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Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles.
Metabolism 2017; 68:11-19M

Abstract

BACKGROUND AND AIMS

Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated.

METHODS

In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA.

RESULTS

The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (-8%, p=0.013) and LDL cholesterol (LDL-C) level (-8%, p=0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency.

CONCLUSION

Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles.

Authors+Show Affiliations

Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: cintia.dias@uon.edu.au.Metabolomics Platform, Rovira i Virgili University, IISPV, Avinguda Països Catalans 26, 43007 Tarragona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, 28029, Madrid, Spain; Biosfer Teslab, Plaça Prim 10, 2on 5a, 43201 Reus, Spain. Electronic address: namigo@biosferteslab.com.Centre for Asthma and Respiratory Disease, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: lisa.wood@newcastle.edu.au.Biosfer Teslab, Plaça Prim 10, 2on 5a, 43201 Reus, Spain. Electronic address: rmallol@biosferteslab.com.Metabolomics Platform, Rovira i Virgili University, IISPV, Avinguda Països Catalans 26, 43007 Tarragona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, 28029, Madrid, Spain. Electronic address: xavier.correig@urv.cat.Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: manohar.garg@newcastle.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28183443

Citation

Dias, Cintia B., et al. "Improvement of the Omega 3 Index of Healthy Subjects Does Not Alter the Effects of Dietary Saturated Fats or n-6PUFA On LDL Profiles." Metabolism: Clinical and Experimental, vol. 68, 2017, pp. 11-19.
Dias CB, Amigó N, Wood LG, et al. Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles. Metab Clin Exp. 2017;68:11-19.
Dias, C. B., Amigó, N., Wood, L. G., Mallol, R., Correig, X., & Garg, M. L. (2017). Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles. Metabolism: Clinical and Experimental, 68, pp. 11-19. doi:10.1016/j.metabol.2016.11.014.
Dias CB, et al. Improvement of the Omega 3 Index of Healthy Subjects Does Not Alter the Effects of Dietary Saturated Fats or n-6PUFA On LDL Profiles. Metab Clin Exp. 2017;68:11-19. PubMed PMID: 28183443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles. AU - Dias,Cintia B, AU - Amigó,Núria, AU - Wood,Lisa G, AU - Mallol,Roger, AU - Correig,Xavier, AU - Garg,Manohar L, Y1 - 2016/12/01/ PY - 2016/08/28/received PY - 2016/11/17/revised PY - 2016/11/25/accepted PY - 2017/2/11/entrez PY - 2017/2/12/pubmed PY - 2017/5/24/medline KW - Lipids KW - Lipoprotein profiles KW - Nuclear magnetic resonance spectroscopy KW - Omega-3 polyunsaturated fatty acids KW - Saturated fatty acids SP - 11 EP - 19 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 68 N2 - BACKGROUND AND AIMS: Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated. METHODS: In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA. RESULTS: The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (-8%, p=0.013) and LDL cholesterol (LDL-C) level (-8%, p=0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency. CONCLUSION: Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/28183443/Improvement_of_the_omega_3_index_of_healthy_subjects_does_not_alter_the_effects_of_dietary_saturated_fats_or_n_6PUFA_on_LDL_profiles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(16)30172-X DB - PRIME DP - Unbound Medicine ER -