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Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus.
Neurochem Res 2017; 42(5):1387-1393NR

Abstract

The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep spindles and augment the firing rate of neurons in ventrolateral preoptic nucleus, but the underlining mechanism is yet to be known. By using patch clamp recording on neuron in acute brain slice, present study tested if histaminergic H1 and H2 receptors play a role in the effect of propofol on the noradrenalin-inhibited neurons in ventrolateral preoptic nucleus. We found that the firing rate of noradrenalin-inhibited neurons were significantly augmented by propofol; the frequency of inhibitory postsynaptic currents of noradrenalin-inhibited neuron were evidently attenuated by propofol; such inhibition effect was suppressed by histamine; and both triprolidine (antagonist for H1 histamine receptor) and ranitidine (antagonist for H2 histamine receptor) were able to increase the inhibition rate of propofol in presence of histamine. Present study demonstrated that propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibited neurons were mediated by histaminergic H1 and H2 receptors.

Authors+Show Affiliations

Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, Zunyi, 563000, China.Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, 563000, China.Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, Zunyi, 563000, China.Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, 563000, China.Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, 563000, China. dllyutian@163.com. Zunyi Medical College, Dalian road 149, Zunyi, 563000, Guizhou, China. dllyutian@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28185047

Citation

Liu, Yang, et al. "Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol On the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus." Neurochemical Research, vol. 42, no. 5, 2017, pp. 1387-1393.
Liu Y, Zhang Y, Qian K, et al. Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus. Neurochem Res. 2017;42(5):1387-1393.
Liu, Y., Zhang, Y., Qian, K., Zhang, L., & Yu, T. (2017). Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus. Neurochemical Research, 42(5), pp. 1387-1393. doi:10.1007/s11064-017-2187-y.
Liu Y, et al. Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol On the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus. Neurochem Res. 2017;42(5):1387-1393. PubMed PMID: 28185047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus. AU - Liu,Yang, AU - Zhang,Yu, AU - Qian,Kun, AU - Zhang,Lin, AU - Yu,Tian, Y1 - 2017/02/09/ PY - 2016/09/18/received PY - 2017/01/19/accepted PY - 2017/01/19/revised PY - 2017/2/12/pubmed PY - 2018/1/10/medline PY - 2017/2/11/entrez KW - General anesthesia KW - Inhibitory postsynaptic currents KW - Propofol KW - Ventrolateral preoptic nucleus SP - 1387 EP - 1393 JF - Neurochemical research JO - Neurochem. Res. VL - 42 IS - 5 N2 - The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep spindles and augment the firing rate of neurons in ventrolateral preoptic nucleus, but the underlining mechanism is yet to be known. By using patch clamp recording on neuron in acute brain slice, present study tested if histaminergic H1 and H2 receptors play a role in the effect of propofol on the noradrenalin-inhibited neurons in ventrolateral preoptic nucleus. We found that the firing rate of noradrenalin-inhibited neurons were significantly augmented by propofol; the frequency of inhibitory postsynaptic currents of noradrenalin-inhibited neuron were evidently attenuated by propofol; such inhibition effect was suppressed by histamine; and both triprolidine (antagonist for H1 histamine receptor) and ranitidine (antagonist for H2 histamine receptor) were able to increase the inhibition rate of propofol in presence of histamine. Present study demonstrated that propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibited neurons were mediated by histaminergic H1 and H2 receptors. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/28185047/Histaminergic_H1_and_H2_Receptors_Mediate_the_Effects_of_Propofol_on_the_Noradrenalin-Inhibited_Neurons_in_Rat_Ventrolateral_Preoptic_Nucleus L2 - https://doi.org/10.1007/s11064-017-2187-y DB - PRIME DP - Unbound Medicine ER -