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Salivary oxidative status in patients with oral lichen planus.
J Physiol Pharmacol. 2016 Dec; 67(6):885-894.JP

Abstract

Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. In total, 62 patients with oral lichen planus (OLP) were enrolled in the study, including 31 with the reticular form of lichen planus (44.63 ± 11.05 years) and 31 with erosive forms (40.43 ± 10.05 years), who had never been treated for their disease. The control group comprised 30 individuals without any oral lesions (42.12 ± 12.22 years). We determined the saliva levels in glutathione (GSH), total antioxidant capacity (TAC), and thiobarbituric acid reactive substances (TBARS). The mean saliva levels of GSH and TAC were significantly lower (P < 0.01) in OLP patients compared to the control group. The mean levels of salivary TBARS were higher in both OLP groups (reticular and erosive) compared to the control group (P = 0.01). The lower saliva levels of GSH and TAC in patients with OLP indicate that free radicals and the resulting oxidative damage may play an important role in the pathogenesis of OLP lesions. In conclusion, monitoring the oxidant-antioxidant status of saliva may serve as an efficient and less intrusive marker for determining stages of disease development in patients with OLP.

Authors+Show Affiliations

Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland.Student Scientific Association at the Department of Medical Diagnostics, Jagiellonian University Medical College, Poland.Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.Department of Oral Surgery, Jagiellonian University Medical College, Cracow, Poland.Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland.Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland.Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland. mdgajews@cyf-kr.edu.pl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28195069

Citation

Darczuk, D, et al. "Salivary Oxidative Status in Patients With Oral Lichen Planus." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 67, no. 6, 2016, pp. 885-894.
Darczuk D, Krzysciak W, Vyhouskaya P, et al. Salivary oxidative status in patients with oral lichen planus. J Physiol Pharmacol. 2016;67(6):885-894.
Darczuk, D., Krzysciak, W., Vyhouskaya, P., Kesek, B., Galecka-Wanatowicz, D., Lipska, W., Kaczmarzyk, T., Gluch-Lutwin, M., Mordyl, B., & Chomyszyn-Gajewska, M. (2016). Salivary oxidative status in patients with oral lichen planus. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 67(6), 885-894.
Darczuk D, et al. Salivary Oxidative Status in Patients With Oral Lichen Planus. J Physiol Pharmacol. 2016;67(6):885-894. PubMed PMID: 28195069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary oxidative status in patients with oral lichen planus. AU - Darczuk,D, AU - Krzysciak,W, AU - Vyhouskaya,P, AU - Kesek,B, AU - Galecka-Wanatowicz,D, AU - Lipska,W, AU - Kaczmarzyk,T, AU - Gluch-Lutwin,M, AU - Mordyl,B, AU - Chomyszyn-Gajewska,M, PY - 2016/06/20/received PY - 2016/12/28/accepted PY - 2017/2/15/entrez PY - 2017/2/15/pubmed PY - 2017/6/9/medline SP - 885 EP - 894 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 67 IS - 6 N2 - Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. In total, 62 patients with oral lichen planus (OLP) were enrolled in the study, including 31 with the reticular form of lichen planus (44.63 ± 11.05 years) and 31 with erosive forms (40.43 ± 10.05 years), who had never been treated for their disease. The control group comprised 30 individuals without any oral lesions (42.12 ± 12.22 years). We determined the saliva levels in glutathione (GSH), total antioxidant capacity (TAC), and thiobarbituric acid reactive substances (TBARS). The mean saliva levels of GSH and TAC were significantly lower (P < 0.01) in OLP patients compared to the control group. The mean levels of salivary TBARS were higher in both OLP groups (reticular and erosive) compared to the control group (P = 0.01). The lower saliva levels of GSH and TAC in patients with OLP indicate that free radicals and the resulting oxidative damage may play an important role in the pathogenesis of OLP lesions. In conclusion, monitoring the oxidant-antioxidant status of saliva may serve as an efficient and less intrusive marker for determining stages of disease development in patients with OLP. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/28195069/Salivary_oxidative_status_in_patients_with_oral_lichen_planus_ L2 - http://www.jpp.krakow.pl/journal/archive/12_16/pdf/885_12_16_article.pdf DB - PRIME DP - Unbound Medicine ER -