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Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder.
Brain Topogr 2017; 30(5):656-672BT

Abstract

Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has been repeatedly shown to improve working memory (WM). Since patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in WM, the modulation of prefrontal activity with tDCS in ADHD patients may increase their WM performance as well as improve the activation and connectivity of the WM network. In the present study, this hypothesis was tested using a double-blind sham-controlled experimental design. After randomization, sixteen adolescents with ADHD underwent either anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC, 1 mA, 20 min) or sham stimulation with simultaneous fMRI during n-back WM task. Both in one-back and two-back conditions, tDCS led to a greater activation (compared with sham stimulation) of the left DLPFC (under the electrode), left premotor cortex, left supplementary motor cortex, and precuneus. The effects of tDCS were long-lasting and influenced resting state functional connectivity even 20 min after the stimulation, with patterns of strengthened DLPFC connectivity after tDCS outlining the WM network. In summary, anodal tDCS caused increased neuronal activation and connectivity, not only in the brain area under the stimulating electrode (i.e. left DLPFC) but also in other, more remote brain regions. Because of moderate behavioral effects of tDCS, the significance of this technique for ADHD treatment has to be investigated in further studies.

Authors+Show Affiliations

Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, 35096, Germany.Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, 35096, Germany.Institute of Medical Psychology and Medical Sociology, Christian-Albrechts-University, Preuβerstraβe 1-9, Kiel, 24105, Germany.Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, 35096, Germany.Institute of Medical Psychology and Medical Sociology, Christian-Albrechts-University, Preuβerstraβe 1-9, Kiel, 24105, Germany. siniatchkin@med-psych.uni-kiel.de.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28213645

Citation

Sotnikova, Anna, et al. "Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder." Brain Topography, vol. 30, no. 5, 2017, pp. 656-672.
Sotnikova A, Soff C, Tagliazucchi E, et al. Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder. Brain Topogr. 2017;30(5):656-672.
Sotnikova, A., Soff, C., Tagliazucchi, E., Becker, K., & Siniatchkin, M. (2017). Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder. Brain Topography, 30(5), pp. 656-672. doi:10.1007/s10548-017-0552-4.
Sotnikova A, et al. Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder. Brain Topogr. 2017;30(5):656-672. PubMed PMID: 28213645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder. AU - Sotnikova,Anna, AU - Soff,Cornelia, AU - Tagliazucchi,Enzo, AU - Becker,Katja, AU - Siniatchkin,Michael, Y1 - 2017/02/17/ PY - 2015/11/26/received PY - 2017/01/27/accepted PY - 2017/2/19/pubmed PY - 2018/7/28/medline PY - 2017/2/19/entrez KW - ADHD KW - Transcranial direct current stimulation KW - Working memory KW - fMRI SP - 656 EP - 672 JF - Brain topography JO - Brain Topogr VL - 30 IS - 5 N2 - Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has been repeatedly shown to improve working memory (WM). Since patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in WM, the modulation of prefrontal activity with tDCS in ADHD patients may increase their WM performance as well as improve the activation and connectivity of the WM network. In the present study, this hypothesis was tested using a double-blind sham-controlled experimental design. After randomization, sixteen adolescents with ADHD underwent either anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC, 1 mA, 20 min) or sham stimulation with simultaneous fMRI during n-back WM task. Both in one-back and two-back conditions, tDCS led to a greater activation (compared with sham stimulation) of the left DLPFC (under the electrode), left premotor cortex, left supplementary motor cortex, and precuneus. The effects of tDCS were long-lasting and influenced resting state functional connectivity even 20 min after the stimulation, with patterns of strengthened DLPFC connectivity after tDCS outlining the WM network. In summary, anodal tDCS caused increased neuronal activation and connectivity, not only in the brain area under the stimulating electrode (i.e. left DLPFC) but also in other, more remote brain regions. Because of moderate behavioral effects of tDCS, the significance of this technique for ADHD treatment has to be investigated in further studies. SN - 1573-6792 UR - https://www.unboundmedicine.com/medline/citation/28213645/Transcranial_Direct_Current_Stimulation_Modulates_Neuronal_Networks_in_Attention_Deficit_Hyperactivity_Disorder_ L2 - https://doi.org/10.1007/s10548-017-0552-4 DB - PRIME DP - Unbound Medicine ER -