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Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering.

Abstract

Magnetic nanoparticles have been one of the most attractive nanomaterials for various biomedical applications including magnetic resonance imaging (MRI), diagnostic contrast enhancement, magnetic cell separation, and targeted drug delivery. Three-dimensional (3-D) fibrous scaffolds have broad application prospects in the biomedical field, such as drug delivery and tissue engineering. In this work, a novel three-dimensional composite membrane composed of the tri-block copolymer poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) and magnetic iron oxide nanoparticles (Fe3O4 NPs) were fabricated using electrospinning technology. The physico-chemical properties of the PCEC/Fe3O4 membranes were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Morphological observation using scanning electron microscopy (SEM) showed that the composite fibers containing 5% Fe3O4 nanoparticles had a diameter of 250nm. In vitro cell culture of NIH 3T3 cells on the PCEC/Fe3O4 membranes showed that the PCEC/Fe3O4 fibers might be a suitable scaffold for cell adhesion. Moreover, MTT analysis also demonstrated that the membranes possessed lower cytotoxicity. Therefore, this study revealed that the magnetic PCEC/Fe3O4 fibers might have great potential for using in skin tissue engineering.

Authors+Show Affiliations

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, PR China.Department of Science and Technology, Southwest Medical University, Luzhou 646000, PR China.Health Management Center, The Affiliated Hospital (TCM) of Southwest Medical University, Luzhou 646000, PR China.Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, PR China.Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, PR China.Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, PR China.Experiment Center of Basic Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, PR China.Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, PR China. Electronic address: wjb6147@163.com.Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, PR China. Electronic address: shaozhifu513@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28183642

Citation

Zhang, Heng, et al. "Magnetic Nanoparticle-loaded Electrospun Polymeric Nanofibers for Tissue Engineering." Materials Science & Engineering. C, Materials for Biological Applications, vol. 73, 2017, pp. 537-543.
Zhang H, Xia J, Pang X, et al. Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering. Mater Sci Eng C Mater Biol Appl. 2017;73:537-543.
Zhang, H., Xia, J., Pang, X., Zhao, M., Wang, B., Yang, L., ... Fu, S. (2017). Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering. Materials Science & Engineering. C, Materials for Biological Applications, 73, pp. 537-543. doi:10.1016/j.msec.2016.12.116.
Zhang H, et al. Magnetic Nanoparticle-loaded Electrospun Polymeric Nanofibers for Tissue Engineering. Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:537-543. PubMed PMID: 28183642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering. AU - Zhang,Heng, AU - Xia,JiYi, AU - Pang,XianLun, AU - Zhao,Ming, AU - Wang,BiQiong, AU - Yang,LingLin, AU - Wan,HaiSu, AU - Wu,JingBo, AU - Fu,ShaoZhi, Y1 - 2016/12/24/ PY - 2016/05/30/received PY - 2016/11/29/revised PY - 2016/12/22/accepted PY - 2017/2/11/entrez PY - 2017/2/12/pubmed PY - 2017/5/27/medline KW - Composite fibers KW - Electrospinning KW - Magentic nanoparticles KW - Poly(ε-caprolactone)-poly(ethylene glycol) copolymer KW - Tissue engineering SP - 537 EP - 543 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 73 N2 - Magnetic nanoparticles have been one of the most attractive nanomaterials for various biomedical applications including magnetic resonance imaging (MRI), diagnostic contrast enhancement, magnetic cell separation, and targeted drug delivery. Three-dimensional (3-D) fibrous scaffolds have broad application prospects in the biomedical field, such as drug delivery and tissue engineering. In this work, a novel three-dimensional composite membrane composed of the tri-block copolymer poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) and magnetic iron oxide nanoparticles (Fe3O4 NPs) were fabricated using electrospinning technology. The physico-chemical properties of the PCEC/Fe3O4 membranes were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Morphological observation using scanning electron microscopy (SEM) showed that the composite fibers containing 5% Fe3O4 nanoparticles had a diameter of 250nm. In vitro cell culture of NIH 3T3 cells on the PCEC/Fe3O4 membranes showed that the PCEC/Fe3O4 fibers might be a suitable scaffold for cell adhesion. Moreover, MTT analysis also demonstrated that the membranes possessed lower cytotoxicity. Therefore, this study revealed that the magnetic PCEC/Fe3O4 fibers might have great potential for using in skin tissue engineering. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/28183642/Magnetic_nanoparticle_loaded_electrospun_polymeric_nanofibers_for_tissue_engineering_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(16)32789-8 DB - PRIME DP - Unbound Medicine ER -