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Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment.
Am J Ophthalmol. 2017 May; 177:17-26.AJ

Abstract

PURPOSE

To investigate the regeneration of the cone outer segments in eyes after surgery for fovea-off rhegmatogenous retinal detachment with an adaptive optics (AO) fundus camera and to correlate these findings with the findings of optical coherence tomography (OCT).

DESIGN

Retrospective, observational case series.

METHODS

Medical charts of 21 eyes of 21 patients who had undergone surgery for fovea-off rhegmatogenous retinal detachment were retrospectively studied. Cone mosaic images were obtained with an AO fundus camera. Cone packing density at 2 degrees from the fovea within the previously detached area was measured 6 and 12 months after surgery. Retinal thicknesses between the interdigitation zone and the retinal pigment epithelium (IZ-RPE) and between the ellipsoid zone and the retinal pigment epithelium (EZ-RPE) were measured in OCT images.

RESULTS

Cone density 12 months after surgery was significantly increased from that at 6 months (P = .001), but was still significantly lower than that of normal fellow eyes (P < .001). IZ-RPE and EZ-RPE thickness significantly increased from 6 to 12 months (P = .045, P = .033, respectively), and these values were not significantly different from those of normal fellow eyes. Multivariate analysis showed that cone density at 12 months was significantly associated with IZ-RPE thickness (P = .002), and increases in cone packing density were significantly associated with increases in IZ-RPE thickness (P = .001).

CONCLUSIONS

Recovery of cone packing density measured by AO was associated with structural recovery of the outer retina observed in OCT, suggesting regeneration of the photoreceptor outer segment after surgery.

Authors+Show Affiliations

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: yasu@med.nagoya-u.ac.jp.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: terasaki@med.nagoya-u.ac.jp.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28189482

Citation

Ra, Eimei, et al. "Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment." American Journal of Ophthalmology, vol. 177, 2017, pp. 17-26.
Ra E, Ito Y, Kawano K, et al. Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment. Am J Ophthalmol. 2017;177:17-26.
Ra, E., Ito, Y., Kawano, K., Iwase, T., Kaneko, H., Ueno, S., Yasuda, S., Kataoka, K., & Terasaki, H. (2017). Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment. American Journal of Ophthalmology, 177, 17-26. https://doi.org/10.1016/j.ajo.2017.01.032
Ra E, et al. Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment. Am J Ophthalmol. 2017;177:17-26. PubMed PMID: 28189482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment. AU - Ra,Eimei, AU - Ito,Yasuki, AU - Kawano,Kenichi, AU - Iwase,Takeshi, AU - Kaneko,Hiroki, AU - Ueno,Shinji, AU - Yasuda,Shunsuke, AU - Kataoka,Keiko, AU - Terasaki,Hiroko, Y1 - 2017/02/09/ PY - 2016/10/30/received PY - 2017/01/28/revised PY - 2017/01/30/accepted PY - 2017/2/13/pubmed PY - 2017/7/20/medline PY - 2017/2/13/entrez SP - 17 EP - 26 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 177 N2 - PURPOSE: To investigate the regeneration of the cone outer segments in eyes after surgery for fovea-off rhegmatogenous retinal detachment with an adaptive optics (AO) fundus camera and to correlate these findings with the findings of optical coherence tomography (OCT). DESIGN: Retrospective, observational case series. METHODS: Medical charts of 21 eyes of 21 patients who had undergone surgery for fovea-off rhegmatogenous retinal detachment were retrospectively studied. Cone mosaic images were obtained with an AO fundus camera. Cone packing density at 2 degrees from the fovea within the previously detached area was measured 6 and 12 months after surgery. Retinal thicknesses between the interdigitation zone and the retinal pigment epithelium (IZ-RPE) and between the ellipsoid zone and the retinal pigment epithelium (EZ-RPE) were measured in OCT images. RESULTS: Cone density 12 months after surgery was significantly increased from that at 6 months (P = .001), but was still significantly lower than that of normal fellow eyes (P < .001). IZ-RPE and EZ-RPE thickness significantly increased from 6 to 12 months (P = .045, P = .033, respectively), and these values were not significantly different from those of normal fellow eyes. Multivariate analysis showed that cone density at 12 months was significantly associated with IZ-RPE thickness (P = .002), and increases in cone packing density were significantly associated with increases in IZ-RPE thickness (P = .001). CONCLUSIONS: Recovery of cone packing density measured by AO was associated with structural recovery of the outer retina observed in OCT, suggesting regeneration of the photoreceptor outer segment after surgery. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/28189482/Regeneration_of_Photoreceptor_Outer_Segments_After_Scleral_Buckling_Surgery_for_Rhegmatogenous_Retinal_Detachment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(17)30056-9 DB - PRIME DP - Unbound Medicine ER -