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Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats.
Pharm Biol. 2017 Dec; 55(1):1074-1081.PB

Abstract

CONTEXT

The decoctions of Ficus carica Linn. (Moraceae) leaves are used in the folklore treatment of diabetes.

OBJECTIVE

To evaluate the effect of F. carica on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells protective effects in type 2 diabetes.

MATERIAL AND METHODS

Diabetes was induced in 15 days high-fat diet (HFD)-fed Wistar rats by intraperitoneal injection of streptozotocin (STZ) (40 mg/kg). The ethyl acetate extract (250 and 500 mg/kg) of F. carica leaves was administered for 28 days. Oral glucose tolerance (OGTT) and intraperitoneal insulin tolerance tests (ITT) were evaluated on 15th and 25th days, respectively.

RESULTS

The ethyl acetate extract (250 and 500 mg/kg) of n F. carica leaves showed significant effect (p < 0.005) in the levels of blood glucose, total cholesterol (TC), triglycerides (TG), body weight and hepatic glycogen. In OGTT, F. carica (250 and 500 mg/kg) significantly (p < 0.005) detained the increase in blood glucose levels at 60 and 120 min and in ITT, F. carica enhanced the glucose utilization significantly (p < 0.005) over 30 and 60 min compared to diabetic control. Further, the altered activities of key carbohydrate metabolizing enzymes such as glucose-6-phosphatase, fructose-1,6-bisphosphatase and hexokinase in the liver tissue of diabetic rats were significantly (p < 0.005) reverted to near normal levels upon treatment with F. carica. Immumohistochemical studies of islets substantiated the cytoprotective effect on pancreatic β-cells.

DISCUSSION AND CONCLUSIONS

F. carica leaves exerted significant effect on carbohydrate metabolism enzymes with promising hypoglycemic and hypolipidemic activities in type 2 diabetic rats.

Authors+Show Affiliations

a Division of Ethnopharmacology , Entomology Research Institute, Loyola College , Chennai , India.a Division of Ethnopharmacology , Entomology Research Institute, Loyola College , Chennai , India.b Division of Bioinformatics , Entomology Research Institute, Loyola College , Chennai , India.c Department of Botany and Microbiology , Addiriyah Chair for Environmental Studies, College of Science, King Saud University , Riyadh , Saudi Arabia.c Department of Botany and Microbiology , Addiriyah Chair for Environmental Studies, College of Science, King Saud University , Riyadh , Saudi Arabia.a Division of Ethnopharmacology , Entomology Research Institute, Loyola College , Chennai , India. b Division of Bioinformatics , Entomology Research Institute, Loyola College , Chennai , India. d Visiting Professor Programme, Deanship of Scientific Research , College of Science, King Saud University , Riyadh , Saudi Arabia.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28193094

Citation

Stephen Irudayaraj, Santiagu, et al. "Protective Effects of Ficus Carica Leaves On Glucose and Lipids Levels, Carbohydrate Metabolism Enzymes and Β-cells in Type 2 Diabetic Rats." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 1074-1081.
Stephen Irudayaraj S, Christudas S, Antony S, et al. Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats. Pharm Biol. 2017;55(1):1074-1081.
Stephen Irudayaraj, S., Christudas, S., Antony, S., Duraipandiyan, V., Naif Abdullah, A. D., & Ignacimuthu, S. (2017). Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats. Pharmaceutical Biology, 55(1), 1074-1081. https://doi.org/10.1080/13880209.2017.1279671
Stephen Irudayaraj S, et al. Protective Effects of Ficus Carica Leaves On Glucose and Lipids Levels, Carbohydrate Metabolism Enzymes and Β-cells in Type 2 Diabetic Rats. Pharm Biol. 2017;55(1):1074-1081. PubMed PMID: 28193094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats. AU - Stephen Irudayaraj,Santiagu, AU - Christudas,Sunil, AU - Antony,Stalin, AU - Duraipandiyan,Veeramuthu, AU - Naif Abdullah,Al-Dhabi, AU - Ignacimuthu,Savarimuthu, PY - 2017/2/15/entrez PY - 2017/2/15/pubmed PY - 2017/3/10/medline KW - Ficusin KW - hypoglycemic KW - hypolipidemic SP - 1074 EP - 1081 JF - Pharmaceutical biology JO - Pharm Biol VL - 55 IS - 1 N2 - CONTEXT: The decoctions of Ficus carica Linn. (Moraceae) leaves are used in the folklore treatment of diabetes. OBJECTIVE: To evaluate the effect of F. carica on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells protective effects in type 2 diabetes. MATERIAL AND METHODS: Diabetes was induced in 15 days high-fat diet (HFD)-fed Wistar rats by intraperitoneal injection of streptozotocin (STZ) (40 mg/kg). The ethyl acetate extract (250 and 500 mg/kg) of F. carica leaves was administered for 28 days. Oral glucose tolerance (OGTT) and intraperitoneal insulin tolerance tests (ITT) were evaluated on 15th and 25th days, respectively. RESULTS: The ethyl acetate extract (250 and 500 mg/kg) of n F. carica leaves showed significant effect (p < 0.005) in the levels of blood glucose, total cholesterol (TC), triglycerides (TG), body weight and hepatic glycogen. In OGTT, F. carica (250 and 500 mg/kg) significantly (p < 0.005) detained the increase in blood glucose levels at 60 and 120 min and in ITT, F. carica enhanced the glucose utilization significantly (p < 0.005) over 30 and 60 min compared to diabetic control. Further, the altered activities of key carbohydrate metabolizing enzymes such as glucose-6-phosphatase, fructose-1,6-bisphosphatase and hexokinase in the liver tissue of diabetic rats were significantly (p < 0.005) reverted to near normal levels upon treatment with F. carica. Immumohistochemical studies of islets substantiated the cytoprotective effect on pancreatic β-cells. DISCUSSION AND CONCLUSIONS: F. carica leaves exerted significant effect on carbohydrate metabolism enzymes with promising hypoglycemic and hypolipidemic activities in type 2 diabetic rats. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/28193094/Protective_effects_of_Ficus_carica_leaves_on_glucose_and_lipids_levels_carbohydrate_metabolism_enzymes_and_β_cells_in_type_2_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2017.1279671 DB - PRIME DP - Unbound Medicine ER -