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Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.

Abstract

AIM

To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).

METHODS

Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI).

RESULTS

We identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI >30 kg/m2 (39% vs 23% P = 0.01) and CD (40% vs 26%, P = 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/m2 and AA race are associated with vitamin D deficiency.

CONCLUSION

BMI > 30 kg/m2 and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency.

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  • Authors+Show Affiliations

    ,

    Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.

    ,

    Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.

    ,

    Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.

    ,

    Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.

    Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.

    Source

    World journal of gastroenterology 23:4 2017 Jan 28 pg 638-645

    MeSH

    Adult
    African Americans
    Aged
    Biopsy
    Body Mass Index
    Case-Control Studies
    Colitis, Ulcerative
    Crohn Disease
    Female
    Humans
    Male
    Middle Aged
    Mississippi
    Odds Ratio
    Pilot Projects
    Regression Analysis
    Retrospective Studies
    Seasons
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28216970

    Citation

    Pallav, Kumar, et al. "Predictors of Vitamin D Deficiency in Inflammatory Bowel Disease and Health: a Mississippi Perspective." World Journal of Gastroenterology, vol. 23, no. 4, 2017, pp. 638-645.
    Pallav K, Riche D, May WL, et al. Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective. World J Gastroenterol. 2017;23(4):638-645.
    Pallav, K., Riche, D., May, W. L., Sanchez, P., & Gupta, N. K. (2017). Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective. World Journal of Gastroenterology, 23(4), pp. 638-645. doi:10.3748/wjg.v23.i4.638.
    Pallav K, et al. Predictors of Vitamin D Deficiency in Inflammatory Bowel Disease and Health: a Mississippi Perspective. World J Gastroenterol. 2017 Jan 28;23(4):638-645. PubMed PMID: 28216970.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective. AU - Pallav,Kumar, AU - Riche,Daniel, AU - May,Warren L, AU - Sanchez,Patrick, AU - Gupta,Nitin K, PY - 2016/09/04/received PY - 2016/12/05/revised PY - 2016/12/21/accepted PY - 2017/2/21/entrez PY - 2017/2/22/pubmed PY - 2017/8/15/medline KW - African American KW - Body mass index KW - Crohn’s disease KW - Inflammatory bowel disease KW - Ulcerative colitis KW - Vitamin D deficiency SP - 638 EP - 645 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 23 IS - 4 N2 - AIM: To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD). METHODS: Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI). RESULTS: We identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI >30 kg/m2 (39% vs 23% P = 0.01) and CD (40% vs 26%, P = 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/m2 and AA race are associated with vitamin D deficiency. CONCLUSION: BMI > 30 kg/m2 and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/28216970/Predictors_of_vitamin_D_deficiency_in_inflammatory_bowel_disease_and_health:_A_Mississippi_perspective_ L2 - http://www.wjgnet.com/1007-9327/full/v23/i4/638.htm DB - PRIME DP - Unbound Medicine ER -