Tags

Type your tag names separated by a space and hit enter

Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India.
PLoS Negl Trop Dis. 2017 02; 11(2):e0005391.PN

Abstract

Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation. Out of 2890 total population, 2603 were screened. Antileishmanial antibody was detected in 185 individuals of them 96 had a history of VL/PKDL and 89 without such history. Seventy nine such individuals were classified as asymptomatic leishmaniasis and ten as active VL with a ratio of 7.9:1. Out of 79 asymptomatic cases 2 were lost to follow up as they moved to other places. Amongst asymptomatically infected persons, disease transformation in 8/77 (10.39%) and sero-conversion in 62/77 (80.52%) cases were noted. Seven (9.09%) remained sero-positive even after three years. Progression to clinical disease among asymptomatic individuals was taking place at any time up to three years after the baseline survey. If there are no VL /PKDL cases for two or more years, it does not mean that the area is free from leishmaniasis as symptomatic VL or PKDL may appear even after three years, if there are such asymptomatic cases. So, asymptomatic infected individuals need much attention for VL elimination programme that has been initiated by three adjoining endemic countries.

Authors+Show Affiliations

Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India. Department of Zoology, A. P. C. Roy Govt. College, Himachal Bihar, Matigara, Siliguri, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India. Department of Microbiology, N. R. S. Medical College & Hospital, Kolkata, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India. Malda Medical College, Malda, West Bengal, India.Department of Tropical Medicine, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India. Medinipur Medical College, West Medinipur, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28187202

Citation

Saha, Pabitra, et al. "Asymptomatic Leishmaniasis in Kala-azar Endemic Areas of Malda District, West Bengal, India." PLoS Neglected Tropical Diseases, vol. 11, no. 2, 2017, pp. e0005391.
Saha P, Ganguly S, Chatterjee M, et al. Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. PLoS Negl Trop Dis. 2017;11(2):e0005391.
Saha, P., Ganguly, S., Chatterjee, M., Das, S. B., Kundu, P. K., Guha, S. K., Ghosh, T. K., Bera, D. K., Basu, N., & Maji, A. K. (2017). Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. PLoS Neglected Tropical Diseases, 11(2), e0005391. https://doi.org/10.1371/journal.pntd.0005391
Saha P, et al. Asymptomatic Leishmaniasis in Kala-azar Endemic Areas of Malda District, West Bengal, India. PLoS Negl Trop Dis. 2017;11(2):e0005391. PubMed PMID: 28187202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. AU - Saha,Pabitra, AU - Ganguly,Swagata, AU - Chatterjee,Moytrey, AU - Das,Soumendu Bikash, AU - Kundu,Pratip K, AU - Guha,Subhasish K, AU - Ghosh,Tamal K, AU - Bera,Dilip K, AU - Basu,Nandita, AU - Maji,Ardhendu K, Y1 - 2017/02/10/ PY - 2016/10/05/received PY - 2017/02/06/accepted PY - 2017/02/23/revised PY - 2017/2/12/pubmed PY - 2017/7/14/medline PY - 2017/2/11/entrez SP - e0005391 EP - e0005391 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 11 IS - 2 N2 - Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation. Out of 2890 total population, 2603 were screened. Antileishmanial antibody was detected in 185 individuals of them 96 had a history of VL/PKDL and 89 without such history. Seventy nine such individuals were classified as asymptomatic leishmaniasis and ten as active VL with a ratio of 7.9:1. Out of 79 asymptomatic cases 2 were lost to follow up as they moved to other places. Amongst asymptomatically infected persons, disease transformation in 8/77 (10.39%) and sero-conversion in 62/77 (80.52%) cases were noted. Seven (9.09%) remained sero-positive even after three years. Progression to clinical disease among asymptomatic individuals was taking place at any time up to three years after the baseline survey. If there are no VL /PKDL cases for two or more years, it does not mean that the area is free from leishmaniasis as symptomatic VL or PKDL may appear even after three years, if there are such asymptomatic cases. So, asymptomatic infected individuals need much attention for VL elimination programme that has been initiated by three adjoining endemic countries. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/28187202/Asymptomatic_leishmaniasis_in_kala_azar_endemic_areas_of_Malda_district_West_Bengal_India_ L2 - https://dx.plos.org/10.1371/journal.pntd.0005391 DB - PRIME DP - Unbound Medicine ER -