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Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression.
Exp Dermatol. 2017 10; 26(10):958-960.ED

Abstract

Sebum production and excretion is a primary function of the sebaceous glands, but abnormally increased sebum production is a major cause of acne vulgaris. To identify a new candidate that regulates sebum production, we investigated the possible inhibitory effects of apple polyphenols (APP) purified from unripe apples on primary cultured human sebocytes and in patients with acne vulgaris. Dexamethasone (Dex) increased lipid synthesis and expression of the sterol response element-binding protein 1 (SREBP 1) and its target enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), in the sebocytes. However, APP inhibited Dex-induced lipid production and expression of SREBP-1, ACC and FAS. APP also inhibited the increase in the expression and activation of glucocorticoid receptor in the sebocytes. Taken together, these results suggest that APP may be useful to regulate sebum production and may alleviate sebum-involved skin disease, such as acne vulgaris.

Authors+Show Affiliations

R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.Department of Dermatology, Kyungpook National University School of Medicine, Daegu, South Korea.R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28191675

Citation

Lee, Kyung-Eun, et al. "Polyphenol-rich Apple Extract Inhibits Dexamethasone-induced Sebaceous Lipids Production By Regulating SREBP1 Expression." Experimental Dermatology, vol. 26, no. 10, 2017, pp. 958-960.
Lee KE, Youm JK, Lee WJ, et al. Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression. Exp Dermatol. 2017;26(10):958-960.
Lee, K. E., Youm, J. K., Lee, W. J., Kang, S., & Kim, Y. J. (2017). Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression. Experimental Dermatology, 26(10), 958-960. https://doi.org/10.1111/exd.13319
Lee KE, et al. Polyphenol-rich Apple Extract Inhibits Dexamethasone-induced Sebaceous Lipids Production By Regulating SREBP1 Expression. Exp Dermatol. 2017;26(10):958-960. PubMed PMID: 28191675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression. AU - Lee,Kyung-Eun, AU - Youm,Jong-Kyung, AU - Lee,Weon Ju, AU - Kang,Seunghyun, AU - Kim,Youn Joon, Y1 - 2017/04/21/ PY - 2017/02/08/accepted PY - 2017/2/14/pubmed PY - 2018/7/19/medline PY - 2017/2/14/entrez KW - Polyphenol-rich apple extract KW - acne vulgaris KW - sebocytes KW - sebum KW - sterol response element-binding protein 1 SP - 958 EP - 960 JF - Experimental dermatology JO - Exp. Dermatol. VL - 26 IS - 10 N2 - Sebum production and excretion is a primary function of the sebaceous glands, but abnormally increased sebum production is a major cause of acne vulgaris. To identify a new candidate that regulates sebum production, we investigated the possible inhibitory effects of apple polyphenols (APP) purified from unripe apples on primary cultured human sebocytes and in patients with acne vulgaris. Dexamethasone (Dex) increased lipid synthesis and expression of the sterol response element-binding protein 1 (SREBP 1) and its target enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), in the sebocytes. However, APP inhibited Dex-induced lipid production and expression of SREBP-1, ACC and FAS. APP also inhibited the increase in the expression and activation of glucocorticoid receptor in the sebocytes. Taken together, these results suggest that APP may be useful to regulate sebum production and may alleviate sebum-involved skin disease, such as acne vulgaris. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/28191675/Polyphenol_rich_apple_extract_inhibits_dexamethasone_induced_sebaceous_lipids_production_by_regulating_SREBP1_expression_ L2 - https://doi.org/10.1111/exd.13319 DB - PRIME DP - Unbound Medicine ER -