Tags

Type your tag names separated by a space and hit enter

Pediatric-onset inflammatory bowel disease poses risk for low bone mineral density at early adulthood.
Dig Liver Dis. 2017 Jun; 49(6):639-642.DL

Abstract

BACKGROUND

Inflammatory bowel disease (IBD) is known to pose a risk for low bone mineral density (BMD) in children and adults. We aimed to evaluate the impact of pediatric-onset IBD on BMD in adulthood.

METHODS

Records of pediatric-IBD patients were retrospectively reviewed for documentation of dual-energy X-ray absorptiometry (DXA) scans in adulthood. BMD was expressed as z-score.

RESULTS

Sixty one patients were included. Mean (±SD) age at diagnosis was 14.7 (±2.4) years. Mean age at first DXA scan in adulthood was 23.9 years (±4.8). Median BMD z-score was -1.2 SD (IQR, -1.8 to -0.4), significantly lower than expected in normal population (p<0.001). Osteopenia (BMD z-score ≤-1 SD) was noted in 44.3% (n=27), and osteoporosis (BMD z-score ≤-2.5 SD) in 8.2% (n=5). Bone-status showed no correlation with age, disease severity, vitamin D status at diagnosis, IBD subtype or duration of disease. Positive correlation (r=0.306) was identified between low weight z-score at diagnosis and abnormal bone-status in adulthood. Among 36 patients with multiple DXA scans, there was no significant change in BMD during follow-up of 2.4 years.

CONCLUSIONS

Osteopenia and osteoporosis are frequent in adult IBD patients with pediatric-onset disease and correlates with low weight z-score at diagnosis.

Authors+Show Affiliations

Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: anatguz@gmail.com.Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Petah-Tikva, Israel.Institute of Endocrinology, Diabetes and Metabolism, Rabin Medical Center, Beilinson Campus, Petach-Tikva, Israel.Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Institute of Endocrinology, Diabetes and Metabolism, Rabin Medical Center, Beilinson Campus, Petach-Tikva, Israel.Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28179094

Citation

Guz-Mark, Anat, et al. "Pediatric-onset Inflammatory Bowel Disease Poses Risk for Low Bone Mineral Density at Early Adulthood." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 49, no. 6, 2017, pp. 639-642.
Guz-Mark A, Rinawi F, Egotubov O, et al. Pediatric-onset inflammatory bowel disease poses risk for low bone mineral density at early adulthood. Dig Liver Dis. 2017;49(6):639-642.
Guz-Mark, A., Rinawi, F., Egotubov, O., Shimon, I., Shamir, R., & Assa, A. (2017). Pediatric-onset inflammatory bowel disease poses risk for low bone mineral density at early adulthood. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 49(6), 639-642. https://doi.org/10.1016/j.dld.2017.01.151
Guz-Mark A, et al. Pediatric-onset Inflammatory Bowel Disease Poses Risk for Low Bone Mineral Density at Early Adulthood. Dig Liver Dis. 2017;49(6):639-642. PubMed PMID: 28179094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pediatric-onset inflammatory bowel disease poses risk for low bone mineral density at early adulthood. AU - Guz-Mark,Anat, AU - Rinawi,Firas, AU - Egotubov,Oxana, AU - Shimon,Ilan, AU - Shamir,Raanan, AU - Assa,Amit, Y1 - 2017/01/20/ PY - 2016/09/15/received PY - 2016/12/17/revised PY - 2017/01/09/accepted PY - 2017/2/10/pubmed PY - 2018/4/21/medline PY - 2017/2/10/entrez KW - Bone density KW - Crohn’s disease KW - Dual-energy X-ray absorptiometry KW - Ulcerative Colitis SP - 639 EP - 642 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 49 IS - 6 N2 - BACKGROUND: Inflammatory bowel disease (IBD) is known to pose a risk for low bone mineral density (BMD) in children and adults. We aimed to evaluate the impact of pediatric-onset IBD on BMD in adulthood. METHODS: Records of pediatric-IBD patients were retrospectively reviewed for documentation of dual-energy X-ray absorptiometry (DXA) scans in adulthood. BMD was expressed as z-score. RESULTS: Sixty one patients were included. Mean (±SD) age at diagnosis was 14.7 (±2.4) years. Mean age at first DXA scan in adulthood was 23.9 years (±4.8). Median BMD z-score was -1.2 SD (IQR, -1.8 to -0.4), significantly lower than expected in normal population (p<0.001). Osteopenia (BMD z-score ≤-1 SD) was noted in 44.3% (n=27), and osteoporosis (BMD z-score ≤-2.5 SD) in 8.2% (n=5). Bone-status showed no correlation with age, disease severity, vitamin D status at diagnosis, IBD subtype or duration of disease. Positive correlation (r=0.306) was identified between low weight z-score at diagnosis and abnormal bone-status in adulthood. Among 36 patients with multiple DXA scans, there was no significant change in BMD during follow-up of 2.4 years. CONCLUSIONS: Osteopenia and osteoporosis are frequent in adult IBD patients with pediatric-onset disease and correlates with low weight z-score at diagnosis. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/28179094/Pediatric_onset_inflammatory_bowel_disease_poses_risk_for_low_bone_mineral_density_at_early_adulthood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(17)30155-X DB - PRIME DP - Unbound Medicine ER -