Tags

Type your tag names separated by a space and hit enter

Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins.
J Agric Food Chem. 2017 Mar 08; 65(9):1893-1899.JA

Abstract

The bioavailability of A-type procyanidins in vivo has been rarely investigated; as such, this study discusses the effect of A-type linkage and degree of polymerization on the metabolism of procyanidins extracted from litchi pericarp (LPOPC). Sprague-Dawley rats were gavaged with (-)-epicatechin (EC) and LPOPC and sacrificed at different time points after ingestion. A-type linkage procyanidin oligomers inhibited the absorption of EC. Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyanidin trimer (A-3) showed distinct native and metabolite profiles for each rat. Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.

Authors+Show Affiliations

College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.College of Chemical Engineering, Tianjin University , Tianjin 300072, People's Republic of China.College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.College of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, Hubei 430023, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28195469

Citation

Li, Shuyi, et al. "Effect of the A-Type Linkage On the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins." Journal of Agricultural and Food Chemistry, vol. 65, no. 9, 2017, pp. 1893-1899.
Li S, Liu Y, Liu G, et al. Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins. J Agric Food Chem. 2017;65(9):1893-1899.
Li, S., Liu, Y., Liu, G., He, J., Qin, X., Yang, H., Hu, Z., & Lamikanra, O. (2017). Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins. Journal of Agricultural and Food Chemistry, 65(9), 1893-1899. https://doi.org/10.1021/acs.jafc.7b00017
Li S, et al. Effect of the A-Type Linkage On the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins. J Agric Food Chem. 2017 Mar 8;65(9):1893-1899. PubMed PMID: 28195469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins. AU - Li,Shuyi, AU - Liu,Yang, AU - Liu,Gang, AU - He,Jingren, AU - Qin,Xinguang, AU - Yang,Haochen, AU - Hu,Zhongze, AU - Lamikanra,Olusola, Y1 - 2017/02/23/ PY - 2017/2/15/pubmed PY - 2017/6/1/medline PY - 2017/2/15/entrez KW - A-type procyanidin oligomer KW - microbial metabolism KW - pharmacokinetics KW - rats SP - 1893 EP - 1899 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 65 IS - 9 N2 - The bioavailability of A-type procyanidins in vivo has been rarely investigated; as such, this study discusses the effect of A-type linkage and degree of polymerization on the metabolism of procyanidins extracted from litchi pericarp (LPOPC). Sprague-Dawley rats were gavaged with (-)-epicatechin (EC) and LPOPC and sacrificed at different time points after ingestion. A-type linkage procyanidin oligomers inhibited the absorption of EC. Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyanidin trimer (A-3) showed distinct native and metabolite profiles for each rat. Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/28195469/Effect_of_the_A_Type_Linkage_on_the_Pharmacokinetics_and_Intestinal_Metabolism_of_Litchi_Pericarp_Oligomeric_Procyanidins_ L2 - https://doi.org/10.1021/acs.jafc.7b00017 DB - PRIME DP - Unbound Medicine ER -