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Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats.
Biomed Pharmacother. 2017 Apr; 88:1069-1079.BP

Abstract

Betanin, a chromoalkaloid of beetroot, has shown significant biological effects of antioxidants, anti-inflammatory and anticarcinogenic activities. So, we attempted to determine whether betanin (a natural pigment) would be protective against hyperglycemia in streptozotocin (STZ) - nicotinamide (NA) induced diabetic rats. Rats were injected with STZ (40mg/kgb.w.) 15 mins after the administration of NA (110mg/kgb.w.) by intraperitonially (i.p.) 30days for the induction of experimental diabetes mellitus. After 72h diabetic rats were treated with betanin orally at a doses of 10, 20 and 40mg/kg b.w., respectively in a dose dependent manner and glibenclamide (600μg/kgb.w.). The promising character of betanin against diabetic rats was evaluated by performing the various biochemical parameters and histomorphological changes in liver and pancreas. Among the three doses, 20mg/kgb.w. of betanin was able to positively regulate plasma glucose, insulin, glycosylated hemoglobin (HbA1c) and hemoglobin (Hb) levels by significantly increasing the activity of glycolytic enzyme (glucokinase and pyruvate kinase), glucose-6-phosphate dehydrogenase and significantly decreasing the activity of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) thereby increasing the glycogen content in the liver. We put forward that betanin could significantly restore the levels of carbohydrate metabolic key enzymes to near normal in diabetic rat. Immunohistochemical observation of pancreas revealed that betanin treated diabetic rats showed increased insulin immunoreactive β-cells, which confirmed the biochemical findings. Taken together, present study suggests that betanin modulates the carbohydrate metabolism and has beneficial effects in glucose homeostasis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidhambaram, 608 002 Tamilnadu, India.Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidhambaram, 608 002 Tamilnadu, India.Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidhambaram, 608 002 Tamilnadu, India. Electronic address: sivaseenu77@gmail.com.Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidhambaram, 608 002 Tamilnadu, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28192880

Citation

Dhananjayan, Indumathi, et al. "Ameliorating Effect of Betanin, a Natural Chromoalkaloid By Modulating Hepatic Carbohydrate Metabolic Enzyme Activities and Glycogen Content in Streptozotocin - Nicotinamide Induced Experimental Rats." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 88, 2017, pp. 1069-1079.
Dhananjayan I, Kathiroli S, Subramani S, et al. Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats. Biomed Pharmacother. 2017;88:1069-1079.
Dhananjayan, I., Kathiroli, S., Subramani, S., & Veerasamy, V. (2017). Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 88, 1069-1079. https://doi.org/10.1016/j.biopha.2017.01.146
Dhananjayan I, et al. Ameliorating Effect of Betanin, a Natural Chromoalkaloid By Modulating Hepatic Carbohydrate Metabolic Enzyme Activities and Glycogen Content in Streptozotocin - Nicotinamide Induced Experimental Rats. Biomed Pharmacother. 2017;88:1069-1079. PubMed PMID: 28192880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats. AU - Dhananjayan,Indumathi, AU - Kathiroli,Sujithra, AU - Subramani,Srinivasan, AU - Veerasamy,Vinothkumar, Y1 - 2017/02/07/ PY - 2016/11/09/received PY - 2017/01/21/revised PY - 2017/01/26/accepted PY - 2017/2/15/pubmed PY - 2017/3/16/medline PY - 2017/2/15/entrez KW - Betanin KW - Carbohydrate metabolic enzymes KW - Glucose KW - Insulin KW - Streptozotocin – nicotinamide SP - 1069 EP - 1079 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 88 N2 - Betanin, a chromoalkaloid of beetroot, has shown significant biological effects of antioxidants, anti-inflammatory and anticarcinogenic activities. So, we attempted to determine whether betanin (a natural pigment) would be protective against hyperglycemia in streptozotocin (STZ) - nicotinamide (NA) induced diabetic rats. Rats were injected with STZ (40mg/kgb.w.) 15 mins after the administration of NA (110mg/kgb.w.) by intraperitonially (i.p.) 30days for the induction of experimental diabetes mellitus. After 72h diabetic rats were treated with betanin orally at a doses of 10, 20 and 40mg/kg b.w., respectively in a dose dependent manner and glibenclamide (600μg/kgb.w.). The promising character of betanin against diabetic rats was evaluated by performing the various biochemical parameters and histomorphological changes in liver and pancreas. Among the three doses, 20mg/kgb.w. of betanin was able to positively regulate plasma glucose, insulin, glycosylated hemoglobin (HbA1c) and hemoglobin (Hb) levels by significantly increasing the activity of glycolytic enzyme (glucokinase and pyruvate kinase), glucose-6-phosphate dehydrogenase and significantly decreasing the activity of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) thereby increasing the glycogen content in the liver. We put forward that betanin could significantly restore the levels of carbohydrate metabolic key enzymes to near normal in diabetic rat. Immunohistochemical observation of pancreas revealed that betanin treated diabetic rats showed increased insulin immunoreactive β-cells, which confirmed the biochemical findings. Taken together, present study suggests that betanin modulates the carbohydrate metabolism and has beneficial effects in glucose homeostasis. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28192880/Ameliorating_effect_of_betanin_a_natural_chromoalkaloid_by_modulating_hepatic_carbohydrate_metabolic_enzyme_activities_and_glycogen_content_in_streptozotocin___nicotinamide_induced_experimental_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(16)32266-1 DB - PRIME DP - Unbound Medicine ER -