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Effects of interpersonal violence-related post-traumatic stress disorder (PTSD) on mother and child diurnal cortisol rhythm and cortisol reactivity to a laboratory stressor involving separation.
Horm Behav. 2017 04; 90:15-24.HB

Abstract

Women who have experienced interpersonal violence (IPV) are at a higher risk to develop posttraumatic stress disorder (PTSD), with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and impaired social behavior. Previously, we had reported impaired maternal sensitivity and increased difficulty in identifying emotions (i.e. alexithymia) among IPV-PTSD mothers. One of the aims of the present study was to examine maternal IPV-PTSD salivary cortisol levels diurnally and reactive to their child's distress in relation to maternal alexithymia. Given that mother-child interaction during infancy and early childhood has important long-term consequences on the stress response system, toddlers' cortisol levels were assessed during the day and in response to a laboratory stressor. Mothers collected their own and their 12-48month-old toddlers' salivary samples at home three times: 30min after waking up, between 2-3pm and at bedtime. Moreover, mother-child dyads participated in a 120-min laboratory session, consisting of 3 phases: baseline, stress situation (involving mother-child separation and exposure to novelty) and a 60-min regulation phase. Compared to non-PTSD controls, IPV-PTSD mothers - but not their toddlers, had lower morning cortisol and higher bedtime cortisol levels. As expected, IPV-PTSD mothers and their children showed blunted cortisol reactivity to the laboratory stressor. Maternal cortisol levels were negatively correlated to difficulty in identifying emotions. Our data highlights PTSD-IPV-related alterations in the HPA system and its relevance to maternal behavior. Toddlers of IPV-PTSD mothers also showed an altered pattern of cortisol reactivity to stress that potentially may predispose them to later psychological disorders.

Authors+Show Affiliations

Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester, UK; Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland. Electronic address: m.cordero@mmu.ac.uk.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland.Clinical Chemistry and Toxicology Service, Hôpital du Valais, Sion, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland; Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland; Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland.Research Unit, Child and Adolescent Psychiatry Service, University of Geneva Hospitals, Geneva, Switzerland; Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Division of Developmental Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28189641

Citation

Cordero, Maria I., et al. "Effects of Interpersonal Violence-related Post-traumatic Stress Disorder (PTSD) On Mother and Child Diurnal Cortisol Rhythm and Cortisol Reactivity to a Laboratory Stressor Involving Separation." Hormones and Behavior, vol. 90, 2017, pp. 15-24.
Cordero MI, Moser DA, Manini A, et al. Effects of interpersonal violence-related post-traumatic stress disorder (PTSD) on mother and child diurnal cortisol rhythm and cortisol reactivity to a laboratory stressor involving separation. Horm Behav. 2017;90:15-24.
Cordero, M. I., Moser, D. A., Manini, A., Suardi, F., Sancho-Rossignol, A., Torrisi, R., Rossier, M. F., Ansermet, F., Dayer, A. G., Rusconi-Serpa, S., & Schechter, D. S. (2017). Effects of interpersonal violence-related post-traumatic stress disorder (PTSD) on mother and child diurnal cortisol rhythm and cortisol reactivity to a laboratory stressor involving separation. Hormones and Behavior, 90, 15-24. https://doi.org/10.1016/j.yhbeh.2017.02.007
Cordero MI, et al. Effects of Interpersonal Violence-related Post-traumatic Stress Disorder (PTSD) On Mother and Child Diurnal Cortisol Rhythm and Cortisol Reactivity to a Laboratory Stressor Involving Separation. Horm Behav. 2017;90:15-24. PubMed PMID: 28189641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of interpersonal violence-related post-traumatic stress disorder (PTSD) on mother and child diurnal cortisol rhythm and cortisol reactivity to a laboratory stressor involving separation. AU - Cordero,Maria I, AU - Moser,Dominik A, AU - Manini,Aurelia, AU - Suardi,Francesca, AU - Sancho-Rossignol,Ana, AU - Torrisi,Raffaella, AU - Rossier,Michel F, AU - Ansermet,François, AU - Dayer,Alexandre G, AU - Rusconi-Serpa,Sandra, AU - Schechter,Daniel S, Y1 - 2017/02/20/ PY - 2016/05/11/received PY - 2016/12/23/revised PY - 2017/02/05/accepted PY - 2017/2/13/pubmed PY - 2017/12/27/medline PY - 2017/2/13/entrez KW - Alexithymia KW - Cortisol KW - Early childhood KW - Glucocorticoids KW - HPA-axis KW - Intergenerational KW - Interpersonal violence KW - PTSD KW - Risk KW - Toddlers SP - 15 EP - 24 JF - Hormones and behavior JO - Horm Behav VL - 90 N2 - Women who have experienced interpersonal violence (IPV) are at a higher risk to develop posttraumatic stress disorder (PTSD), with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and impaired social behavior. Previously, we had reported impaired maternal sensitivity and increased difficulty in identifying emotions (i.e. alexithymia) among IPV-PTSD mothers. One of the aims of the present study was to examine maternal IPV-PTSD salivary cortisol levels diurnally and reactive to their child's distress in relation to maternal alexithymia. Given that mother-child interaction during infancy and early childhood has important long-term consequences on the stress response system, toddlers' cortisol levels were assessed during the day and in response to a laboratory stressor. Mothers collected their own and their 12-48month-old toddlers' salivary samples at home three times: 30min after waking up, between 2-3pm and at bedtime. Moreover, mother-child dyads participated in a 120-min laboratory session, consisting of 3 phases: baseline, stress situation (involving mother-child separation and exposure to novelty) and a 60-min regulation phase. Compared to non-PTSD controls, IPV-PTSD mothers - but not their toddlers, had lower morning cortisol and higher bedtime cortisol levels. As expected, IPV-PTSD mothers and their children showed blunted cortisol reactivity to the laboratory stressor. Maternal cortisol levels were negatively correlated to difficulty in identifying emotions. Our data highlights PTSD-IPV-related alterations in the HPA system and its relevance to maternal behavior. Toddlers of IPV-PTSD mothers also showed an altered pattern of cortisol reactivity to stress that potentially may predispose them to later psychological disorders. SN - 1095-6867 UR - https://www.unboundmedicine.com/medline/citation/28189641/Effects_of_interpersonal_violence_related_post_traumatic_stress_disorder__PTSD__on_mother_and_child_diurnal_cortisol_rhythm_and_cortisol_reactivity_to_a_laboratory_stressor_involving_separation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0018-506X(16)30216-1 DB - PRIME DP - Unbound Medicine ER -