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Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health.
Curr Protein Pept Sci 2017; 18(8):795-808CP

Abstract

There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which gives rise to the view that function between the microbiota and protein can proceed in both directions. In response to the alterations in dietary protein components, there are significant changes in the microbial metabolites including short chain fatty acids (SCFAs), ammonia, amines, gases such as hydrogen, sulfide and methane which are cytotoxins, genotoxins and carcinogens associated with development of colon cancer and inflammatory bowel diseases. A suitable ratio between protein and carbohydrate or even a low protein diet is recommended based on the evidence that excessive protein intake adversely affects health. Supplying high and undigested proteins will encourage pathogens and protein-fermenting bacteria to increase the risk of diseases. These changes of microbiota can affect the gut barrier and the immune system by regulating gene expression in relevant signaling pathways and by regulating the secretion of metabolites. The objective of this review is to assess the impact of dietary proteins on microbiota composition and activity in the gastrointestinal tract. Attention should be given to the dietary strategies with judicious selection of source and supplementation of dietary protein to benefit gut health.

Authors+Show Affiliations

State Key Lab of Animal Nutrition, China Agricultural University, No 2. Yuanmingyuan West Road, Beijing, 100193, China.Department of Animal Science, Texas A&M University, College Station, Texas, TX 77843, United States.State Key Lab of Animal Nutrition, China Agricultural University, No 2. Yuanmingyuan West Road, Beijing, 100193, China.State Key Lab of Animal Nutrition, China Agricultural University, Beijing, 100193, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28215168

Citation

Ma, Ning, et al. "Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health." Current Protein & Peptide Science, vol. 18, no. 8, 2017, pp. 795-808.
Ma N, Tian Y, Wu Y, et al. Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. Curr Protein Pept Sci. 2017;18(8):795-808.
Ma, N., Tian, Y., Wu, Y., & Ma, X. (2017). Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. Current Protein & Peptide Science, 18(8), pp. 795-808. doi:10.2174/1389203718666170216153505.
Ma N, et al. Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. Curr Protein Pept Sci. 2017;18(8):795-808. PubMed PMID: 28215168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. AU - Ma,Ning, AU - Tian,Yanan, AU - Wu,Yi, AU - Ma,Xi, PY - 2016/12/03/received PY - 2017/02/09/revised PY - 2017/02/11/accepted PY - 2017/2/22/pubmed PY - 2017/11/7/medline PY - 2017/2/21/entrez KW - Dietary protein KW - amino acid balance KW - digestibility KW - gut barrier KW - intestinal microbiota KW - metabolites SP - 795 EP - 808 JF - Current protein & peptide science JO - Curr. Protein Pept. Sci. VL - 18 IS - 8 N2 - There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which gives rise to the view that function between the microbiota and protein can proceed in both directions. In response to the alterations in dietary protein components, there are significant changes in the microbial metabolites including short chain fatty acids (SCFAs), ammonia, amines, gases such as hydrogen, sulfide and methane which are cytotoxins, genotoxins and carcinogens associated with development of colon cancer and inflammatory bowel diseases. A suitable ratio between protein and carbohydrate or even a low protein diet is recommended based on the evidence that excessive protein intake adversely affects health. Supplying high and undigested proteins will encourage pathogens and protein-fermenting bacteria to increase the risk of diseases. These changes of microbiota can affect the gut barrier and the immune system by regulating gene expression in relevant signaling pathways and by regulating the secretion of metabolites. The objective of this review is to assess the impact of dietary proteins on microbiota composition and activity in the gastrointestinal tract. Attention should be given to the dietary strategies with judicious selection of source and supplementation of dietary protein to benefit gut health. SN - 1875-5550 UR - https://www.unboundmedicine.com/medline/citation/28215168/Contributions_of_the_Interaction_Between_Dietary_Protein_and_Gut_Microbiota_to_Intestinal_Health_ L2 - http://www.eurekaselect.com/150179/article DB - PRIME DP - Unbound Medicine ER -