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Toxicological investigation of forensic cases related to the designer drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, quantification and studies on human metabolism by GC-MS.
Forensic Sci Int. 2017 Apr; 273:1-9.FS

Abstract

3,4-methylenedioxypyrovalerone (MDPV) is a synthetic cathinone belonging to the class of α-pyrrolidinophenones that become increasingly popular as a designer psychostimulant. Here, we report a comprehensive collection of MDPV exposure with quantitative serum level confirmation in Germany. During the years 2014-2016, we could proof consumption of MDPV in 23 cases where urine and blood samples were submitted to our laboratory by the police of Lower Saxony. Most of the samples underwent systematic toxicological analysis by gas chromatography-mass spectrometry (GC-MS), where MDPV could be detected in urine and/or serum samples. The determined concentrations of MDPV in serum showed a high variability, ranging from traces (<10ng/mL) up to 576ng/mL with a mean concentration of 118ng/mL and median of 47ng/mL. The majority of MDPV users were men (87%) and the age ranged from 23 to 49 years (mean 35.9, median 37 years). For most of the analytically confirmed MDPV cases we could prove co-consumption of other psychotropic drugs with frequent occurrence of opiates and cannabinoids in 22% of the cases, followed by benzodiazepines and cocaine in 17%. Analysis of urine samples by GC-MS disclosed the presence of MDPV and its metabolites 2'-oxo-MDPV, demethylenyl-MDPV, demethylenyl-methyl-MDPV, demethylenyl-oxo-MDPV, demethylenyl-methyl-oxo-MDPV and demethylenyl-methyl-N,N-bisdealkyl-MDPV. The metabolite pattern substantiates previous suggestions for principle metabolic pathways of MDPV in humans.

Authors+Show Affiliations

Forensic Toxicological Laboratory, University Medical Center Göttingen, Georg-August-University, 37075 Göttingen, Germany. Electronic address: mgrapp@med.uni-goettingen.de.Forensic Toxicological Laboratory, University Medical Center Göttingen, Georg-August-University, 37075 Göttingen, Germany.GIZ-Nord Poisons Center, University Medical Center Göttingen, Georg-August-University, 37075 Göttingen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28187296

Citation

Grapp, Marcel, et al. "Toxicological Investigation of Forensic Cases Related to the Designer Drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, Quantification and Studies On Human Metabolism By GC-MS." Forensic Science International, vol. 273, 2017, pp. 1-9.
Grapp M, Kaufmann C, Ebbecke M. Toxicological investigation of forensic cases related to the designer drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, quantification and studies on human metabolism by GC-MS. Forensic Sci Int. 2017;273:1-9.
Grapp, M., Kaufmann, C., & Ebbecke, M. (2017). Toxicological investigation of forensic cases related to the designer drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, quantification and studies on human metabolism by GC-MS. Forensic Science International, 273, 1-9. https://doi.org/10.1016/j.forsciint.2017.01.021
Grapp M, Kaufmann C, Ebbecke M. Toxicological Investigation of Forensic Cases Related to the Designer Drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, Quantification and Studies On Human Metabolism By GC-MS. Forensic Sci Int. 2017;273:1-9. PubMed PMID: 28187296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicological investigation of forensic cases related to the designer drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, quantification and studies on human metabolism by GC-MS. AU - Grapp,Marcel, AU - Kaufmann,Christoph, AU - Ebbecke,Martin, Y1 - 2017/02/02/ PY - 2016/10/10/received PY - 2017/01/18/revised PY - 2017/01/22/accepted PY - 2017/2/12/pubmed PY - 2018/5/31/medline PY - 2017/2/11/entrez KW - 3,4-methylenedioxypyrovalerone KW - MDPV KW - New psychoactive substances KW - Pyrrolidinophenone KW - Synthetic cathinones KW - Systematic toxicological analysis SP - 1 EP - 9 JF - Forensic science international JO - Forensic Sci. Int. VL - 273 N2 - 3,4-methylenedioxypyrovalerone (MDPV) is a synthetic cathinone belonging to the class of α-pyrrolidinophenones that become increasingly popular as a designer psychostimulant. Here, we report a comprehensive collection of MDPV exposure with quantitative serum level confirmation in Germany. During the years 2014-2016, we could proof consumption of MDPV in 23 cases where urine and blood samples were submitted to our laboratory by the police of Lower Saxony. Most of the samples underwent systematic toxicological analysis by gas chromatography-mass spectrometry (GC-MS), where MDPV could be detected in urine and/or serum samples. The determined concentrations of MDPV in serum showed a high variability, ranging from traces (<10ng/mL) up to 576ng/mL with a mean concentration of 118ng/mL and median of 47ng/mL. The majority of MDPV users were men (87%) and the age ranged from 23 to 49 years (mean 35.9, median 37 years). For most of the analytically confirmed MDPV cases we could prove co-consumption of other psychotropic drugs with frequent occurrence of opiates and cannabinoids in 22% of the cases, followed by benzodiazepines and cocaine in 17%. Analysis of urine samples by GC-MS disclosed the presence of MDPV and its metabolites 2'-oxo-MDPV, demethylenyl-MDPV, demethylenyl-methyl-MDPV, demethylenyl-oxo-MDPV, demethylenyl-methyl-oxo-MDPV and demethylenyl-methyl-N,N-bisdealkyl-MDPV. The metabolite pattern substantiates previous suggestions for principle metabolic pathways of MDPV in humans. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/28187296/Toxicological_investigation_of_forensic_cases_related_to_the_designer_drug_34_methylenedioxypyrovalerone__MDPV_:_Detection_quantification_and_studies_on_human_metabolism_by_GC_MS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(17)30035-X DB - PRIME DP - Unbound Medicine ER -