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The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease.
Adv Parasitol. 2017; 96:259-369.AP

Abstract

The echinococcoses are chronic, parasitic diseases that are acquired after ingestion of infective taeniid tapeworm eggs from certain species of the genus Echinococcus. Cystic echinococcosis (CE) occurs worldwide, whereas, alveolar echinococcosis (AE) is restricted to the northern hemisphere, and neotropical echinococcosis (NE) has only been identified in Central and South America. Clinical manifestations and disease courses vary profoundly for the different species of Echinococcus. CE presents as small to large cysts, and has commonly been referred to as 'hydatid disease', or 'hydatidosis'. A structured stage-specific approach to CE management, based on the World Health Organization (WHO) ultrasound classification of liver cysts, is now recommended. Management options include percutaneous sterilization techniques, surgery, drug treatment, a 'watch-and-wait' approach or combinations thereof. In contrast, clinical manifestations associated with AE resemble those of a 'malignant', silently-progressing liver disease, with local tissue infiltration and metastases. Structured care is important for AE management and includes WHO staging, drug therapy and long-term follow-up for at least a decade. NE presents as polycystic or unicystic disease. Clinical characteristics resemble those of AE, and management needs to be structured accordingly. However, to date, only a few hundreds of cases have been reported in the literature. The echinococcoses are often expensive and complicated to treat, and prospective clinical studies are needed to better inform case management decisions.

Authors+Show Affiliations

University Hospital of Ulm, Ulm, Germany.Estrada da Luz, Lisboa, Portugal.Hacettepe University, Ankara, Turkey.University Hospital of Zurich, Zürich, Switzerland.National Institute of Infectious Diseases, Buenos Aires, Argentina.Texas A&M University, College Station, TX, United States.Université de Franche-Comté, Besançon, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28212790

Citation

Kern, P, et al. "The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease." Advances in Parasitology, vol. 96, 2017, pp. 259-369.
Kern P, Menezes da Silva A, Akhan O, et al. The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease. Adv Parasitol. 2017;96:259-369.
Kern, P., Menezes da Silva, A., Akhan, O., Müllhaupt, B., Vizcaychipi, K. A., Budke, C., & Vuitton, D. A. (2017). The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease. Advances in Parasitology, 96, 259-369. https://doi.org/10.1016/bs.apar.2016.09.006
Kern P, et al. The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease. Adv Parasitol. 2017;96:259-369. PubMed PMID: 28212790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease. AU - Kern,P, AU - Menezes da Silva,A, AU - Akhan,O, AU - Müllhaupt,B, AU - Vizcaychipi,K A, AU - Budke,C, AU - Vuitton,D A, Y1 - 2017/02/08/ PY - 2017/2/19/entrez PY - 2017/2/19/pubmed PY - 2017/8/2/medline KW - Alveolar echinococcosis KW - Benzimidazoles KW - Burden of echinococcoses KW - Cystic echinococcosis KW - Imaging procedures KW - Liver transplantation KW - Metacestode diseases KW - Neotropical echinococcoses KW - Percutaneous sterilization techniques KW - Surgery KW - Watch-and-wait SP - 259 EP - 369 JF - Advances in parasitology JO - Adv. Parasitol. VL - 96 N2 - The echinococcoses are chronic, parasitic diseases that are acquired after ingestion of infective taeniid tapeworm eggs from certain species of the genus Echinococcus. Cystic echinococcosis (CE) occurs worldwide, whereas, alveolar echinococcosis (AE) is restricted to the northern hemisphere, and neotropical echinococcosis (NE) has only been identified in Central and South America. Clinical manifestations and disease courses vary profoundly for the different species of Echinococcus. CE presents as small to large cysts, and has commonly been referred to as 'hydatid disease', or 'hydatidosis'. A structured stage-specific approach to CE management, based on the World Health Organization (WHO) ultrasound classification of liver cysts, is now recommended. Management options include percutaneous sterilization techniques, surgery, drug treatment, a 'watch-and-wait' approach or combinations thereof. In contrast, clinical manifestations associated with AE resemble those of a 'malignant', silently-progressing liver disease, with local tissue infiltration and metastases. Structured care is important for AE management and includes WHO staging, drug therapy and long-term follow-up for at least a decade. NE presents as polycystic or unicystic disease. Clinical characteristics resemble those of AE, and management needs to be structured accordingly. However, to date, only a few hundreds of cases have been reported in the literature. The echinococcoses are often expensive and complicated to treat, and prospective clinical studies are needed to better inform case management decisions. SN - 2163-6079 UR - https://www.unboundmedicine.com/medline/citation/28212790/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0065-308X(16)30089-6 DB - PRIME DP - Unbound Medicine ER -