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Assessment of the outcome of ophthalmological screening for uveitis in a cohort of Swedish children with juvenile idiopathic arthritis.
Acta Ophthalmol. 2017 Nov; 95(7):741-747.AO

Abstract

PURPOSE

To describe clinical features, risk factors and complications in a cohort of Swedish children with juvenile idiopathic arthritis (JIA) screened for uveitis between 2002 and 2011.

METHODS

Medical records of 299 children with JIA (93 male, 206 female; median age 5.0 years at diagnosis) were retrospectively scrutinized focusing on subtype of JIA, onset of arthritis/uveitis, presence of antinuclear antibodies (ANA) and ophthalmological status.

RESULTS

Uveitis was found in 32 (11%) children, 78% bilaterally affected. The median age of arthritis onset in children who developed uveitis was 2.5 years (range 1-10) versus 5.0 years (range 1-15) in those who did not. Sex ratio was 3.5:1 (girl:boy). The most prevalent JIA subtype was oligoarthritis (75%). All but one child with uveitis was found to be ANA (+). The median interval between diagnosis of arthritis and uveitis was 12 months. Only one child developed uveitis between the fourth and fifth years after arthritis onset. Ocular complications were recorded in 45.6% (26/57 affected eyes) at last follow-up. On univariate analysis, both young age at arthritis onset and ANA positivity were possible predictors for developing uveitis, but on multivariate analysis, the latter was the most important predictor (HR 16.25, 95%; CI 2.19-120.44; p = 0.006, Cox regression analysis).

CONCLUSION

Almost all of the children developing JIA-associated uveitis did so within 4 years after arthritis onset, a fact that accentuates the importance of early initiation of ophthalmological screening and more frequent regular follow-ups during the first 4 years. The most important predictor for developing uveitis was ANA positivity.

Authors+Show Affiliations

Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, Sweden. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, Sweden. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, Sweden. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28205413

Citation

Papadopoulou, Maria, et al. "Assessment of the Outcome of Ophthalmological Screening for Uveitis in a Cohort of Swedish Children With Juvenile Idiopathic Arthritis." Acta Ophthalmologica, vol. 95, no. 7, 2017, pp. 741-747.
Papadopoulou M, Zetterberg M, Oskarsdottir S, et al. Assessment of the outcome of ophthalmological screening for uveitis in a cohort of Swedish children with juvenile idiopathic arthritis. Acta Ophthalmol. 2017;95(7):741-747.
Papadopoulou, M., Zetterberg, M., Oskarsdottir, S., & Andersson Grönlund, M. (2017). Assessment of the outcome of ophthalmological screening for uveitis in a cohort of Swedish children with juvenile idiopathic arthritis. Acta Ophthalmologica, 95(7), 741-747. https://doi.org/10.1111/aos.13388
Papadopoulou M, et al. Assessment of the Outcome of Ophthalmological Screening for Uveitis in a Cohort of Swedish Children With Juvenile Idiopathic Arthritis. Acta Ophthalmol. 2017;95(7):741-747. PubMed PMID: 28205413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of the outcome of ophthalmological screening for uveitis in a cohort of Swedish children with juvenile idiopathic arthritis. AU - Papadopoulou,Maria, AU - Zetterberg,Madeleine, AU - Oskarsdottir,Solveig, AU - Andersson Grönlund,Marita, Y1 - 2017/02/15/ PY - 2016/04/29/received PY - 2016/12/13/accepted PY - 2017/2/17/pubmed PY - 2018/1/3/medline PY - 2017/2/17/entrez KW - child arthritis KW - complications KW - juvenile idiopathic arthritis KW - risk factor KW - screening KW - uveitis SP - 741 EP - 747 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 95 IS - 7 N2 - PURPOSE: To describe clinical features, risk factors and complications in a cohort of Swedish children with juvenile idiopathic arthritis (JIA) screened for uveitis between 2002 and 2011. METHODS: Medical records of 299 children with JIA (93 male, 206 female; median age 5.0 years at diagnosis) were retrospectively scrutinized focusing on subtype of JIA, onset of arthritis/uveitis, presence of antinuclear antibodies (ANA) and ophthalmological status. RESULTS: Uveitis was found in 32 (11%) children, 78% bilaterally affected. The median age of arthritis onset in children who developed uveitis was 2.5 years (range 1-10) versus 5.0 years (range 1-15) in those who did not. Sex ratio was 3.5:1 (girl:boy). The most prevalent JIA subtype was oligoarthritis (75%). All but one child with uveitis was found to be ANA (+). The median interval between diagnosis of arthritis and uveitis was 12 months. Only one child developed uveitis between the fourth and fifth years after arthritis onset. Ocular complications were recorded in 45.6% (26/57 affected eyes) at last follow-up. On univariate analysis, both young age at arthritis onset and ANA positivity were possible predictors for developing uveitis, but on multivariate analysis, the latter was the most important predictor (HR 16.25, 95%; CI 2.19-120.44; p = 0.006, Cox regression analysis). CONCLUSION: Almost all of the children developing JIA-associated uveitis did so within 4 years after arthritis onset, a fact that accentuates the importance of early initiation of ophthalmological screening and more frequent regular follow-ups during the first 4 years. The most important predictor for developing uveitis was ANA positivity. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/28205413/Assessment_of_the_outcome_of_ophthalmological_screening_for_uveitis_in_a_cohort_of_Swedish_children_with_juvenile_idiopathic_arthritis_ L2 - https://doi.org/10.1111/aos.13388 DB - PRIME DP - Unbound Medicine ER -