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Biological activity of green-synthesized silver nanoparticles depends on the applied natural extracts: a comprehensive study.
Int J Nanomedicine. 2017; 12:871-883.IJ

Abstract

Due to obvious disadvantages of the classical chemical methods, green synthesis of metallic nanoparticles has attracted tremendous attention in recent years. Numerous environmentally benign synthesis methods have been developed yielding nanoparticles via low-cost, eco-friendly, and simple approaches. In this study, our aim was to determine the suitability of coffee and green tea extracts in green synthesis of silver nanoparticles as well as to compare the performance of the obtained materials in different biological systems. We successfully produced silver nanoparticles (C-AgNP and GT-AgNP) using coffee and green tea extracts; moreover, based on our comprehensive screening, we delineated major differences in the biological activity of C-AgNPs and GT-AgNPs. Our results indicate that although GT-AgNPs exhibited excellent antimicrobial activity against all the examined microbial pathogens, these particles were also highly toxic to mammalian cells, which limits their potential applications. On the contrary, C-AgNPs manifested substantial inhibitory action on the tested microbes but were nontoxic to human and mouse cells, indicating an outstanding capacity to discriminate between potential pathogens and mammalian cells. These results clearly show that the various green materials used for stabilization and for reduction of metal ions have a defining role in determining and fine-tuning the biological activity of the obtained nanoparticles.

Authors+Show Affiliations

Department of Applied and Environmental Chemistry.Department of Biochemistry and Molecular Biology.Department of Biochemistry and Molecular Biology.Department of Microbiology, University of Szeged.Department of Biochemistry and Molecular Biology; Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences.Department of Applied and Environmental Chemistry; MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary.Department of Microbiology, University of Szeged.Department of Biochemistry and Molecular Biology.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28184158

Citation

Rónavári, Andrea, et al. "Biological Activity of Green-synthesized Silver Nanoparticles Depends On the Applied Natural Extracts: a Comprehensive Study." International Journal of Nanomedicine, vol. 12, 2017, pp. 871-883.
Rónavári A, Kovács D, Igaz N, et al. Biological activity of green-synthesized silver nanoparticles depends on the applied natural extracts: a comprehensive study. Int J Nanomedicine. 2017;12:871-883.
Rónavári, A., Kovács, D., Igaz, N., Vágvölgyi, C., Boros, I. M., Kónya, Z., Pfeiffer, I., & Kiricsi, M. (2017). Biological activity of green-synthesized silver nanoparticles depends on the applied natural extracts: a comprehensive study. International Journal of Nanomedicine, 12, 871-883. https://doi.org/10.2147/IJN.S122842
Rónavári A, et al. Biological Activity of Green-synthesized Silver Nanoparticles Depends On the Applied Natural Extracts: a Comprehensive Study. Int J Nanomedicine. 2017;12:871-883. PubMed PMID: 28184158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biological activity of green-synthesized silver nanoparticles depends on the applied natural extracts: a comprehensive study. AU - Rónavári,Andrea, AU - Kovács,Dávid, AU - Igaz,Nóra, AU - Vágvölgyi,Csaba, AU - Boros,Imre Miklós, AU - Kónya,Zoltán, AU - Pfeiffer,Ilona, AU - Kiricsi,Mónika, Y1 - 2017/01/27/ PY - 2017/2/11/entrez PY - 2017/2/12/pubmed PY - 2017/4/5/medline KW - antimicrobial activity KW - green synthesis KW - silver nanoparticles KW - toxicity SP - 871 EP - 883 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 12 N2 - Due to obvious disadvantages of the classical chemical methods, green synthesis of metallic nanoparticles has attracted tremendous attention in recent years. Numerous environmentally benign synthesis methods have been developed yielding nanoparticles via low-cost, eco-friendly, and simple approaches. In this study, our aim was to determine the suitability of coffee and green tea extracts in green synthesis of silver nanoparticles as well as to compare the performance of the obtained materials in different biological systems. We successfully produced silver nanoparticles (C-AgNP and GT-AgNP) using coffee and green tea extracts; moreover, based on our comprehensive screening, we delineated major differences in the biological activity of C-AgNPs and GT-AgNPs. Our results indicate that although GT-AgNPs exhibited excellent antimicrobial activity against all the examined microbial pathogens, these particles were also highly toxic to mammalian cells, which limits their potential applications. On the contrary, C-AgNPs manifested substantial inhibitory action on the tested microbes but were nontoxic to human and mouse cells, indicating an outstanding capacity to discriminate between potential pathogens and mammalian cells. These results clearly show that the various green materials used for stabilization and for reduction of metal ions have a defining role in determining and fine-tuning the biological activity of the obtained nanoparticles. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/28184158/Biological_activity_of_green_synthesized_silver_nanoparticles_depends_on_the_applied_natural_extracts:_a_comprehensive_study_ L2 - https://dx.doi.org/10.2147/IJN.S122842 DB - PRIME DP - Unbound Medicine ER -