DP - Unbound Medicine ER -