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Early calibration of the HPA axis by maternal psychopathology.
Psychoneuroendocrinology. 2017 04; 78:177-184.P

Abstract

Given the central role of stress-responsive neurophysiology in mental and physical health, it is important to understand how particular patterns of stress responsivity may become entrained by the early caregiving environment. In this study we investigated links between maternal depression and anxiety symptom profiles and within-infant development of hypothalamic-pituitary-adrenal (HPA) axis responses from 6 to 18 months of life. Associations with infant cognitive and social-emotional development were also tested to gauge the adjustment implications of HPA response trajectories. Mothers from a low-income community sample reported their symptoms at 3, 6, 12, and 18 months postnatal, and infants engaged in interpersonal stress tasks at 6, 12, and 18 months. Four saliva samples were taken at each time to assess cortisol responses, and a developmental screener at 18 months provided an index of infant adjustment. Multilevel modeling results revealed an association between maternal symptoms and infant HPA axis sensitization-i.e., a higher cortisol reactivity slope that increased over time. In particular, early (3-month) depression symptoms among mothers who had crossed a diagnostic threshold for major depressive disorder predicted this pattern of response, which in turn related to poorer infant developmental outcomes. Results are considered in terms of adaptive calibration of stress response systems, which may come at a cost to individual psychosocial functioning.

Authors+Show Affiliations

University of Oregon, Dept. of Psychology, 1227 University of Oregon, Eugene, OR 97403, United States; University of Illinois, Dept. of Psychology, 603 E. Daniel St., Champaign, IL 61820, United States. Electronic address: hlaurent@illinois.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28212519

Citation

Laurent, Heidemarie. "Early Calibration of the HPA Axis By Maternal Psychopathology." Psychoneuroendocrinology, vol. 78, 2017, pp. 177-184.
Laurent H. Early calibration of the HPA axis by maternal psychopathology. Psychoneuroendocrinology. 2017;78:177-184.
Laurent, H. (2017). Early calibration of the HPA axis by maternal psychopathology. Psychoneuroendocrinology, 78, 177-184. https://doi.org/10.1016/j.psyneuen.2017.01.034
Laurent H. Early Calibration of the HPA Axis By Maternal Psychopathology. Psychoneuroendocrinology. 2017;78:177-184. PubMed PMID: 28212519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early calibration of the HPA axis by maternal psychopathology. A1 - Laurent,Heidemarie, Y1 - 2017/02/01/ PY - 2016/11/16/received PY - 2016/12/29/revised PY - 2017/01/30/accepted PY - 2017/2/18/pubmed PY - 2017/12/8/medline PY - 2017/2/18/entrez KW - Anxiety KW - Cortisol KW - Depression KW - HPA axis KW - Infant KW - Mother SP - 177 EP - 184 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 78 N2 - Given the central role of stress-responsive neurophysiology in mental and physical health, it is important to understand how particular patterns of stress responsivity may become entrained by the early caregiving environment. In this study we investigated links between maternal depression and anxiety symptom profiles and within-infant development of hypothalamic-pituitary-adrenal (HPA) axis responses from 6 to 18 months of life. Associations with infant cognitive and social-emotional development were also tested to gauge the adjustment implications of HPA response trajectories. Mothers from a low-income community sample reported their symptoms at 3, 6, 12, and 18 months postnatal, and infants engaged in interpersonal stress tasks at 6, 12, and 18 months. Four saliva samples were taken at each time to assess cortisol responses, and a developmental screener at 18 months provided an index of infant adjustment. Multilevel modeling results revealed an association between maternal symptoms and infant HPA axis sensitization-i.e., a higher cortisol reactivity slope that increased over time. In particular, early (3-month) depression symptoms among mothers who had crossed a diagnostic threshold for major depressive disorder predicted this pattern of response, which in turn related to poorer infant developmental outcomes. Results are considered in terms of adaptive calibration of stress response systems, which may come at a cost to individual psychosocial functioning. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/28212519/Early_calibration_of_the_HPA_axis_by_maternal_psychopathology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(16)30922-2 DB - PRIME DP - Unbound Medicine ER -