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Food Protein-Induced Enterocolitis Syndrome.

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Chronic FPIES manifests with intermittent emesis, watery diarrhea, and poor growth progressing to dehydration and hypovolemic shock over a period of days to weeks. Chronic FPIES has been only reported in infants aged less than 3 months fed with cow milk (CM) or soy formula. The most common triggers are CM, soy, rice, and oat. Diagnosis of FPIES relies on recognition of a pattern of clinical symptoms and may be missed owing to the absence of typical allergic symptoms (eg, urticaria, wheezing) and delayed onset in relation to food ingestion. Physician-supervised food challenge is recommended if diagnosis or the trigger food is not clear and to evaluate for resolution. Testing for food-specific IgE is usually negative, although a subset of patients, usually with CM-induced FPIES may develop sensitization to foods. Such atypical FPIES tends to have a more prolonged course. Despite the potential severity of the reactions, no fatalities have been reported, and FPIES has a favorable prognosis. In most cases, FPIES resolves by age 3-5 years, although persistence of CM-induced FPIES and soy FPIES into adulthood has been reported. The first international consensus guidelines on diagnosis and management of FPIES were published in 2017. Given that the pathophysiology of FPIES is poorly understood, there are no diagnostic biomarkers and no therapies to accelerate resolution. These unmet needs warrant future investigations to improve the care of patients with FPIES.

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  • Authors+Show Affiliations

    ,

    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    ,

    Department of Pediatrics, Gastroenterology and Nutrition, Children's Hospital, University of Warmia and Masuria, Olsztyn, Poland.

    Unidade de Alergia e Imunologia do Instituto da Criança, HC Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

    Source

    MeSH

    Child, Preschool
    Dietary Proteins
    Enterocolitis
    Food Hypersensitivity
    Humans
    Immunity, Cellular
    Immunologic Tests
    Infant
    Prognosis
    Risk Factors
    Severity of Illness Index
    Syndrome
    Time Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28211341

    Citation

    Nowak-Węgrzyn, A, et al. "Food Protein-Induced Enterocolitis Syndrome." Journal of Investigational Allergology & Clinical Immunology, vol. 27, no. 1, 2017, pp. 1-18.
    Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A. Food Protein-Induced Enterocolitis Syndrome. J Investig Allergol Clin Immunol. 2017;27(1):1-18.
    Nowak-Węgrzyn, A., Jarocka-Cyrta, E., & Moschione Castro, A. (2017). Food Protein-Induced Enterocolitis Syndrome. Journal of Investigational Allergology & Clinical Immunology, 27(1), pp. 1-18. doi:10.18176/jiaci.0135.
    Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A. Food Protein-Induced Enterocolitis Syndrome. J Investig Allergol Clin Immunol. 2017;27(1):1-18. PubMed PMID: 28211341.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Food Protein-Induced Enterocolitis Syndrome. AU - Nowak-Węgrzyn,A, AU - Jarocka-Cyrta,E, AU - Moschione Castro,Apb, PY - 2017/2/18/entrez PY - 2017/2/18/pubmed PY - 2017/6/7/medline KW - Cow milk allergy KW - FPIES KW - Food allergy KW - Food protein-induced enterocolitis syndrome KW - Non–IgE-mediated food allergy SP - 1 EP - 18 JF - Journal of investigational allergology & clinical immunology JO - J Investig Allergol Clin Immunol VL - 27 IS - 1 N2 - Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Chronic FPIES manifests with intermittent emesis, watery diarrhea, and poor growth progressing to dehydration and hypovolemic shock over a period of days to weeks. Chronic FPIES has been only reported in infants aged less than 3 months fed with cow milk (CM) or soy formula. The most common triggers are CM, soy, rice, and oat. Diagnosis of FPIES relies on recognition of a pattern of clinical symptoms and may be missed owing to the absence of typical allergic symptoms (eg, urticaria, wheezing) and delayed onset in relation to food ingestion. Physician-supervised food challenge is recommended if diagnosis or the trigger food is not clear and to evaluate for resolution. Testing for food-specific IgE is usually negative, although a subset of patients, usually with CM-induced FPIES may develop sensitization to foods. Such atypical FPIES tends to have a more prolonged course. Despite the potential severity of the reactions, no fatalities have been reported, and FPIES has a favorable prognosis. In most cases, FPIES resolves by age 3-5 years, although persistence of CM-induced FPIES and soy FPIES into adulthood has been reported. The first international consensus guidelines on diagnosis and management of FPIES were published in 2017. Given that the pathophysiology of FPIES is poorly understood, there are no diagnostic biomarkers and no therapies to accelerate resolution. These unmet needs warrant future investigations to improve the care of patients with FPIES. SN - 1018-9068 UR - https://www.unboundmedicine.com/medline/citation/28211341/Food_Protein_Induced_Enterocolitis_Syndrome_ L2 - http://www.jiaci.org/summary/vol27-issue1-num1451 DB - PRIME DP - Unbound Medicine ER -