Tags

Type your tag names separated by a space and hit enter

Insoluble Dietary Fiber from Pear Pomace Can Prevent High-Fat Diet-Induced Obesity in Rats Mainly by Improving the Structure of the Gut Microbiota.
J Microbiol Biotechnol 2017; 27(4):856-867JM

Abstract

Supplement of dietary fibers (DF) is regarded as one of the most effective way to prevent and relieve chronic diseases caused by long-term intake of a high-fat diet in the current society. The health benefits of soluble dietary fibers (SDF) have been widely researched and applied, whereas the insoluble dietary fibers (IDF), which represent a higher proportion in plant food, were mistakenly thought to have effects only in fecal bulking. In this article, we proved the anti-obesity and glucose homeostasis improvement effects of IDF from pear pomace at first, and then the mechanisms responsible for these effects were analyzed. The preliminary study by real-time PCR and ELISA showed that this kind of IDF caused more changes in the gut microbiota compared with in satiety hormone or in hepatic metabolism. Further analysis of the gut microbiota by high-throughput amplicon sequencing showed IDF from pear pomace obviously improved the structure of the gut microbiota. Specifically, it promoted the growth of Bacteroidetes and inhibited the growth of Firmicutes. These results are coincident with previous hypothesis that the ratio of Bacteroidetes/Firmicutes is negatively related with obesity. In conclusion, our results demonstrated IDF from pear pomace could prevent high-fat diet-induced obesity in rats mainly by improving the structure of the gut microbiota.

Authors+Show Affiliations

College of Horticulture, Agricultural University of Hebei, Baoding 071001, P.R. China. College of Agriculture, Hebei University of Engineering, Handan 056038, P.R. China.Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China.Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China.College of Food Science and Technology, Agricultural University of Hebei, Baoding 071001, P.R. China.Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China.Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China.College of Horticulture, Agricultural University of Hebei, Baoding 071001, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28173692

Citation

Chang, Shimin, et al. "Insoluble Dietary Fiber From Pear Pomace Can Prevent High-Fat Diet-Induced Obesity in Rats Mainly By Improving the Structure of the Gut Microbiota." Journal of Microbiology and Biotechnology, vol. 27, no. 4, 2017, pp. 856-867.
Chang S, Cui X, Guo M, et al. Insoluble Dietary Fiber from Pear Pomace Can Prevent High-Fat Diet-Induced Obesity in Rats Mainly by Improving the Structure of the Gut Microbiota. J Microbiol Biotechnol. 2017;27(4):856-867.
Chang, S., Cui, X., Guo, M., Tian, Y., Xu, W., Huang, K., & Zhang, Y. (2017). Insoluble Dietary Fiber from Pear Pomace Can Prevent High-Fat Diet-Induced Obesity in Rats Mainly by Improving the Structure of the Gut Microbiota. Journal of Microbiology and Biotechnology, 27(4), pp. 856-867. doi:10.4014/jmb.1610.10058.
Chang S, et al. Insoluble Dietary Fiber From Pear Pomace Can Prevent High-Fat Diet-Induced Obesity in Rats Mainly By Improving the Structure of the Gut Microbiota. J Microbiol Biotechnol. 2017 Apr 28;27(4):856-867. PubMed PMID: 28173692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insoluble Dietary Fiber from Pear Pomace Can Prevent High-Fat Diet-Induced Obesity in Rats Mainly by Improving the Structure of the Gut Microbiota. AU - Chang,Shimin, AU - Cui,Xingtian, AU - Guo,Mingzhang, AU - Tian,Yiling, AU - Xu,Wentao, AU - Huang,Kunlun, AU - Zhang,Yuxing, PY - 2017/2/9/pubmed PY - 2017/10/7/medline PY - 2017/2/9/entrez KW - Insoluble dietary fiber KW - amplicon sequencing KW - anti-obesity KW - gut microbiota SP - 856 EP - 867 JF - Journal of microbiology and biotechnology JO - J. Microbiol. Biotechnol. VL - 27 IS - 4 N2 - Supplement of dietary fibers (DF) is regarded as one of the most effective way to prevent and relieve chronic diseases caused by long-term intake of a high-fat diet in the current society. The health benefits of soluble dietary fibers (SDF) have been widely researched and applied, whereas the insoluble dietary fibers (IDF), which represent a higher proportion in plant food, were mistakenly thought to have effects only in fecal bulking. In this article, we proved the anti-obesity and glucose homeostasis improvement effects of IDF from pear pomace at first, and then the mechanisms responsible for these effects were analyzed. The preliminary study by real-time PCR and ELISA showed that this kind of IDF caused more changes in the gut microbiota compared with in satiety hormone or in hepatic metabolism. Further analysis of the gut microbiota by high-throughput amplicon sequencing showed IDF from pear pomace obviously improved the structure of the gut microbiota. Specifically, it promoted the growth of Bacteroidetes and inhibited the growth of Firmicutes. These results are coincident with previous hypothesis that the ratio of Bacteroidetes/Firmicutes is negatively related with obesity. In conclusion, our results demonstrated IDF from pear pomace could prevent high-fat diet-induced obesity in rats mainly by improving the structure of the gut microbiota. SN - 1738-8872 UR - https://www.unboundmedicine.com/medline/citation/28173692/Insoluble_Dietary_Fiber_from_Pear_Pomace_Can_Prevent_High_Fat_Diet_Induced_Obesity_in_Rats_Mainly_by_Improving_the_Structure_of_the_Gut_Microbiota_ L2 - http://www.jmb.or.kr/journal/viewJournal.html?doi=10.4014/jmb.1610.10058 DB - PRIME DP - Unbound Medicine ER -