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Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015.
PLoS Negl Trop Dis 2017; 11(2):e0005228PN

Abstract

BACKGROUND

Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection.

METHODOLOGY/PRINCIPAL FINDINGS

Data on leptospirosis infection in humans and livestock (Buffaloes, Cattle, and Pigs) species during 2010 to 2015 were analyzed. Serum samples were examined using Microscopic Agglutination Test (MAT) to identify antibodies against Leptospira serovars using a cut-off titer ≥ 1:100. The seroprevalence was 23.7% in humans, 24.8% in buffaloes, 28.1% in cattle, and 11.3% in pigs. Region specific prevalence among humans and livestock was found in a wide range. The most predominant serovars were Shermani, followed by Bratislava, Panama, and Sejroe in human, Shermani, Ranarum, and Tarassovi in buffaloes, and Shermani and Ranarum in cattle and pigs. Equally highest MAT titers against multiple serovars per one sample were found mainly in buffaloes and cattle showing equally titers against Ranarum and Shermani. The correlations of distribution of serovars across Thailand's regions were found to be similar in pattern for cattle but not for buffaloes. In humans, the serovar distribution in the south differed from other regions. By logistic regression, the results indicated that livestock is more susceptible to infection by serovar Shermani when compared to humans.

CONCLUSIONS/SIGNIFICANCE

This study gives a detailed picture of the predominance of Leptospira serovars in relation to region, humans and typical livestock. The broad spatial distribution of seroprevalence was analyzed across and within species as well as regions in Thailand. Our finding may guide public health policy makers to implement appropriate control measures and help to reduce the impact of leptospirosis in Thailand.

Authors+Show Affiliations

Department of Physics, Faculty of Science, Naresuan University, Phitsanulok, Thailand.Biomathematics & Epidemiology, EPHP-TIMC Lab, UMR 5525 CNRS Univ Grenoble Alpes, VetAgro Sup, 69280 Marcy l'Etoile, France.Department of Clinical Sciences and Public Health, and the Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand.National Institute of Animal Health, Department of Livestock Development, Bangkok, Thailand.National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nontaburi, Thailand.Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok, Thailand. Centre of Excellence in Mathematics, CHE, 328, Si Ayutthaya Road, Bangkok, Thailand.Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok, Thailand. Centre of Excellence in Mathematics, CHE, 328, Si Ayutthaya Road, Bangkok, Thailand.Department of Clinical Science and Public Health, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand.UMR EPIA, INRA, VetAgro Sup, Univ Lyon, 69280 Marcy l'Etoile, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28182662

Citation

Chadsuthi, Sudarat, et al. "Investigation On Predominant Leptospira Serovars and Its Distribution in Humans and Livestock in Thailand, 2010-2015." PLoS Neglected Tropical Diseases, vol. 11, no. 2, 2017, pp. e0005228.
Chadsuthi S, Bicout DJ, Wiratsudakul A, et al. Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. PLoS Negl Trop Dis. 2017;11(2):e0005228.
Chadsuthi, S., Bicout, D. J., Wiratsudakul, A., Suwancharoen, D., Petkanchanapong, W., Modchang, C., ... Chalvet-Monfray, K. (2017). Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. PLoS Neglected Tropical Diseases, 11(2), pp. e0005228. doi:10.1371/journal.pntd.0005228.
Chadsuthi S, et al. Investigation On Predominant Leptospira Serovars and Its Distribution in Humans and Livestock in Thailand, 2010-2015. PLoS Negl Trop Dis. 2017;11(2):e0005228. PubMed PMID: 28182662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. AU - Chadsuthi,Sudarat, AU - Bicout,Dominique J, AU - Wiratsudakul,Anuwat, AU - Suwancharoen,Duangjai, AU - Petkanchanapong,Wimol, AU - Modchang,Charin, AU - Triampo,Wannapong, AU - Ratanakorn,Parntep, AU - Chalvet-Monfray,Karine, Y1 - 2017/02/09/ PY - 2016/07/13/received PY - 2016/12/03/accepted PY - 2017/02/24/revised PY - 2017/2/10/pubmed PY - 2017/6/24/medline PY - 2017/2/10/entrez SP - e0005228 EP - e0005228 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 11 IS - 2 N2 - BACKGROUND: Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDINGS: Data on leptospirosis infection in humans and livestock (Buffaloes, Cattle, and Pigs) species during 2010 to 2015 were analyzed. Serum samples were examined using Microscopic Agglutination Test (MAT) to identify antibodies against Leptospira serovars using a cut-off titer ≥ 1:100. The seroprevalence was 23.7% in humans, 24.8% in buffaloes, 28.1% in cattle, and 11.3% in pigs. Region specific prevalence among humans and livestock was found in a wide range. The most predominant serovars were Shermani, followed by Bratislava, Panama, and Sejroe in human, Shermani, Ranarum, and Tarassovi in buffaloes, and Shermani and Ranarum in cattle and pigs. Equally highest MAT titers against multiple serovars per one sample were found mainly in buffaloes and cattle showing equally titers against Ranarum and Shermani. The correlations of distribution of serovars across Thailand's regions were found to be similar in pattern for cattle but not for buffaloes. In humans, the serovar distribution in the south differed from other regions. By logistic regression, the results indicated that livestock is more susceptible to infection by serovar Shermani when compared to humans. CONCLUSIONS/SIGNIFICANCE: This study gives a detailed picture of the predominance of Leptospira serovars in relation to region, humans and typical livestock. The broad spatial distribution of seroprevalence was analyzed across and within species as well as regions in Thailand. Our finding may guide public health policy makers to implement appropriate control measures and help to reduce the impact of leptospirosis in Thailand. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/28182662/Investigation_on_predominant_Leptospira_serovars_and_its_distribution_in_humans_and_livestock_in_Thailand_2010_2015_ L2 - http://dx.plos.org/10.1371/journal.pntd.0005228 DB - PRIME DP - Unbound Medicine ER -