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The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH.
Mar Drugs 2017; 15(2)MD

Abstract

Edible seaweeds have been consumed by Asian coastal communities since ancient times. Fucus vesiculosus and Ascophyllum nodosum extracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM). This model was obtained by the administration of a high-fat diet. Our results demonstrate that these algae only delayed and reduced the peak of blood glucose (p < 0.05) in mice fed with normal diet, without changing the area under the blood glucose curve (AUC). In the model of NASH, the phytocomplex was able to reduce both the postprandial glycaemic peak, and the AUC. The administration of the extract in a diet particularly rich in fat is associated with a delay in carbohydrate digestion, but also with a decrease in its assimilation. In conclusion, our results indicate that this algal extract may be useful in the control of carbohydrate digestion and absorption. This effect may be therapeutically exploited to prevent the transition of NASH to T2DM.

Authors+Show Affiliations

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. daniela.gabbia@gmail.com.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. stefano.dallacqua@unipd.it.Department of Chemical Sciences, University of Padova, 35131 Padova, Italy. iolemaria.digangi@unipd.it.Department of Chemical Sciences, University of Padova, 35131 Padova, Italy. sara.bogialli@unipd.it.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. valekap@gmail.com.Department of Medicine, General Pathology and Cytopathology Unit, University of Padova, 35128 Padova, Italy. aoichan@libero.it.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. ilaria.marsilio@gmail.com.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. nicolapaccagnella89@gmail.com.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. maria.carrara@unipd.it.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. ceci.giron@gmail.com.Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. sara.demartin@unipd.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28212301

Citation

Gabbia, Daniela, et al. "The Phytocomplex From Fucus Vesiculosus and Ascophyllum Nodosum Controls Postprandial Plasma Glucose Levels: an in Vitro and in Vivo Study in a Mouse Model of NASH." Marine Drugs, vol. 15, no. 2, 2017.
Gabbia D, Dall'Acqua S, Di Gangi IM, et al. The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Mar Drugs. 2017;15(2).
Gabbia, D., Dall'Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., ... De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Marine Drugs, 15(2), doi:10.3390/md15020041.
Gabbia D, et al. The Phytocomplex From Fucus Vesiculosus and Ascophyllum Nodosum Controls Postprandial Plasma Glucose Levels: an in Vitro and in Vivo Study in a Mouse Model of NASH. Mar Drugs. 2017 Feb 15;15(2) PubMed PMID: 28212301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. AU - Gabbia,Daniela, AU - Dall'Acqua,Stefano, AU - Di Gangi,Iole Maria, AU - Bogialli,Sara, AU - Caputi,Valentina, AU - Albertoni,Laura, AU - Marsilio,Ilaria, AU - Paccagnella,Nicola, AU - Carrara,Maria, AU - Giron,Maria Cecilia, AU - De Martin,Sara, Y1 - 2017/02/15/ PY - 2016/10/21/received PY - 2017/02/08/revised PY - 2017/02/09/accepted PY - 2017/2/18/entrez PY - 2017/2/18/pubmed PY - 2017/7/8/medline KW - Ascophyllum nodosum KW - Fucus vesiculosus KW - nonalcoholic steatohepatitis KW - postprandial blood glucose level JF - Marine drugs JO - Mar Drugs VL - 15 IS - 2 N2 - Edible seaweeds have been consumed by Asian coastal communities since ancient times. Fucus vesiculosus and Ascophyllum nodosum extracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM). This model was obtained by the administration of a high-fat diet. Our results demonstrate that these algae only delayed and reduced the peak of blood glucose (p < 0.05) in mice fed with normal diet, without changing the area under the blood glucose curve (AUC). In the model of NASH, the phytocomplex was able to reduce both the postprandial glycaemic peak, and the AUC. The administration of the extract in a diet particularly rich in fat is associated with a delay in carbohydrate digestion, but also with a decrease in its assimilation. In conclusion, our results indicate that this algal extract may be useful in the control of carbohydrate digestion and absorption. This effect may be therapeutically exploited to prevent the transition of NASH to T2DM. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/28212301/The_Phytocomplex_from_Fucus_vesiculosus_and_Ascophyllum_nodosum_Controls_Postprandial_Plasma_Glucose_Levels:_An_In_Vitro_and_In_Vivo_Study_in_a_Mouse_Model_of_NASH_ L2 - http://www.mdpi.com/resolver?pii=md15020041 DB - PRIME DP - Unbound Medicine ER -