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Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease.
Appl Physiol Nutr Metab. 2017 Mar; 42(3):295-301.AP

Abstract

Possible association between Helicobacter pylori infection (HPI) and nonalcoholic fatty liver disease (NAFLD) has been proposed by several studies with inconsistent conclusions. Here, we studied the association between HPI and NAFLD at 3 levels: (i) genetic level; (ii) small molecular level; and (iii) clinical level. Relation data between diseases, genes, and small molecules were acquired from Pathway Studio ResNet Mammalian database. Clinical data were acquired from 2263 elderly South Chinese subjects, including 603 NAFLD patients and 1660 subjects without NAFLD. Results showed that HPI and NAFLD present significantly shared genetic bases (95 genes, p value = 2.5E-72), demonstrating multiple common genetic pathways (enrichment p value ≤ 4.38E-20 for the top 10 pathways). Genetic network analysis suggested that mutual regulation may exist between HPI and NAFLD through 21 out of 95 genes. Furthermore, 85 out of the 95 genes manifested strong interaction with 12 small molecules/drugs that demonstrate effectiveness in treating both diseases. Clinical results showed that HPI rate in the NAFLD group was significantly higher than that in the group without NAFLD (51.9% vs. 43.6%; p value = 4.9E-4). Multivariate logistic regression results supported the observations and suggested that HPI served as a risk factor for NAFLD in the experiment data studied (odds ratio: 1.387, p value = 0.018). Results from this study support the hypothesis that complex biological association may exist between HPI and NAFLD, which partially explains the significant clinical co-incidence in the elderly population of south China.

Authors+Show Affiliations

a Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China. b Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, 315207, China.c Department of Endocrinology, the Affiliated Hospital of Medical College of Ningbo University, Ningbo, 315020, China.d Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD 20852, USA.b Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, 315207, China.b Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, 315207, China.e Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28177748

Citation

Chen, Chang-Xi, et al. "Possible Association Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 42, no. 3, 2017, pp. 295-301.
Chen CX, Mao YS, Foster P, et al. Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease. Appl Physiol Nutr Metab. 2017;42(3):295-301.
Chen, C. X., Mao, Y. S., Foster, P., Zhu, Z. W., Du, J., & Guo, C. Y. (2017). Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 42(3), 295-301. https://doi.org/10.1139/apnm-2016-0499
Chen CX, et al. Possible Association Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease. Appl Physiol Nutr Metab. 2017;42(3):295-301. PubMed PMID: 28177748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease. AU - Chen,Chang-Xi, AU - Mao,Yu-Shan, AU - Foster,Parker, AU - Zhu,Zhong-Wei, AU - Du,Juan, AU - Guo,Chuan-Yong, Y1 - 2016/11/18/ PY - 2017/2/9/pubmed PY - 2017/3/30/medline PY - 2017/2/9/entrez KW - Helicobacter pylori infection KW - ResNet Database KW - analyse de connectivité du réseau KW - analyse d’enrichissement de voies KW - base de données ResNet KW - infection par Helicobacter pylori KW - network connectivity analysis KW - nonalcoholic fatty liver disease KW - pathway enrichment analysis KW - stéatose hépatique non alcoolique SP - 295 EP - 301 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 42 IS - 3 N2 - Possible association between Helicobacter pylori infection (HPI) and nonalcoholic fatty liver disease (NAFLD) has been proposed by several studies with inconsistent conclusions. Here, we studied the association between HPI and NAFLD at 3 levels: (i) genetic level; (ii) small molecular level; and (iii) clinical level. Relation data between diseases, genes, and small molecules were acquired from Pathway Studio ResNet Mammalian database. Clinical data were acquired from 2263 elderly South Chinese subjects, including 603 NAFLD patients and 1660 subjects without NAFLD. Results showed that HPI and NAFLD present significantly shared genetic bases (95 genes, p value = 2.5E-72), demonstrating multiple common genetic pathways (enrichment p value ≤ 4.38E-20 for the top 10 pathways). Genetic network analysis suggested that mutual regulation may exist between HPI and NAFLD through 21 out of 95 genes. Furthermore, 85 out of the 95 genes manifested strong interaction with 12 small molecules/drugs that demonstrate effectiveness in treating both diseases. Clinical results showed that HPI rate in the NAFLD group was significantly higher than that in the group without NAFLD (51.9% vs. 43.6%; p value = 4.9E-4). Multivariate logistic regression results supported the observations and suggested that HPI served as a risk factor for NAFLD in the experiment data studied (odds ratio: 1.387, p value = 0.018). Results from this study support the hypothesis that complex biological association may exist between HPI and NAFLD, which partially explains the significant clinical co-incidence in the elderly population of south China. SN - 1715-5320 UR - https://www.unboundmedicine.com/medline/citation/28177748/Possible_association_between_Helicobacter_pylori_infection_and_nonalcoholic_fatty_liver_disease_ L2 - https://cdnsciencepub.com/doi/10.1139/apnm-2016-0499?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -