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Is acne a sign of androgen excess disorder or not?
Eur J Obstet Gynecol Reprod Biol. 2017 Apr; 211:21-25.EJ

Abstract

OBJECTIVE

Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not.

STUDY DESIGN

This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne. The women were assigned as polycystic ovary syndrome (PCOS), idiopathic hirsutism (IH), idiopathic hyperandrogenemia (IHA). Women with acne associated with any of the androgen excess disorders mentioned above were named as hyperandrogenemia associated acne (HAA). Women with acne but without hirsutism and hyperandrogenemia and having ovulatory cycles were named as "isolated acne". Serum luteinizing hormone, follicle stimulating hormone, estradiol, progesterone, 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate (DHEAS), androstenedione, total testosterone and lipid levels were measured.

RESULTS

Acne score was similar between the women with isolated acne and HAA. The most common cause for acne was PCOS and only 28% of the women had isolated acne. 114 (55%) women had at least one raised serum androgen level.

CONCLUSIONS

In this study, 72% of acneic women had clinical and/or biochemical hyperandrogenemia. In contrast to the suggestion of ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group, our data indicate that the presence of androgen excess disorders should be evaluated in women presenting with acne.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, Adana, Turkey. Electronic address: gulsumaykut@yahoo.com.Department of Obstetrics and Gynecology, Erciyes University Medical School, Kayseri, Turkey.Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.Department of Dermatology, Erciyes University Medical School, Kayseri, Turkey.Department of Obstetrics and Gynecology, Erciyes University Medical School, Kayseri, Turkey.Department of Obstetrics and Gynecology, Erciyes University Medical School, Kayseri, Turkey.Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28178574

Citation

Uysal, Gulsum, et al. "Is Acne a Sign of Androgen Excess Disorder or Not?" European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 211, 2017, pp. 21-25.
Uysal G, Sahin Y, Unluhizarci K, et al. Is acne a sign of androgen excess disorder or not? Eur J Obstet Gynecol Reprod Biol. 2017;211:21-25.
Uysal, G., Sahin, Y., Unluhizarci, K., Ferahbas, A., Uludag, S. Z., Aygen, E., & Kelestimur, F. (2017). Is acne a sign of androgen excess disorder or not? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 211, 21-25. https://doi.org/10.1016/j.ejogrb.2017.01.054
Uysal G, et al. Is Acne a Sign of Androgen Excess Disorder or Not. Eur J Obstet Gynecol Reprod Biol. 2017;211:21-25. PubMed PMID: 28178574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is acne a sign of androgen excess disorder or not? AU - Uysal,Gulsum, AU - Sahin,Yılmaz, AU - Unluhizarci,Kursad, AU - Ferahbas,Ayten, AU - Uludag,Semih Zeki, AU - Aygen,Ercan, AU - Kelestimur,Fahrettin, Y1 - 2017/01/23/ PY - 2016/08/29/received PY - 2016/10/30/revised PY - 2017/01/22/accepted PY - 2017/2/9/pubmed PY - 2017/9/28/medline PY - 2017/2/9/entrez KW - Acne KW - Androgen excess disorders KW - Hirsutism KW - Hyperandrogenemia KW - Polycystic ovary syndrome SP - 21 EP - 25 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 211 N2 - OBJECTIVE: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not. STUDY DESIGN: This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne. The women were assigned as polycystic ovary syndrome (PCOS), idiopathic hirsutism (IH), idiopathic hyperandrogenemia (IHA). Women with acne associated with any of the androgen excess disorders mentioned above were named as hyperandrogenemia associated acne (HAA). Women with acne but without hirsutism and hyperandrogenemia and having ovulatory cycles were named as "isolated acne". Serum luteinizing hormone, follicle stimulating hormone, estradiol, progesterone, 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate (DHEAS), androstenedione, total testosterone and lipid levels were measured. RESULTS: Acne score was similar between the women with isolated acne and HAA. The most common cause for acne was PCOS and only 28% of the women had isolated acne. 114 (55%) women had at least one raised serum androgen level. CONCLUSIONS: In this study, 72% of acneic women had clinical and/or biochemical hyperandrogenemia. In contrast to the suggestion of ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group, our data indicate that the presence of androgen excess disorders should be evaluated in women presenting with acne. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/28178574/Is_acne_a_sign_of_androgen_excess_disorder_or_not L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(17)30062-3 DB - PRIME DP - Unbound Medicine ER -