Tags

Type your tag names separated by a space and hit enter

Significance of uterine corpus tumor invasion in early-stage cervical cancer.
Eur J Surg Oncol. 2017 Apr; 43(4):725-734.EJ

Abstract

OBJECTIVE

To examine characteristics and survival outcomes of women with surgically-treated cervical cancer exhibiting uterine corpus tumor invasion.

METHODS

We utilized The Surveillance, Epidemiology, and End Results Program to identify cervical cancer patients who underwent hysterectomy between 1973 and 2003. Logistic regression models were used to identify risk factors for uterine corpus tumor invasion on multivariable analysis. Association of uterine corpus tumor invasion and cause-specific survival (CSS) from cervical cancer was examined with Cox proportional hazard regression models on multivariable analysis.

RESULTS

We identified 837 (4.9%) cases of uterine corpus invasion and 16,237 (95.1%) cases of non-invasion. Median follow-up time was 14.0 years. There were 1642 deaths due to cervical cancer. Uterine corpus invasion was independently associated with older age, non-squamous histology, high-grade tumors, large tumor size, and nodal metastasis on multivariable analysis (all, P < 0.001). On univariable analysis, uterine corpus tumor invasion was significantly associated with decreased CSS compared to the non-invasion (5-year rates, 79.0% versus 94.5%, P < 0.001). After controlling for other significant prognostic factors, uterine corpus tumor invasion remained an independent prognostic factor for decreased CSS (adjusted-hazard ratio 1.45, 95% confidence interval 1.21-1.74). Among stage T1b cases (n = 6730), uterine corpus tumor invasion remained an independent prognostic factor for decreased CSS (adjusted-hazard ratio 1.95, 95%CI 1.47-2.60). Uterine corpus tumor invasion was significantly associated with decreased CSS in stage T1b1 disease (74.5% versus 90.7%, P < 0.001) and in stage T1b2 disease (67.0% versus 79.5%, P = 0.01).

CONCLUSION

Uterine corpus tumor invasion is an independent prognostic factor for decreased survival of women with early-stage cervical cancer.

Authors+Show Affiliations

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address: koji.matsuo@med.usc.edu.Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.Department of Obstetrics and Gynecology, University of Colorado, Denver, CO, USA.Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28215507

Citation

Matsuo, K, et al. "Significance of Uterine Corpus Tumor Invasion in Early-stage Cervical Cancer." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 43, no. 4, 2017, pp. 725-734.
Matsuo K, Machida H, Blake EA, et al. Significance of uterine corpus tumor invasion in early-stage cervical cancer. Eur J Surg Oncol. 2017;43(4):725-734.
Matsuo, K., Machida, H., Blake, E. A., Takiuchi, T., Mikami, M., & Roman, L. D. (2017). Significance of uterine corpus tumor invasion in early-stage cervical cancer. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 43(4), 725-734. https://doi.org/10.1016/j.ejso.2017.01.017
Matsuo K, et al. Significance of Uterine Corpus Tumor Invasion in Early-stage Cervical Cancer. Eur J Surg Oncol. 2017;43(4):725-734. PubMed PMID: 28215507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of uterine corpus tumor invasion in early-stage cervical cancer. AU - Matsuo,K, AU - Machida,H, AU - Blake,E A, AU - Takiuchi,T, AU - Mikami,M, AU - Roman,L D, Y1 - 2017/02/03/ PY - 2016/11/07/received PY - 2017/01/09/revised PY - 2017/01/24/accepted PY - 2017/2/22/pubmed PY - 2017/4/18/medline PY - 2017/2/21/entrez KW - Cervical cancer KW - Lymph node metastasis KW - Survival outcome KW - Uterine corpus SP - 725 EP - 734 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 43 IS - 4 N2 - OBJECTIVE: To examine characteristics and survival outcomes of women with surgically-treated cervical cancer exhibiting uterine corpus tumor invasion. METHODS: We utilized The Surveillance, Epidemiology, and End Results Program to identify cervical cancer patients who underwent hysterectomy between 1973 and 2003. Logistic regression models were used to identify risk factors for uterine corpus tumor invasion on multivariable analysis. Association of uterine corpus tumor invasion and cause-specific survival (CSS) from cervical cancer was examined with Cox proportional hazard regression models on multivariable analysis. RESULTS: We identified 837 (4.9%) cases of uterine corpus invasion and 16,237 (95.1%) cases of non-invasion. Median follow-up time was 14.0 years. There were 1642 deaths due to cervical cancer. Uterine corpus invasion was independently associated with older age, non-squamous histology, high-grade tumors, large tumor size, and nodal metastasis on multivariable analysis (all, P < 0.001). On univariable analysis, uterine corpus tumor invasion was significantly associated with decreased CSS compared to the non-invasion (5-year rates, 79.0% versus 94.5%, P < 0.001). After controlling for other significant prognostic factors, uterine corpus tumor invasion remained an independent prognostic factor for decreased CSS (adjusted-hazard ratio 1.45, 95% confidence interval 1.21-1.74). Among stage T1b cases (n = 6730), uterine corpus tumor invasion remained an independent prognostic factor for decreased CSS (adjusted-hazard ratio 1.95, 95%CI 1.47-2.60). Uterine corpus tumor invasion was significantly associated with decreased CSS in stage T1b1 disease (74.5% versus 90.7%, P < 0.001) and in stage T1b2 disease (67.0% versus 79.5%, P = 0.01). CONCLUSION: Uterine corpus tumor invasion is an independent prognostic factor for decreased survival of women with early-stage cervical cancer. SN - 1532-2157 UR - https://www.unboundmedicine.com/medline/citation/28215507/Significance_of_uterine_corpus_tumor_invasion_in_early_stage_cervical_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(17)30112-9 DB - PRIME DP - Unbound Medicine ER -