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A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel.
Mater Sci Eng C Mater Biol Appl. 2017 Apr 01; 73:456-464.MS

Abstract

Lack of antibacterial activity, deficient water vapor and oxygen permeability, and insufficient mechanical properties are disadvantages of existing wound dressings. Hydrogels could absorb wound exudates due to their strong swelling ratio and give a cooling sensation and a wet environment. To overcome these shortcomings, flexible nanocomposite hydrogel films was prepared through combination of zinc oxide impregnated mesoporous silica (ZnO-MCM-41) as a nano drug carrier with carboxymethyl cellulose (CMC) hydrogel. Citric acid was used as cross linker to avoid the cytotoxicity of conventional cross linkers. The prepared nanocomposite hydrogel was characterized using X-ray diffractometry (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Zeta potential and UV-vis spectroscopy. Results of swelling and erosion tests showed CMC/ZnO nanocomposite hydrogel disintegrated during the first hours of the test. Using MCM-41 as a substrate for ZnO nanoparticles solved this problem and the CMC/ZnO-MCM-41 showed a great improvement in tensile strength (12%), swelling (100%), erosion (53%) and gas permeability (500%) properties. Drug delivery and antibacterial properties of the nanocomposite hydrogel films studied using tetracycline (TC) as a broad spectrum antibiotic and showed a sustained TC release. This could efficiently decrease bandage exchange. Cytocompatibility of the nanocomposite hydrogel films has been analyzed in adipose tissue-derived stem cells (ADSCs) and results showed cytocompatibility of CMC/ZnO-MCM-41. Based on these results the prepared CMC nanocomposite hydrogel containing ZnO impregnated MCM-41, could serve as a kind of promising wound dressing with sustained drug delivery properties.

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Authors+Show Affiliations

Rakhshaei R
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
Namazi H
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.

MeSH

Adipose TissueAnimalsAnti-Bacterial AgentsBandagesBiocompatible MaterialsCarboxymethylcellulose SodiumCell SurvivalDrug LiberationEscherichia coliHydrogel, Polyethylene Glycol DimethacrylateMicrobial Sensitivity TestsNanocompositesPermeabilitySilicon DioxideStatic ElectricitySteamStem CellsTensile StrengthTetracyclineWound HealingX-Ray DiffractionZinc Oxide

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28183632

Citation

Rakhshaei, Rasul, and Hassan Namazi. "A Potential Bioactive Wound Dressing Based On Carboxymethyl cellulose/ZnO Impregnated MCM-41 Nanocomposite Hydrogel." Materials Science & Engineering. C, Materials for Biological Applications, vol. 73, 2017, pp. 456-464.
Rakhshaei R, Namazi H. A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel. Mater Sci Eng C Mater Biol Appl. 2017;73:456-464.
Rakhshaei, R., & Namazi, H. (2017). A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel. Materials Science & Engineering. C, Materials for Biological Applications, 73, 456-464. https://doi.org/10.1016/j.msec.2016.12.097
Rakhshaei R, Namazi H. A Potential Bioactive Wound Dressing Based On Carboxymethyl cellulose/ZnO Impregnated MCM-41 Nanocomposite Hydrogel. Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:456-464. PubMed PMID: 28183632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel. AU - Rakhshaei,Rasul, AU - Namazi,Hassan, Y1 - 2016/12/21/ PY - 2016/08/10/received PY - 2016/10/12/revised PY - 2016/12/20/accepted PY - 2017/2/11/entrez PY - 2017/2/12/pubmed PY - 2017/6/7/medline KW - Drug delivery KW - Hydrogel nanocomposite KW - Mesoporous silica KW - Wound dressing KW - Zinc oxide SP - 456 EP - 464 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 73 N2 - Lack of antibacterial activity, deficient water vapor and oxygen permeability, and insufficient mechanical properties are disadvantages of existing wound dressings. Hydrogels could absorb wound exudates due to their strong swelling ratio and give a cooling sensation and a wet environment. To overcome these shortcomings, flexible nanocomposite hydrogel films was prepared through combination of zinc oxide impregnated mesoporous silica (ZnO-MCM-41) as a nano drug carrier with carboxymethyl cellulose (CMC) hydrogel. Citric acid was used as cross linker to avoid the cytotoxicity of conventional cross linkers. The prepared nanocomposite hydrogel was characterized using X-ray diffractometry (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Zeta potential and UV-vis spectroscopy. Results of swelling and erosion tests showed CMC/ZnO nanocomposite hydrogel disintegrated during the first hours of the test. Using MCM-41 as a substrate for ZnO nanoparticles solved this problem and the CMC/ZnO-MCM-41 showed a great improvement in tensile strength (12%), swelling (100%), erosion (53%) and gas permeability (500%) properties. Drug delivery and antibacterial properties of the nanocomposite hydrogel films studied using tetracycline (TC) as a broad spectrum antibiotic and showed a sustained TC release. This could efficiently decrease bandage exchange. Cytocompatibility of the nanocomposite hydrogel films has been analyzed in adipose tissue-derived stem cells (ADSCs) and results showed cytocompatibility of CMC/ZnO-MCM-41. Based on these results the prepared CMC nanocomposite hydrogel containing ZnO impregnated MCM-41, could serve as a kind of promising wound dressing with sustained drug delivery properties. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/28183632/A_potential_bioactive_wound_dressing_based_on_carboxymethyl_cellulose/ZnO_impregnated_MCM_41_nanocomposite_hydrogel_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(16)32756-4 DB - PRIME DP - Unbound Medicine ER -