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Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis.
PLoS One. 2017; 12(2):e0171880.Plos

Abstract

PURPOSE

An autoantibody against aquaporin-4 (AQP4 Ab) is highly specific for neuromyelitis optica spectrum disorder and plays a pathogenic role in this disease. The purpose of this study was to investigate the impact of AQP4 Ab on inner retinal structure, function, and the structure-function relationships in eyes with optic neuritis.

METHODS

Thirty five eyes from 25 cases who had received visual function tests and RTVue optical coherence tomography (OCT) measurement at least six months after the latest episode of optic neuritis were enrolled. Patients with multiple sclerosis were excluded. AQP4 Ab was measured using a cell-based assay. Visual acuity, mean deviation (MD) of the Humphrey visual field SITA standard 30-2 tests, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thicknesses, and other clinical variables were compared between the AQP4 Ab-positive and -negative groups. Parameters associated with visual functions were evaluated by generalized estimating equation (GEE) models.

RESULTS

The AQP4 Ab-positive group (20 eyes from 12 cases) had a higher proportion of bilateral involvement and longer duration of follow-up than the AQP4 Ab-negative group (15 eyes from 13 cases). Linear mixed effect models revealed worse MD and visual acuity in AQP4 Ab-positive eyes than those in AQP4 Ab-negative eyes after adjusting for within-patient inter-eye dependence, whereas there were no differences in RNFL and GCC thickness between the two groups. In seropositive eyes, GEE regression analyses revealed that depending on age and the number of recurrences of ON episodes, OCT parameters correlated strongly with MD and more weakly with visual acuity.

CONCLUSIONS

Reductions in RNFL and GCC thickness were proportional to the visual field defect in eyes with AQP4 Ab but not in eyes without AQP4 Ab. The presence of AQP4 Ab probably plays a critical role in retinal ganglion cell loss in optic neuritis.

Authors+Show Affiliations

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28199381

Citation

Matsumoto, Yoshiko, et al. "Impact of the Anti-aquaporin-4 Autoantibody On Inner Retinal Structure, Function and Structure-function Associations in Japanese Patients With Optic Neuritis." PloS One, vol. 12, no. 2, 2017, pp. e0171880.
Matsumoto Y, Mori S, Ueda K, et al. Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis. PLoS ONE. 2017;12(2):e0171880.
Matsumoto, Y., Mori, S., Ueda, K., Kurimoto, T., Kanamori, A., Yamada, Y., Nakashima, I., & Nakamura, M. (2017). Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis. PloS One, 12(2), e0171880. https://doi.org/10.1371/journal.pone.0171880
Matsumoto Y, et al. Impact of the Anti-aquaporin-4 Autoantibody On Inner Retinal Structure, Function and Structure-function Associations in Japanese Patients With Optic Neuritis. PLoS ONE. 2017;12(2):e0171880. PubMed PMID: 28199381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis. AU - Matsumoto,Yoshiko, AU - Mori,Sotaro, AU - Ueda,Kaori, AU - Kurimoto,Takuji, AU - Kanamori,Akiyasu, AU - Yamada,Yuko, AU - Nakashima,Ichiro, AU - Nakamura,Makoto, Y1 - 2017/02/15/ PY - 2016/07/25/received PY - 2017/01/28/accepted PY - 2017/2/16/entrez PY - 2017/2/16/pubmed PY - 2017/8/29/medline SP - e0171880 EP - e0171880 JF - PloS one JO - PLoS ONE VL - 12 IS - 2 N2 - PURPOSE: An autoantibody against aquaporin-4 (AQP4 Ab) is highly specific for neuromyelitis optica spectrum disorder and plays a pathogenic role in this disease. The purpose of this study was to investigate the impact of AQP4 Ab on inner retinal structure, function, and the structure-function relationships in eyes with optic neuritis. METHODS: Thirty five eyes from 25 cases who had received visual function tests and RTVue optical coherence tomography (OCT) measurement at least six months after the latest episode of optic neuritis were enrolled. Patients with multiple sclerosis were excluded. AQP4 Ab was measured using a cell-based assay. Visual acuity, mean deviation (MD) of the Humphrey visual field SITA standard 30-2 tests, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thicknesses, and other clinical variables were compared between the AQP4 Ab-positive and -negative groups. Parameters associated with visual functions were evaluated by generalized estimating equation (GEE) models. RESULTS: The AQP4 Ab-positive group (20 eyes from 12 cases) had a higher proportion of bilateral involvement and longer duration of follow-up than the AQP4 Ab-negative group (15 eyes from 13 cases). Linear mixed effect models revealed worse MD and visual acuity in AQP4 Ab-positive eyes than those in AQP4 Ab-negative eyes after adjusting for within-patient inter-eye dependence, whereas there were no differences in RNFL and GCC thickness between the two groups. In seropositive eyes, GEE regression analyses revealed that depending on age and the number of recurrences of ON episodes, OCT parameters correlated strongly with MD and more weakly with visual acuity. CONCLUSIONS: Reductions in RNFL and GCC thickness were proportional to the visual field defect in eyes with AQP4 Ab but not in eyes without AQP4 Ab. The presence of AQP4 Ab probably plays a critical role in retinal ganglion cell loss in optic neuritis. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28199381/Impact_of_the_anti_aquaporin_4_autoantibody_on_inner_retinal_structure_function_and_structure_function_associations_in_Japanese_patients_with_optic_neuritis_ L2 - http://dx.plos.org/10.1371/journal.pone.0171880 DB - PRIME DP - Unbound Medicine ER -