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Peripheral Vitamin C Levels in Alzheimer's Disease: A Cross-Sectional Study.
J Nutr Sci Vitaminol (Tokyo) 2016; 62(6):432-436JN

Abstract

We previously reported lower lymphocyte vitamin C levels in individuals with type 2 diabetes mellitus and in individuals with severe Parkinson's disease. Oxidative stress has been proposed to play a key role in the progression of Alzheimer's disease. Thus, the objective of this study was to investigate the association between peripheral levels of vitamin C and the progression of cognitive dysfunction in Alzheimer's disease. Fifty individuals with Alzheimer's disease being treated at Shizuoka General Hospital were consecutively enrolled in this study from December 2009 to March 2015 (76.0±9.7 y of age [mean±SD]; 32 men and 18 women; Mini-Mental State Examination Japanese version (MMSE-J) score range, 8-27). Plasma and lymphocyte vitamin C levels in fasting blood samples were measured. The association between the MMSE-J scores and vitamin C levels was estimated using Spearman's rank correlation coefficient (ρ) and the criteria defined by Swinscow. Spearman's ρ for the relationship between peripheral vitamin C levels and the MMSE-J score was ρ=0.17 for plasma vitamin C and ρ=0.26 for lymphocyte vitamin C. Thus, the associations were relatively weak based on the criteria. In contrast with type 2 diabetes mellitus and Parkinson's disease, lymphocyte vitamin C levels in the peripheral blood may not directly reflect the progression of cognitive dysfunction in Alzheimer's disease. Additional longitudinal studies are needed to evaluate the clinical importance of changes of peripheral vitamin C status in Alzheimer's disease.

Authors+Show Affiliations

Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28202849

Citation

Ide, Kazuki, et al. "Peripheral Vitamin C Levels in Alzheimer's Disease: a Cross-Sectional Study." Journal of Nutritional Science and Vitaminology, vol. 62, no. 6, 2016, pp. 432-436.
Ide K, Yamada H, Kawasaki Y, et al. Peripheral Vitamin C Levels in Alzheimer's Disease: A Cross-Sectional Study. J Nutr Sci Vitaminol. 2016;62(6):432-436.
Ide, K., Yamada, H., Kawasaki, Y., Yamanaka, M., Kawakami, N., Katsuyama, Y., ... Harada, K. (2016). Peripheral Vitamin C Levels in Alzheimer's Disease: A Cross-Sectional Study. Journal of Nutritional Science and Vitaminology, 62(6), pp. 432-436. doi:10.3177/jnsv.62.432.
Ide K, et al. Peripheral Vitamin C Levels in Alzheimer's Disease: a Cross-Sectional Study. J Nutr Sci Vitaminol. 2016;62(6):432-436. PubMed PMID: 28202849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral Vitamin C Levels in Alzheimer's Disease: A Cross-Sectional Study. AU - Ide,Kazuki, AU - Yamada,Hiroshi, AU - Kawasaki,Yohei, AU - Yamanaka,Mie, AU - Kawakami,Nobuko, AU - Katsuyama,Yusuke, AU - Yoshida,Hidefumi, AU - Kim,Kang, AU - Shiosaki,Emi, AU - Sonoda,Akihiro, AU - Umegaki,Keizo, AU - Harada,Kiyoshi, PY - 2017/2/17/entrez PY - 2017/2/17/pubmed PY - 2017/8/16/medline SP - 432 EP - 436 JF - Journal of nutritional science and vitaminology JO - J. Nutr. Sci. Vitaminol. VL - 62 IS - 6 N2 - We previously reported lower lymphocyte vitamin C levels in individuals with type 2 diabetes mellitus and in individuals with severe Parkinson's disease. Oxidative stress has been proposed to play a key role in the progression of Alzheimer's disease. Thus, the objective of this study was to investigate the association between peripheral levels of vitamin C and the progression of cognitive dysfunction in Alzheimer's disease. Fifty individuals with Alzheimer's disease being treated at Shizuoka General Hospital were consecutively enrolled in this study from December 2009 to March 2015 (76.0±9.7 y of age [mean±SD]; 32 men and 18 women; Mini-Mental State Examination Japanese version (MMSE-J) score range, 8-27). Plasma and lymphocyte vitamin C levels in fasting blood samples were measured. The association between the MMSE-J scores and vitamin C levels was estimated using Spearman's rank correlation coefficient (ρ) and the criteria defined by Swinscow. Spearman's ρ for the relationship between peripheral vitamin C levels and the MMSE-J score was ρ=0.17 for plasma vitamin C and ρ=0.26 for lymphocyte vitamin C. Thus, the associations were relatively weak based on the criteria. In contrast with type 2 diabetes mellitus and Parkinson's disease, lymphocyte vitamin C levels in the peripheral blood may not directly reflect the progression of cognitive dysfunction in Alzheimer's disease. Additional longitudinal studies are needed to evaluate the clinical importance of changes of peripheral vitamin C status in Alzheimer's disease. SN - 1881-7742 UR - https://www.unboundmedicine.com/medline/citation/28202849/Peripheral_Vitamin_C_Levels_in_Alzheimer's_Disease:_A_Cross_Sectional_Study_ L2 - https://dx.doi.org/10.3177/jnsv.62.432 DB - PRIME DP - Unbound Medicine ER -